INP4A_HUMAN - dbPTM
INP4A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INP4A_HUMAN
UniProt AC Q96PE3
Protein Name Type I inositol 3,4-bisphosphate 4-phosphatase
Gene Name INPP4A
Organism Homo sapiens (Human).
Sequence Length 977
Subcellular Localization
Protein Description Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate..
Protein Sequence MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPSTMPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationARAMQRASTIDVAAD
HHHHHHHHHHHHHHH		28.25-
22PhosphorylationRAMQRASTIDVAADM
HHHHHHHHHHHHHHH		21.88-
123UbiquitinationKLSVYDVKDRSQGTM
EEEEEECCCCCCCEE		44.52-
123 (in isoform 3)Ubiquitination-44.52-
137PhosphorylationMYLLGSGTFIVKDLL
EEEECCCEEEEEHHH		16.3418491316
147MethylationVKDLLQDRHHRLHLT
EEHHHCCCCCCHHEE		17.98115480363
157PhosphorylationRLHLTLRSAESDRVG
CHHEEECCCCCCCCC		39.2329759185
160PhosphorylationLTLRSAESDRVGNIT
EEECCCCCCCCCEEE		30.3619053533
177PhosphorylationGWQMEEKSDQRPPVT
EEEECCCCCCCCCCC		42.1128555341
184PhosphorylationSDQRPPVTRSVDTVN
CCCCCCCCEEEEEEC		24.0128555341
210PhosphorylationTEALGIRSKYASLRK
HHHHCCHHHHHHHCH		28.2624117733
211UbiquitinationEALGIRSKYASLRKD
HHHCCHHHHHHHCHH		34.68-
212PhosphorylationALGIRSKYASLRKDT
HHCCHHHHHHHCHHH		11.5823882029
214PhosphorylationGIRSKYASLRKDTLL
CCHHHHHHHCHHHHH		26.1424117733
219PhosphorylationYASLRKDTLLKSVFG
HHHHCHHHHHHHHHC		36.7023882029
222UbiquitinationLRKDTLLKSVFGGAI
HCHHHHHHHHHCCCC		47.92-
222 (in isoform 3)Ubiquitination-47.92-
233PhosphorylationGGAICRMYRFPTTDG
CCCCCCEEECCCCCC		6.9730206219
237PhosphorylationCRMYRFPTTDGNHLR
CCEEECCCCCCCHHH		34.5030206219
238PhosphorylationRMYRFPTTDGNHLRI
CEEECCCCCCCHHHH		41.9930206219
252PhosphorylationILEQMAESVLSLHVP
HHHHHHHHHHHCCCC		20.86-
321MethylationQYRGPSFKASSLKAD
HHCCCCCCHHHCCCC		52.267714505
3262-HydroxyisobutyrylationSFKASSLKADKKLEF
CCCHHHCCCCCCCEE		57.39-
330UbiquitinationSSLKADKKLEFVPTN
HHCCCCCCCEECCCC		54.52-
351PhosphorylationRVQDDGGSDQNYDIV
EEECCCCCCCCEEEE		41.3728796482
355PhosphorylationDGGSDQNYDIVTIGA
CCCCCCCEEEEEECC		11.0428796482
359PhosphorylationDQNYDIVTIGAPAAH
CCCEEEEEECCCCHH		17.6426552605
371 (in isoform 3)Ubiquitination-55.82-
371UbiquitinationAAHCQGFKSGGLRKK
CHHCCCHHCCCHHHH		55.82-
387 (in isoform 3)Ubiquitination-62.03-
394PhosphorylationKHFEECCTSSGCQSI
HHHHHHHHCCCCCEE		37.27-
395PhosphorylationHFEECCTSSGCQSII
HHHHHHHCCCCCEEE		15.72-
407 (in isoform 3)Ubiquitination-35.21-
412UbiquitinationPQDVVRAKEIIAQIN
CHHHHCHHHHHHHHH		38.59-
426PhosphorylationNTLKTQVSYYAERLS
HHHHHHHHHHHHHHH		11.5630576142
427PhosphorylationTLKTQVSYYAERLSR
HHHHHHHHHHHHHHH		14.0830576142
428PhosphorylationLKTQVSYYAERLSRA
HHHHHHHHHHHHHHH		8.4230576142
433PhosphorylationSYYAERLSRAAKDRS
HHHHHHHHHHHHHHC		26.54-
449 (in isoform 3)Ubiquitination-8.30-
454UbiquitinationTLAILADKTRQLVTV
HHHHHHHCCCCEEEH		39.74-
460 (in isoform 3)Ubiquitination-24.82-
