MPND_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPND_HUMAN
• UniProt AC: Q8N594
• Protein Name: MPN domain-containing protein
• Gene Name: MPND
• Organism: Homo sapiens (Human).
• Sequence Length: 471
• Protein Description: Probable protease..
• Protein Sequence: MAAPEPLSPAGGAGEEAPEEDEDEAEAEDPERPNAGAGGGRSGGGGSSVSGGGGGGGAGAGGCGGPGGALTRRAVTLRVLLKDALLEPGAGVLSIYYLGKKFLGDLQPDGRIMWQETGQTFNSPSAWATHCKKLVNPAKKSGCGWASVKYKGQKLDKYKATWLRLHQLHTPATAADESPASEGEEEELLMEEEEEDVLAGVSAEDKSRRPLGKSPSEPAHPEATTPGKRVDSKIRVPVRYCMLGSRDLARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLLDFHSHLTRSEVVGYLGGRWDVNSQMLTVLRAFPCRSRLGDAETAAAIEEEIYQSLFLRGLSLVGWYHSHPHSPALPSLQDIDAQMDYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESKISPFWVMPPPEMLLVEFYKGSPDLVRLQEPWSQEHTYLDKLKISLASRTPKDQSLCHVLEQVCGVLKQGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAPEPLSP ------CCCCCCCCC	31.55	21406692
8	Phosphorylation	MAAPEPLSPAGGAGE CCCCCCCCCCCCCCC	24.34	28355574
42	Phosphorylation	AGAGGGRSGGGGSSV CCCCCCCCCCCCCCC	45.10	28111955
47	Phosphorylation	GRSGGGGSSVSGGGG CCCCCCCCCCCCCCC	30.73	28111955
48	Phosphorylation	RSGGGGSSVSGGGGG CCCCCCCCCCCCCCC	24.47	28111955
50	Phosphorylation	GGGGSSVSGGGGGGG CCCCCCCCCCCCCCC	33.40	28111955
71	Phosphorylation	GGPGGALTRRAVTLR CCCCCHHHHHHHHHH	19.99	28111955
76	Phosphorylation	ALTRRAVTLRVLLKD HHHHHHHHHHHHHHH	14.09	23532336
101	Ubiquitination	SIYYLGKKFLGDLQP EEEEECHHCCCCCCC	43.98	-
120	Phosphorylation	MWQETGQTFNSPSAW EEEECCCCCCCHHHH	26.57	26714015
123	Phosphorylation	ETGQTFNSPSAWATH ECCCCCCCHHHHHHH	18.95	25159151
125	Phosphorylation	GQTFNSPSAWATHCK CCCCCCHHHHHHHHH	35.94	26714015
140	Ubiquitination	KLVNPAKKSGCGWAS HHCCHHHHCCCCCCC	54.94	-
141	Phosphorylation	LVNPAKKSGCGWASV HCCHHHHCCCCCCCC	38.31	29083192
147	Phosphorylation	KSGCGWASVKYKGQK HCCCCCCCCEECCEE	16.78	29083192
150	Phosphorylation	CGWASVKYKGQKLDK CCCCCCEECCEECHH	20.42	29083192
170	Phosphorylation	LRLHQLHTPATAADE EEHHHCCCCCCCCCC	24.18	27251275
173	Phosphorylation	HQLHTPATAADESPA HHCCCCCCCCCCCCC	24.47	27251275
178	Phosphorylation	PATAADESPASEGEE CCCCCCCCCCCCCHH	26.72	17081983
181	Phosphorylation	AADESPASEGEEEEL CCCCCCCCCCHHHHH	49.90	17081983
202	Phosphorylation	EDVLAGVSAEDKSRR HHHHHCCCCCCCCCC	25.64	21406692
213	Ubiquitination	KSRRPLGKSPSEPAH CCCCCCCCCCCCCCC	67.86	-
214	Phosphorylation	SRRPLGKSPSEPAHP CCCCCCCCCCCCCCC	31.68	30266825
216	Phosphorylation	RPLGKSPSEPAHPEA CCCCCCCCCCCCCCC	64.40	25849741
224	Phosphorylation	EPAHPEATTPGKRVD CCCCCCCCCCCCCCC	31.68	25849741
225	Phosphorylation	PAHPEATTPGKRVDS CCCCCCCCCCCCCCC	36.77	29255136
228	Ubiquitination	PEATTPGKRVDSKIR CCCCCCCCCCCCCCC	50.91	-
245	Phosphorylation	VRYCMLGSRDLARNP CEEEECCCHHHCCCC	20.75	27251275
334	Phosphorylation	AAIEEEIYQSLFLRG HHHHHHHHHHHHHHC	8.70	-
391	Phosphorylation	LALLCSPYYSGNPGP HHHHHCCCCCCCCCC	8.25	28985074
392	Phosphorylation	ALLCSPYYSGNPGPE HHHHCCCCCCCCCCC	17.31	28985074
393	Phosphorylation	LLCSPYYSGNPGPES HHHCCCCCCCCCCCC	26.67	28985074
421 (in isoform 2)	Ubiquitination	-	32.79	-
422	Phosphorylation	LVEFYKGSPDLVRLQ EEEECCCCCCCEECC	15.87	27251275
441	Ubiquitination	QEHTYLDKLKISLAS CCCCHHHHHHHHHCC	49.43	-
443	Ubiquitination	HTYLDKLKISLASRT CCHHHHHHHHHCCCC	35.67	-
452	Ubiquitination	SLASRTPKDQSLCHV HHCCCCCCCHHHHHH	68.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPND_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPND_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPND_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MPND_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-181, ANDMASS SPECTROMETRY.
PubMed: 17081983