dbPTM

VIF_HV1B1 - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VIF_HV1B1
UniProt AC	P69720
Protein Name	Virion infectivity factor {ECO:0000255\|HAMAP-Rule:MF_04081}
Gene Name	vif {ECO:0000255\|HAMAP-Rule:MF_04081}
Organism	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1).
Sequence Length	192
Subcellular Localization	Host cytoplasm . Host cell membrane Peripheral membrane protein Cytoplasmic side . Virion . In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presu
Protein Description	Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells..
Protein Sequence	MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	WRKKRYSTQVDPELA EHHHHCCCCCCHHHH	24.55	-
144	Phosphorylation	AGHNKVGSLQYLALA CCCCCCHHHHHHHHH	18.45	-
155	Phosphorylation	LALAALITPKKIKPP HHHHHHHCCCCCCCC	29.88	-
165	Phosphorylation	KIKPPLPSVTKLTED CCCCCCCCCCCCCCC	50.53	-
188	Phosphorylation	KGHRGSHTMNGH--- CCCCCCCCCCCC---	17.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
96	T	Phosphorylation	Kinase	MAP4K1	-	Uniprot
165	S	Phosphorylation	Kinase	MAP4K1	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VIF_HV1B1 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VIF_HV1B1 !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX6_HUMAN	DDX6	physical	17898068
CUL5_HUMAN	CUL5	physical	17898068
ELOB_HUMAN	TCEB2	physical	17898068
ELOC_HUMAN	TCEB1	physical	17898068
RN216_HUMAN	RNF216	physical	12600646
SAT1_HUMAN	SAT1	physical	12600646
CUL5_HUMAN	CUL5	physical	16636053
AICDA_HUMAN	AICDA	physical	16580072
MDM2_HUMAN	MDM2	physical	19128510
ABC3G_HUMAN	APOBEC3G	physical	21279453
ABC3G_HUMAN	APOBEC3G	physical	21228271
P53_HUMAN	TP53	physical	21071676
ABC3G_HUMAN	APOBEC3G	physical	21071676
CUL5_HUMAN	CUL5	physical	17869271
ELOB_HUMAN	TCEB2	physical	17869271
ELOC_HUMAN	TCEB1	physical	17869271
ELOC_HUMAN	TCEB1	physical	20532212
ELOB_HUMAN	TCEB2	physical	20532212
CUL5_HUMAN	CUL5	physical	20463065
VIF_HV1B1	vif	physical	20463065
VIF_HV1BR	vif	physical	20463065
VIF_HV1H2	vif	physical	20463065
ABC3G_HUMAN	APOBEC3G	physical	18680593
ABC3G_HUMAN	APOBEC3G	physical	18326044
CUL5_HUMAN	CUL5	physical	18326044
CUL5_HUMAN	CUL5	physical	15781449
ELOB_HUMAN	TCEB2	physical	15781449
ELOC_HUMAN	TCEB1	physical	15781449
RBX1_HUMAN	RBX1	physical	15781449
ABC3G_HUMAN	APOBEC3G	physical	15781449
ABC3G_HUMAN	APOBEC3G	physical	15611076
UBC_HUMAN	UBC	physical	15574592
ELOC_HUMAN	TCEB1	physical	15574592
CUL5_HUMAN	CUL5	physical	15574592
ABC3G_HUMAN	APOBEC3G	physical	15574592
ABC3G_HUMAN	APOBEC3G	physical	14672928
ABC3F_HUMAN	APOBEC3F	physical	21279453
ABC3C_HUMAN	APOBEC3C	physical	21279453
CUL5_HUMAN	CUL5	physical	14564014