465UbiquitinationLVTVCDCKLLANSIH
EEEHHHHHHHHHHHC		33.03-
481PhosphorylationLNAARPDYIASKASP
HHHCCCCCEECCCCC		10.8928796482
484PhosphorylationARPDYIASKASPTST
CCCCCEECCCCCCCC		21.1324719451
485UbiquitinationRPDYIASKASPTSTE
CCCCEECCCCCCCCH		43.81-
487PhosphorylationDYIASKASPTSTEEE
CCEECCCCCCCCHHH		32.2329255136
489PhosphorylationIASKASPTSTEEEQV
EECCCCCCCCHHHHH		45.8729255136
490PhosphorylationASKASPTSTEEEQVM
ECCCCCCCCHHHHHH		36.8929255136
491PhosphorylationSKASPTSTEEEQVML
CCCCCCCCHHHHHHH		50.3129255136
497SulfoxidationSTEEEQVMLRNDQDT
CCHHHHHHHHCCHHC		2.6521406390
504PhosphorylationMLRNDQDTLMARWTG
HHHCCHHCCHHHHCC		16.8924719451
510PhosphorylationDTLMARWTGRNSRSS
HCCHHHHCCCCCCCC		22.2527251275
514PhosphorylationARWTGRNSRSSLQVD
HHHCCCCCCCCCEEE		31.9824719451
516PhosphorylationWTGRNSRSSLQVDWH
HCCCCCCCCCEEECC		34.9130576142
517PhosphorylationTGRNSRSSLQVDWHE
CCCCCCCCCEEECCH		23.0130576142
536UbiquitinationKVWLNVDKSLECIIQ
HHEECHHHHHHHHHH		53.29-
546 (in isoform 3)Ubiquitination-37.77-
547UbiquitinationCIIQRVDKLLQKERL
HHHHHHHHHHHHHHH		48.52-
551UbiquitinationRVDKLLQKERLHGEG
HHHHHHHHHHHCCCC		44.78-
567 (in isoform 3)Ubiquitination-29.94-
568 (in isoform 3)Ubiquitination-8.83-
568PhosphorylationDVFPCAGSCTSKKGN
CCCCCCCCCCCCCCC		8.8328555341
660PhosphorylationVFLLMQDSAPTIATY
HHHHHCCCHHHHHHH		21.1822210691
681PhosphorylationRDVVFCQTLTALICG
CHHHHHHHHHHHHHH		27.5322210691
745UbiquitinationDLRNVTFKVTQATSS
EHHCCEEEEEECCCC		34.70-
747O-linked_GlycosylationRNVTFKVTQATSSAS
HCCEEEEEECCCCCC		17.0530379171
851PhosphorylationDCLPRSRSQTCLPEL
HHCCCCCCCCHHHHH		30.96-
903 (in isoform 4)Phosphorylation-6.8023909892
908 (in isoform 4)Phosphorylation-3.9223909892
920 (in isoform 2)Ubiquitination-5.4721890473
942PhosphorylationEGCRRENTMKNVGSR
CCCCCCCCCCCCCCH		25.44-
951PhosphorylationKNVGSRKYAFNSLQL
CCCCCHHHHCHHHCC		18.4720068231
954 (in isoform 3)Ubiquitination-33.3721890473
955PhosphorylationSRKYAFNSLQLKAFP
CHHHHCHHHCCEECC		15.8425159151
959 (in isoform 1)Ubiquitination-34.7121890473
959UbiquitinationAFNSLQLKAFPKHYR
HCHHHCCEECCCCCC		34.7121890473
963UbiquitinationLQLKAFPKHYRPPEG
HCCEECCCCCCCCCC		46.98-
965PhosphorylationLKAFPKHYRPPEGTY
CEECCCCCCCCCCCC		30.8218083107
969 (in isoform 3)Ubiquitination-67.84-
971PhosphorylationHYRPPEGTYGKVET-
CCCCCCCCCCCCCC-		27.6928796482
972PhosphorylationYRPPEGTYGKVET--
CCCCCCCCCCCCC--		26.3028796482
974UbiquitinationPPEGTYGKVET----
CCCCCCCCCCC----		26.87-
977PhosphorylationGTYGKVET-------
CCCCCCCC-------		100.0029978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INP4A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INP4A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INP4A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of INP4A_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INP4A_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory