NUDC1_HUMAN - dbPTM
NUDC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NUDC1_HUMAN
UniProt AC Q96RS6
Protein Name NudC domain-containing protein 1
Gene Name NUDCD1 {ECO:0000312|HGNC:HGNC:24306}
Organism Homo sapiens (Human).
Sequence Length 583
Subcellular Localization Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm. Nucleus.
Protein Description
Protein Sequence MEVAANCSLRVKRPLLDPRFEGYKLSLEPLPCYQLELDAAVAEVKLRDDQYTLEHMHAFGMYNYLHCDSWYQDSVYYIDTLGRIMNLTVMLDTALGKPREVFRLPTDLTACDNRLCASIHFSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEELGDPFIIIHSISLLNAEEHSIATLLLRIEKEELDMKGSGFYVSLEWVTISKKNQDNKKYEIIKRDILRGKSVPHYAAIEPDGNGLMIVSYKSLTFVQAGQDLEENMDEDISEKIKEPLYYWQQTEDDLTVTIRLPEDSTKEDIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESSTWIIKESNSLEISLIKKNEGLTWPELVIGDKQGELIRDSAQCAAIAERLMHLTSEELNPNPDKEKPPCNAQELEECDIFFEESSSLCRFDGNTLKTTHVVNLGSNQYLFSVIVDPKEMPCFCLRHDVDALLWQPHSSKQDDMWEHIATFNALGYVQASKRDKKFFACAPNYSYAALCECLRRVFIYRQPAPMSTVLYNRKEGRQVGQVAKQQVASLETNDPILGFQATNERLFVLTTKNLFLIKVNTEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEVAANCS
-------CCEECCCE		9.37-
1Sulfoxidation-------MEVAANCS
-------CCEECCCE		9.3728465586
3 (in isoform 2)Phosphorylation-6.1826503514
8PhosphorylationMEVAANCSLRVKRPL
CCEECCCEEEECCCC		21.0130108239
8 (in isoform 2)Phosphorylation-21.0126503514
68 (in isoform 2)Ubiquitination-31.3021906983
88PhosphorylationLGRIMNLTVMLDTAL
HHHHHCHHHHHHHHC		10.0020068231
93PhosphorylationNLTVMLDTALGKPRE
CHHHHHHHHCCCCCE		21.5920068231
97 (in isoform 1)Ubiquitination-41.5721906983
97UbiquitinationMLDTALGKPREVFRL
HHHHHCCCCCEEECC		41.572190698
106PhosphorylationREVFRLPTDLTACDN
CEEECCCCCCCCCCC		48.5123403867
109PhosphorylationFRLPTDLTACDNRLC
ECCCCCCCCCCCCEE		28.2223403867
193UbiquitinationRIEKEELDMKGSGFY
HHHHHHHCCCCCEEE		39.7729967540
222UbiquitinationNKKYEIIKRDILRGK
CCCEEEEEHHHHCCC		50.0729967540
229UbiquitinationKRDILRGKSVPHYAA
EHHHHCCCCCCEEEE		41.67-
251PhosphorylationLMIVSYKSLTFVQAG
EEEEEEEEEEEEECC		25.1427251275
253PhosphorylationIVSYKSLTFVQAGQD
EEEEEEEEEEECCCC		28.9327251275
270PhosphorylationENMDEDISEKIKEPL
HCCCCCHHHHHHCCC		45.2025159151
290PhosphorylationTEDDLTVTIRLPEDS
CCCCEEEEEECCCCC		8.6424719451
321UbiquitinationVLKDHQFLEGKLYSS
EECCCHHHCCEEEEE		7.3529967540
322UbiquitinationLKDHQFLEGKLYSSI
ECCCHHHCCEEEEEC		56.4229967540
327PhosphorylationFLEGKLYSSIDHESS
HHCCEEEEECCCCCC		31.1128348404
328PhosphorylationLEGKLYSSIDHESST
HCCEEEEECCCCCCE		20.6228348404
336UbiquitinationIDHESSTWIIKESNS
CCCCCCEEEEEECCC		7.7029967540
347PhosphorylationESNSLEISLIKKNEG
ECCCEEEEEEECCCC		18.0524719451
350UbiquitinationSLEISLIKKNEGLTW
CEEEEEEECCCCCCC		55.6429967540
351UbiquitinationLEISLIKKNEGLTWP
EEEEEEECCCCCCCC		53.9229967540
356PhosphorylationIKKNEGLTWPELVIG
EECCCCCCCCEEEEE		50.2430576142
365UbiquitinationPELVIGDKQGELIRD
CEEEEECCCCCCHHH		55.8029967540
373PhosphorylationQGELIRDSAQCAAIA
CCCCHHHHHHHHHHH		15.4726462736
387PhosphorylationAERLMHLTSEELNPN
HHHHHHHCHHHHCCC		21.2925159151
388PhosphorylationERLMHLTSEELNPNP
HHHHHHCHHHHCCCC		35.1211416219
430PhosphorylationFDGNTLKTTHVVNLG
ECCCEEEEEEEEECC		25.8324719451
431PhosphorylationDGNTLKTTHVVNLGS
CCCEEEEEEEEECCC		15.8724719451
438PhosphorylationTHVVNLGSNQYLFSV
EEEEECCCCCEEEEE		24.7528348404
444PhosphorylationGSNQYLFSVIVDPKE
CCCCEEEEEEECCCC		14.3524719451
496AcetylationVQASKRDKKFFACAP
EECCCCCCCEEEECC		56.3525953088
515UbiquitinationAALCECLRRVFIYRQ
HHHHHHHHHHHHCCC		44.3629967540
544UbiquitinationRQVGQVAKQQVASLE
CCHHHHHHHHHHCCC		42.2729967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NUDC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NUDC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NUDC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDC10_HUMANPDCD10physical
22863883
PLD3_HUMANPLD3physical
22863883
TYPH_HUMANTYMPphysical
22863883
UBA5_HUMANUBA5physical
22863883
DHX8_HUMANDHX8physical
25036637
PRP16_HUMANDHX38physical
25036637
DHX16_HUMANDHX16physical
25036637
COPB_HUMANCOPB1physical
25036637
COPG2_HUMANCOPG2physical
25036637
DHX40_HUMANDHX40physical
25036637
COPD_HUMANARCN1physical
25036637
DHX33_HUMANDHX33physical
25036637
COPZ1_HUMANCOPZ1physical
25036637
GLCM_HUMANGBAphysical
25036637
COPE_HUMANCOPEphysical
25036637
FUCM_HUMANFUOMphysical
25036637
COPA_HUMANCOPAphysical
25036637
COPB2_HUMANCOPB2physical
25036637
COPG1_HUMANCOPG1physical
25036637
DHX15_HUMANDHX15physical
25036637
DNHD1_HUMANDNHD1physical
25036637
VWA8_HUMANVWA8physical
25036637
NPT2B_HUMANSLC34A2physical
25036637
ERBB4_HUMANERBB4physical
25036637
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NUDC1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.

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