dbPTM

NPT2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NPT2B_HUMAN
UniProt AC	O95436
Protein Name	Sodium-dependent phosphate transport protein 2B
Gene Name	SLC34A2
Organism	Homo sapiens (Human).
Sequence Length	690
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli..
Protein Sequence	MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	AQPNPDKYLEGAAGQ CCCCHHHHHCCCCCC	19.84	22817900
53	Phosphorylation	TKIELLPSYSTATLI EEEEECCCCCEEEEE	31.52	19060867
54	Phosphorylation	KIELLPSYSTATLID EEEECCCCCEEEEEC	14.22	22817900
55	Phosphorylation	IELLPSYSTATLIDE EEECCCCCEEEEECC	18.86	19060867
56	Phosphorylation	ELLPSYSTATLIDEP EECCCCCEEEEECCC	18.54	28348404
58	Phosphorylation	LPSYSTATLIDEPTE CCCCCEEEEECCCCC	25.08	27251275
295	N-linked_Glycosylation	MNDEKAKNKSLVKIW CCCHHHCCCHHHEEH	43.97	UniProtKB CARBOHYD
308	N-linked_Glycosylation	IWCKTFTNKTQINVT EHHHCCCCCCEEEEE	40.98	UniProtKB CARBOHYD
313	N-linked_Glycosylation	FTNKTQINVTVPSTA CCCCCEEEEEECCCC	17.37	UniProtKB CARBOHYD
321	N-linked_Glycosylation	VTVPSTANCTSPSLC EEECCCCCCCCCCCE	29.68	UniProtKB CARBOHYD
340	N-linked_Glycosylation	IQNWTMKNVTYKENI CCCCCCCCCCHHHHH	22.12	UniProtKB CARBOHYD
503	Phosphorylation	ISGILLWYPIPFTRL CCCEEEEEECCCCHH	7.40	-
508	Phosphorylation	LWYPIPFTRLPIRMA EEEECCCCHHHHHHC	26.41	-
669	Phosphorylation	PETFDNITISREAQG CCCCCCEEEEHHHCC	21.10	28355574
671	Phosphorylation	TFDNITISREAQGEV CCCCEEEEHHHCCCC	18.54	24719451
681	Phosphorylation	AQGEVPASDSKTECT HCCCCCCCCCCCCCC	36.03	22617229
683	Phosphorylation	GEVPASDSKTECTAL CCCCCCCCCCCCCCC	38.69	28348404
685	Phosphorylation	VPASDSKTECTAL-- CCCCCCCCCCCCC--	40.00	28348404
687	Phosphorylation	ASDSKTECTAL---- CCCCCCCCCCC----	3.06	33259812
688	Phosphorylation	SDSKTECTAL----- CCCCCCCCCC-----	25.43	33259812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NPT2B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NPT2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NPT2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCD10_HUMAN	PCDH10	physical	28514442
ENDD1_HUMAN	ENDOD1	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
LMTK2_HUMAN	LMTK2	physical	28514442
VPP1_HUMAN	ATP6V0A1	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
AT11C_HUMAN	ATP11C	physical	28514442
VPP2_HUMAN	ATP6V0A2	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
CA2D1_HUMAN	CACNA2D1	physical	28514442
ZNT7_HUMAN	SLC30A7	physical	28514442

Drug and Disease Associations

Kegg Disease
H00014	Non-small cell lung cancer
H01298	Pulmonary alveolar microlithiasis (PALM)
OMIM Disease
265100	Pulmonary alveolar microlithiasis (PALM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NPT2B_HUMAN

Related Literatures of Post-Translational Modification