ELOB_HUMAN	TCEB2	physical	14564014
ELOC_HUMAN	TCEB1	physical	14564014
ABC3G_HUMAN	APOBEC3G	physical	14564014
ABC3G_HUMAN	APOBEC3G	physical	19109396
CUL5_HUMAN	CUL5	physical	19588889
CUL5_HUMAN	CUL5	physical	16530799
ELOB_HUMAN	TCEB2	physical	16530799
ELOC_HUMAN	TCEB1	physical	16530799
ABC3G_HUMAN	APOBEC3G	physical	16530799
ELOB_HUMAN	TCEB2	physical	18562529
ELOC_HUMAN	TCEB1	physical	18562529
CUL5_HUMAN	CUL5	physical	18562529
VIF_HV1B1	vif	physical	18562529
VIF_HV1BR	vif	physical	18562529
VIF_HV1H2	vif	physical	18562529
DCAF1_HUMAN	VPRBP	physical	19923175
ABC3F_HUMAN	APOBEC3F	physical	16014920
ABC3G_HUMAN	APOBEC3G	physical	18499212
CUL5_HUMAN	CUL5	physical	15574593
ELOC_HUMAN	TCEB1	physical	15574593
ELOB_HUMAN	TCEB2	physical	15574593
ABC3G_HUMAN	APOBEC3G	physical	15574593
NEDD4_HUMAN	NEDD4	physical	15013426
ITCH_HUMAN	ITCH	physical	15013426
UBC_HUMAN	UBC	physical	15013426
ABC3G_HUMAN	APOBEC3G	physical	20335268
ABC3F_HUMAN	APOBEC3F	physical	20335268
VIF_HV1B1	vif	physical	22369580
VIF_HV1BR	vif	physical	22369580
VIF_HV1H2	vif	physical	22369580
CUL5_HUMAN	CUL5	physical	17135358
ELOB_HUMAN	TCEB2	physical	17135358
ELOC_HUMAN	TCEB1	physical	17135358
ABC3G_HUMAN	APOBEC3G	physical	17135358
ABC3G_HUMAN	APOBEC3G	physical	18619467
ABC3F_HUMAN	APOBEC3F	physical	18619467
ABC3G_HUMAN	APOBEC3G	physical	19088851
ABC3G_HUMAN	APOBEC3G	physical	19535450
RN216_HUMAN	RNF216	physical	15367624
CUL5_HUMAN	CUL5	physical	22190037
DDB1_HUMAN	DDB1	physical	22190037
ELOC_HUMAN	TCEB1	physical	22190037
ELOB_HUMAN	TCEB2	physical	22190037
VIF_HV1B1	vif	physical	22190037
VIF_HV1BR	vif	physical	22190037
VIF_HV1H2	vif	physical	22190037
PEBB_HUMAN	CBFB	physical	22190037
RBX2_HUMAN	RNF7	physical	22190037
CUL2_HUMAN	CUL2	physical	22190037
SQSTM_HUMAN	SQSTM1	physical	22190037
UBR2_HUMAN	UBR2	physical	22190037
CHIP_HUMAN	STUB1	physical	22190037
PSME3_HUMAN	PSME3	physical	22190037
HDAC3_HUMAN	HDAC3	physical	22190037
DCA11_HUMAN	DCAF11	physical	22190037
GPS2_HUMAN	GPS2	physical	22190037
UBL4A_HUMAN	UBL4A	physical	22190037
ABC3G_HUMAN	APOBEC3G	physical	22190037
CUL5_HUMAN	CUL5	physical	22190036
ELOC_HUMAN	TCEB1	physical	22190036
ELOB_HUMAN	TCEB2	physical	22190036
PEBB_HUMAN	CBFB	physical	22190036
CUL5_HUMAN	CUL5	physical	21149631
CDK9_HUMAN	CDK9	physical	21149631
HNRPL_HUMAN	HNRNPL	physical	21149631
HNRPU_HUMAN	HNRNPU	physical	21149631
PRP19_HUMAN	PRPF19	physical	21149631
CAND1_HUMAN	CAND1	physical	21149631
DHX9_HUMAN	DHX9	physical	21149631
DDX21_HUMAN	DDX21	physical	21149631
BRD4_HUMAN	BRD4	physical	21149631
ELOC_HUMAN	TCEB1	physical	22190034
PEBB_HUMAN	CBFB	physical	22190034
ELOB_HUMAN	TCEB2	physical	22190034
