PLD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLD3_HUMAN
• UniProt AC: Q8IV08
• Protein Name: Phospholipase D3
• Gene Name: PLD3
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: May be involved in APP processing..
• Protein Sequence: MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MKPKLMYQELK ----CCCCCCCEECC	40.13	-
7	Phosphorylation	-MKPKLMYQELKVPA -CCCCCCCEECCCCC	14.85	21945579
11	Ubiquitination	KLMYQELKVPAEEPA CCCCEECCCCCCCCC	45.48	21906983
30	Ubiquitination	MNEIEAWKAAEKKAR HHHHHHHHHHHHHHH	44.78	21906983
97	N-linked_Glycosylation	PEGLDFPNASTGNPS CCCCCCCCCCCCCCC	46.66	19159218
132	N-linked_Glycosylation	FYWTLTNNDTHTQEP HEEECCCCCCCCCCC	50.77	19159218
157	Ubiquitination	QLQTLAPKGVNVRIA HHHHHCCCCCEEEEE	70.64	21906983
167	Ubiquitination	NVRIAVSKPSGPQPQ EEEEEEECCCCCCCH	36.28	21906983
216	Phosphorylation	QTHFYLGSANMDWRS CCCEEECCCCCCHHH	17.55	-
223	Phosphorylation	SANMDWRSLTQVKEL CCCCCHHHHHHHHHH	31.36	29759185
225	Phosphorylation	NMDWRSLTQVKELGV CCCHHHHHHHHHHCE	32.34	29759185
235	Phosphorylation	KELGVVMYNCSCLAR HHHCEEEEEHHHHHH	11.04	29759185
238	Phosphorylation	GVVMYNCSCLARDLT CEEEEEHHHHHHHHH	14.45	29759185
294	O-linked_Glycosylation	PALAYLASAPPPLCP HHHHHHHCCCCCCCC	38.42	OGP
309	Ubiquitination	SGRTPDLKALLNVVD CCCCCCHHHHHHHHH	44.35	21906983
380	Phosphorylation	SMRAFLLSLAALRDN HHHHHHHHHHHHHCC	20.36	29116813
389	Phosphorylation	AALRDNHTHSDIQVK HHHHCCCCCCCCEEE	29.36	29116813
391	Phosphorylation	LRDNHTHSDIQVKLF HHCCCCCCCCEEEEE	37.25	30206219
426	Phosphorylation	YMVTERATYIGTSNW EEEEECEEEEECCCC	23.15	24719451
430	Phosphorylation	ERATYIGTSNWSGNY ECEEEEECCCCCCCC	14.88	24719451
434	Phosphorylation	YIGTSNWSGNYFTET EEECCCCCCCCEECC	22.78	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRH3_HUMAN	HNRNPH3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615711: Alzheimer disease 19 (AD19)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-97 AND ASN-132, AND MASSSPECTROMETRY.
PubMed: 19159218