SPCS_HUMAN - dbPTM
SPCS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPCS_HUMAN
UniProt AC Q9HD40
Protein Name O-phosphoseryl-tRNA(Sec) selenium transferase
Gene Name SEPSECS
Organism Homo sapiens (Human).
Sequence Length 501
Subcellular Localization Cytoplasm .
Protein Description Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis..
Protein Sequence MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDNVLLDTYQDASS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MNRESFAAGERL
---CCHHHHHCCCCC		19.5628857561
8 (in isoform 3)Phosphorylation-20.5424043423
14PhosphorylationAAGERLVSPAYVRQG
HCCCCCCCHHHHHCC		14.3828857561
17 (in isoform 3)Phosphorylation-10.2724043423
23 (in isoform 3)Phosphorylation-52.6224043423
26 (in isoform 3)Phosphorylation-49.7924043423
27 (in isoform 3)Phosphorylation-27.8924043423
30 (in isoform 3)Phosphorylation-22.5724043423
90MethylationLVARRHYRFIHGIGR
HHHHHHHHHHCCCCC		20.2354561809
90DimethylationLVARRHYRFIHGIGR
HHHHHHHHHHCCCCC		20.23-
98PhosphorylationFIHGIGRSGDISAVQ
HHCCCCCCCCCCCCC		35.2927499020
112PhosphorylationQPKAAGSSLLNKITN
CCCCCCHHHHHHHHH		35.6424719451
118PhosphorylationSSLLNKITNSLVLDI
HHHHHHHHHHHHHHH		21.9920393185
120PhosphorylationLLNKITNSLVLDIIK
HHHHHHHHHHHHHHH		15.9420393185
144PhosphorylationCFVVPMATGMSLTLC
CEEEECCCCHHHHHH		27.45-
173UbiquitinationIWPRIDQKSCFKSMI
ECCCCCCHHHHHHHH		45.50-
203UbiquitinationDELRTDLKAVEAKVQ
CCHHHHHHHHHHHHH		53.87-
208UbiquitinationDLKAVEAKVQELGPD
HHHHHHHHHHHHCCC		30.83-
245PhosphorylationLAVICANYDIPHIVN
HHHHHHCCCCHHHHC		9.20-
255PhosphorylationPHIVNNAYGVQSSKC
HHHHCCCCCCCCHHH		21.69-
259PhosphorylationNNAYGVQSSKCMHLI
CCCCCCCCHHHHHHH		29.38-
260PhosphorylationNAYGVQSSKCMHLIQ
CCCCCCCHHHHHHHH		16.87-
284OtherAFVQSLDKNFMVPVG
HHHHHCCCCCCEEEC		58.3319608919
284N6-(pyridoxal phosphate)lysineAFVQSLDKNFMVPVG
HHHHHCCCCCCEEEC		58.33-
315PhosphorylationKMYPGRASASPSLDV
HHCCCCCCCCCCHHH		28.1128985074
317PhosphorylationYPGRASASPSLDVLI
CCCCCCCCCCHHHHH		16.7222817900
319PhosphorylationGRASASPSLDVLITL
CCCCCCCCHHHHHHH		34.4019690332
325PhosphorylationPSLDVLITLLSLGSN
CCHHHHHHHHHHCCC		19.9328985074
328PhosphorylationDVLITLLSLGSNGYK
HHHHHHHHHCCCHHH		33.5222817900
331PhosphorylationITLLSLGSNGYKKLL
HHHHHHCCCHHHHHH		32.1619690332
334PhosphorylationLSLGSNGYKKLLKER
HHHCCCHHHHHHHHH		14.8128985074
346PhosphorylationKERKEMFSYLSNQIK
HHHHHHHHHHHHHHH		24.6925884760
347PhosphorylationERKEMFSYLSNQIKK
HHHHHHHHHHHHHHH		11.6825884760
417PhosphorylationSMQTVSGYTFRGFMS
CEEEECCEEECHHHH		8.66-
466PhosphorylationKAVRKERSKESDDNY
HHHHHHHHHCCCCCC		41.7022798277
469PhosphorylationRKERSKESDDNYDKT
HHHHHHCCCCCCCCC		54.7422798277
473PhosphorylationSKESDDNYDKTEDVD
HHCCCCCCCCCCCCC		26.3028796482
476PhosphorylationSDDNYDKTEDVDIEE
CCCCCCCCCCCCHHH		34.2227251275
495PhosphorylationLDNVLLDTYQDASS-
HHHEHHHHHHHCCC-		24.0528796482
496PhosphorylationDNVLLDTYQDASS--
HHEHHHHHHHCCC--		12.2228796482
500PhosphorylationLDTYQDASS------
HHHHHHCCC------		44.8930266825
501PhosphorylationDTYQDASS-------
HHHHHCCC-------		46.0630266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPCS_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPCS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPCS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LZTL1_HUMANLZTFL1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613811Pontocerebellar hypoplasia 2D (PCH2D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPCS_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-501, AND MASSSPECTROMETRY.

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