RBX2_HUMAN	RNF7	physical	22190034
AMRA1_HUMAN	AMBRA1	physical	22190034
CUL5_HUMAN	CUL5	physical	22190034
CUL2_HUMAN	CUL2	physical	22190034
DNJC7_HUMAN	DNAJC7	physical	22190034
SQSTM_HUMAN	SQSTM1	physical	22190034
HUWE1_HUMAN	HUWE1	physical	22190034
UBR2_HUMAN	UBR2	physical	22190034
CHIP_HUMAN	STUB1	physical	22190034
PSME3_HUMAN	PSME3	physical	22190034
NCOR1_HUMAN	NCOR1	physical	22190034
HDAC3_HUMAN	HDAC3	physical	22190034
MAGD1_HUMAN	MAGED1	physical	22190034
TBL1R_HUMAN	TBL1XR1	physical	22190034
DCA11_HUMAN	DCAF11	physical	22190034
AKP8L_HUMAN	AKAP8L	physical	22190034
BAG6_HUMAN	BAG6	physical	22190034
GPS2_HUMAN	GPS2	physical	22190034
DNJB2_HUMAN	DNAJB2	physical	22190034
MK06_HUMAN	MAPK6	physical	22190034
UBL4A_HUMAN	UBL4A	physical	22190034
CUL5_HUMAN	CUL5	physical	23988114
PEBB_HUMAN	CBFB	physical	23988114
ELOC_HUMAN	TCEB1	physical	23988114
ELOB_HUMAN	TCEB2	physical	23988114
ELOC_HUMAN	TCEB1	physical	24225024
ELOB_HUMAN	TCEB2	physical	24225024
CUL5_HUMAN	CUL5	physical	24422669
PEBB_HUMAN	CBFB	physical	24422669
ELOB_HUMAN	TCEB2	physical	24422669
CUL5_HUMAN	CUL5	physical	24390335
PEBB_HUMAN	CBFB	physical	24390335
ELOB_HUMAN	TCEB2	physical	24390335
PEBB_HUMAN	CBFB	physical	24390320
ELOB_HUMAN	TCEB2	physical	24390320
CUL5_HUMAN	CUL5	physical	24390320
ELOC_HUMAN	TCEB1	physical	24390320
RBX2_HUMAN	RNF7	physical	24390320
ABC3F_HUMAN	APOBEC3F	physical	24390320
CUL5_HUMAN	CUL5	physical	24735396
CUL5_HUMAN	CUL5	physical	24402281
ELOB_HUMAN	TCEB2	physical	24402281
ELOC_HUMAN	TCEB1	physical	24402281
PEBB_HUMAN	CBFB	physical	24402281
PEBB_HUMAN	CBFB	physical	22479405
ELOC_HUMAN	TCEB1	physical	22479405
ELOB_HUMAN	TCEB2	physical	22479405
ABC3G_HUMAN	APOBEC3G	physical	23300442
PEBB_HUMAN	CBFB	physical	23333304
ELOB_HUMAN	TCEB2	physical	23333304
ELOC_HUMAN	TCEB1	physical	23333304
ABC3G_HUMAN	APOBEC3G	physical	23333304
CUL5_HUMAN	CUL5	physical	24810617
ELOB_HUMAN	TCEB2	physical	24810617
PEBB_HUMAN	CBFB	physical	24810617
ABC3G_HUMAN	APOBEC3G	physical	24810617
ABC3F_HUMAN	APOBEC3F	physical	24810617
HDAC6_HUMAN	HDAC6	physical	26105074
ABC3G_HUMAN	APOBEC3G	physical	26105074
M3K5_HUMAN	MAP3K5	physical	25901786
ELOB_HUMAN	TCEB2	physical	25901786
ELOC_HUMAN	TCEB1	physical	25901786
RUNX1_HUMAN	RUNX1	physical	25901786
CUL5_HUMAN	CUL5	physical	25901786
PEBB_HUMAN	CBFB	physical	25912140
ELOC_HUMAN	TCEB1	physical	25912140
ELOB_HUMAN	TCEB2	physical	25912140
ABC3G_HUMAN	APOBEC3G	physical	25912140
PEBB_HUMAN	CBFB	physical	27758855
MDM2_HUMAN	MDM2	physical	27758855

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VIF_HV1B1

Related Literatures of Post-Translational Modification