RN128_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN128_MOUSE
• UniProt AC: Q9D304
• Protein Name: E3 ubiquitin-protein ligase RNF128
• Gene Name: Rnf128
• Organism: Mus musculus (Mouse).
• Sequence Length: 428
• Subcellular Localization: Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partiall
• Protein Description: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity)..
• Protein Sequence: MGPPPGIGVYCRGGCGAARLLAWCFLLALSPHAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVSGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTFADKIHLASERGASGAVIFNFPGTRNEVIPMSHPGAGDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGKLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEASNTASPHEEDSRSETASSGYASVQGADEPPLEEHAQSANENLQLVNHEANSVAVDVVPHVDNPTFEEDETPDQEAAVREIKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	N-linked_Glycosylation	AVWTAYLNVSWRVPH EEEEEEEEEEEECCC	17.07	-
59	N-linked_Glycosylation	RVPHTGVNRTVWELS ECCCCCCCCEEEEEC	34.94	-
101	N-linked_Glycosylation	NACNPHTNFTVPTVW HCCCCCCCCCCCCCC	27.79	-
151	Phosphorylation	VIFNFPGTRNEVIPM EEECCCCCCCCEECC	30.47	-
159	Phosphorylation	RNEVIPMSHPGAGDI CCCEECCCCCCCCCE	22.60	-
257	Ubiquitination	DAKKAIGKLQLRTLK HHHHHHHHHHHHHHH	27.26	-
323	Ubiquitination	MCKCDILKALGIEVD CCCCHHHHHHCCEEE	41.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN128_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN128_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN128_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_MOUSE	Trp53	physical	23370271
TBK1_MOUSE	Tbk1	physical	27776110

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.