DHX40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX40_HUMAN
• UniProt AC: Q8IX18
• Protein Name: Probable ATP-dependent RNA helicase DHX40
• Gene Name: DHX40
• Organism: Homo sapiens (Human).
• Sequence Length: 779
• Protein Description: Probable ATP-dependent RNA helicase..
• Protein Sequence: MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDVLKKMQRRNDDKSISDARARFLERKQQRTQDHSDTRKETG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Methylation	-----MSRFPAVAGR -----CCCCCCCCCC	40.02	-
30	Phosphorylation	DLQEERLSAVCIADR HHHHHHHHHEEEECC	25.52	28555341
40	Ubiquitination	CIADREEKGCTSQEG EEECCHHCCCCCCCC	55.31	-
50	Phosphorylation	TSQEGGTTPTFPIQK CCCCCCCCCCCCCHH	24.49	25159151
57	Ubiquitination	TPTFPIQKQRKKIIQ CCCCCCHHHHHHHHH	53.44	-
61	Ubiquitination	PIQKQRKKIIQAVRD CCHHHHHHHHHHHHC	47.43	-
70	Phosphorylation	IQAVRDNSFLIVTGN HHHHHCCCEEEEECC	26.22	20873877
78	Phosphorylation	FLIVTGNTGSGKTTQ EEEEECCCCCCCCCC	33.79	-
82	Ubiquitination	TGNTGSGKTTQLPKY ECCCCCCCCCCCCHH	50.53	-
83	Phosphorylation	GNTGSGKTTQLPKYL CCCCCCCCCCCCHHH	24.25	-
84	Phosphorylation	NTGSGKTTQLPKYLY CCCCCCCCCCCHHHH	31.43	-
91	Phosphorylation	TQLPKYLYEAGFSQH CCCCHHHHHCCCCCC	10.72	21403953
91 (in isoform 2)	Ubiquitination	-	10.72	21890473
104	Phosphorylation	QHGMIGVTQPRKVAA CCCCCCCCCCCHHHH	27.87	21406692
108	Ubiquitination	IGVTQPRKVAAISVA CCCCCCCHHHHHHHH	42.80	-
123	Ubiquitination	QRVAEEMKCTLGSKV HHHHHHHCCCCCCCC	27.61	-
125	Phosphorylation	VAEEMKCTLGSKVGY HHHHHCCCCCCCCEE	28.74	28152594
128	Phosphorylation	EMKCTLGSKVGYQVR HHCCCCCCCCEEEEE	27.55	28152594
129	Ubiquitination	MKCTLGSKVGYQVRF HCCCCCCCCEEEEEE	37.57	-
142	Acetylation	RFDDCSSKETAIKYM EECCCCCCHHHHHHH	42.67	26051181
142	Ubiquitination	RFDDCSSKETAIKYM EECCCCCCHHHHHHH	42.67	-
148	Phosphorylation	SKETAIKYMTDGCLL CCHHHHHHHCCCCHH	10.11	29496907
156	Ubiquitination	MTDGCLLKHILGDPN HCCCCHHHHHHCCCC	18.69	-
168	Phosphorylation	DPNLTKFSVIILDEA CCCCCEEEEEEECHH	17.60	-
190 (in isoform 3)	Ubiquitination	-	53.09	21890473
190 (in isoform 1)	Ubiquitination	-	53.09	21890473
190	Ubiquitination	DILFGLLKKLFQEKS HHHHHHHHHHHHHCC	53.09	21906983
197	Phosphorylation	KKLFQEKSPNRKEHL HHHHHHCCCCHHHHH	27.01	30266825
240	Acetylation	RLYPVREKFCNLIGP CEECHHHHHHHCCCC	44.65	25953088
240	Ubiquitination	RLYPVREKFCNLIGP CEECHHHHHHHCCCC	44.65	-
340 (in isoform 2)	Ubiquitination	-	30.82	21890473
367	Ubiquitination	VVDGGFVKQLNHNPR EEECCHHHCCCCCCC	46.97	21890473
367 (in isoform 1)	Ubiquitination	-	46.97	21890473
367 (in isoform 3)	Ubiquitination	-	46.97	21890473
367	Ubiquitination	VVDGGFVKQLNHNPR EEECCHHHCCCCCCC	46.97	21890473
387	Ubiquitination	LEVVPISKSEALQRS EEEEECCHHHHHHHC	53.70	2190698
387 (in isoform 1)	Ubiquitination	-	53.70	21890473
387 (in isoform 3)	Ubiquitination	-	53.70	21890473
394	Phosphorylation	KSEALQRSGRAGRTS HHHHHHHCCCCCCCC	21.48	-
404	Ubiquitination	AGRTSSGKCFRIYSK CCCCCCCCEEEEEEH	31.95	-
410	Phosphorylation	GKCFRIYSKDFWNQC CCEEEEEEHHHHHHH	24.31	-
465	Ubiquitination	RLILEALKQLYQCDA HHHHHHHHHHHCCCC	45.35	-
468	Phosphorylation	LEALKQLYQCDAIDR HHHHHHHHCCCCCCC	12.47	24043423
534	Ubiquitination	PVDPEYQKEAEQRHR CCCHHHHHHHHHHHH	58.97	-
601	Ubiquitination	RELIRKLKQQSDFPK HHHHHHHHHCCCCCH	49.69	-
608	Ubiquitination	KQQSDFPKETFEGPK HHCCCCCHHHCCCHH	70.18	-
615	Ubiquitination	KETFEGPKHEVLRRC HHHCCCHHHHHHHHH	64.35	-
648	Phosphorylation	CTMDGRGSPVHIHPS EECCCCCCCEEECCC	23.53	25849741
724	Phosphorylation	EDARRRWTNKENVKQ HHHHHHHCCHHHHHH	34.30	27135362
730	Acetylation	WTNKENVKQLKDGIS HCCHHHHHHHHHCCC	62.59	25953088
733	Acetylation	KENVKQLKDGISKDV HHHHHHHHHCCCHHH	51.95	11921431
737	Phosphorylation	KQLKDGISKDVLKKM HHHHHCCCHHHHHHH	28.47	27135362
743	Acetylation	ISKDVLKKMQRRNDD CCHHHHHHHHHHCCC	35.78	11921443
768	Phosphorylation	LERKQQRTQDHSDTR HHHHHHHHCCCHHHH	33.73	-
772	Phosphorylation	QQRTQDHSDTRKETG HHHHCCCHHHHHCCC	49.30	-
774	Phosphorylation	RTQDHSDTRKETG-- HHCCCHHHHHCCC--	46.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFIT2_HUMAN	IFIT2	physical	22939629
IKKA_HUMAN	CHUK	physical	22939629
SNAA_HUMAN	NAPA	physical	22939629
HAUS7_HUMAN	HAUS7	physical	22939629
SPG21_HUMAN	SPG21	physical	22939629
MD2BP_HUMAN	MAD2L1BP	physical	22939629
PKN3_HUMAN	PKN3	physical	22939629
SPDLY_HUMAN	SPDL1	physical	22939629
PGLT1_HUMAN	POGLUT1	physical	22939629
MTDC_HUMAN	MTHFD2	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.