LZTL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LZTL1_HUMAN
• UniProt AC: Q9NQ48
• Protein Name: Leucine zipper transcription factor-like protein 1
• Gene Name: LZTFL1
• Organism: Homo sapiens (Human).
• Sequence Length: 299
• Subcellular Localization: Cytoplasm .
• Protein Description: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function..
• Protein Sequence: MAELGLNEHHQNEVINYMRFARSKRGLRLKTVDSCFQDLKESRLVEDTFTIDEVSEVLNGLQAVVHSEVESELINTAYTNVLLLRQLFAQAEKWYLKLQTDISELENRELLEQVAEFEKAEITSSNKKPILDVTKPKLAPLNEGGTAELLNKEILRLQEENEKLKSRLKTIEIQATNALDEKSKLEKALQDLQLDQGNQKDFIKAQDLSNLENTVAALKSEFQKTLNDKTENQKSLEENLATAKHDLLRVQEQLHMAEKELEKKFQQTAAYRNMKEILTKKNDQIKDLRKRLAQYEPED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	LNEHHQNEVINYMRF CCHHHHHHHHHHHHH	37.90	-
13	Ubiquitination	LNEHHQNEVINYMRF CCHHHHHHHHHHHHH	37.90	24816145
23	Ubiquitination	NYMRFARSKRGLRLK HHHHHHHHCCCCCCC	24.23	-
30	Ubiquitination	SKRGLRLKTVDSCFQ HCCCCCCCCHHHHHH	39.82	24816145
30	Acetylation	SKRGLRLKTVDSCFQ HCCCCCCCCHHHHHH	39.82	26051181
31	Phosphorylation	KRGLRLKTVDSCFQD CCCCCCCCHHHHHHH	33.85	30622161
34	Phosphorylation	LRLKTVDSCFQDLKE CCCCCHHHHHHHHHH	16.70	30622161
40	Ubiquitination	DSCFQDLKESRLVED HHHHHHHHHHCCCCC	63.03	-
102	Ubiquitination	YLKLQTDISELENRE HHHHHCCHHHHHHHH	3.81	29967540
111	Ubiquitination	ELENRELLEQVAEFE HHHHHHHHHHHHHHH	3.56	29967540
115	Ubiquitination	RELLEQVAEFEKAEI HHHHHHHHHHHHHHC	18.56	29967540
119	Ubiquitination	EQVAEFEKAEITSSN HHHHHHHHHHCCCCC	57.55	29967540
124	Phosphorylation	FEKAEITSSNKKPIL HHHHHCCCCCCCCEE	37.26	28555341
124	Ubiquitination	FEKAEITSSNKKPIL HHHHHCCCCCCCCEE	37.26	29967540
125	Phosphorylation	EKAEITSSNKKPILD HHHHCCCCCCCCEEC	43.98	28555341
128	Ubiquitination	EITSSNKKPILDVTK HCCCCCCCCEECCCC	41.35	29967540
135	Ubiquitination	KPILDVTKPKLAPLN CCEECCCCCCCCCCC	39.75	29967540
148	Ubiquitination	LNEGGTAELLNKEIL CCCCCHHHHHCHHHH	54.34	24816145
152	Ubiquitination	GTAELLNKEILRLQE CHHHHHCHHHHHHHH	46.21	29967540
156	Methylation	LLNKEILRLQEENEK HHCHHHHHHHHHHHH	39.73	115482445
161	Ubiquitination	ILRLQEENEKLKSRL HHHHHHHHHHHHHHH	51.45	24816145
165	Ubiquitination	QEENEKLKSRLKTIE HHHHHHHHHHHHHHH	44.60	24816145
169	Ubiquitination	EKLKSRLKTIEIQAT HHHHHHHHHHHHHHC	46.47	29967540
174	Ubiquitination	RLKTIEIQATNALDE HHHHHHHHHCCCCCH	29.37	24816145
176	Phosphorylation	KTIEIQATNALDEKS HHHHHHHCCCCCHHH	12.49	-
202	Ubiquitination	DQGNQKDFIKAQDLS CCCCHHHHHHHHHHH	8.76	29967540
209	Phosphorylation	FIKAQDLSNLENTVA HHHHHHHHHHHHHHH	47.89	28555341
215	Ubiquitination	LSNLENTVAALKSEF HHHHHHHHHHHHHHH	4.41	29967540
219	Ubiquitination	ENTVAALKSEFQKTL HHHHHHHHHHHHHHH	43.12	29967540
224	Ubiquitination	ALKSEFQKTLNDKTE HHHHHHHHHHCCCCC	61.37	-
227	Ubiquitination	SEFQKTLNDKTENQK HHHHHHHCCCCCHHH	54.70	29967540
229	2-Hydroxyisobutyrylation	FQKTLNDKTENQKSL HHHHHCCCCCHHHHH	57.58	-
235	Phosphorylation	DKTENQKSLEENLAT CCCCHHHHHHHHHHH	31.11	27251275
240	Ubiquitination	QKSLEENLATAKHDL HHHHHHHHHHHHHHH	5.18	29967540
242	Acetylation	SLEENLATAKHDLLR HHHHHHHHHHHHHHH	39.13	-
242	Phosphorylation	SLEENLATAKHDLLR HHHHHHHHHHHHHHH	39.13	23403867
242	Acetylation	SLEENLATAKHDLLR HHHHHHHHHHHHHHH	39.13	19608861
244	Ubiquitination	EENLATAKHDLLRVQ HHHHHHHHHHHHHHH	33.04	29967540
259	Acetylation	EQLHMAEKELEKKFQ HHHHHHHHHHHHHHH	59.05	23236377
263	Acetylation	MAEKELEKKFQQTAA HHHHHHHHHHHHHHH	72.08	25953088
268	Phosphorylation	LEKKFQQTAAYRNMK HHHHHHHHHHHHHHH	11.50	28509920
271	Phosphorylation	KFQQTAAYRNMKEIL HHHHHHHHHHHHHHH	10.47	28509920
275	Malonylation	TAAYRNMKEILTKKN HHHHHHHHHHHHHCC	45.19	26320211
275	Acetylation	TAAYRNMKEILTKKN HHHHHHHHHHHHHCC	45.19	25953088
279	Phosphorylation	RNMKEILTKKNDQIK HHHHHHHHHCCHHHH	45.71	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LZTL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LZTL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LZTL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBXN7_HUMAN	UBXN7	physical	22863883
LZTL1_HUMAN	LZTFL1	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
BBS2_HUMAN	BBS2	physical	26186194
BBS4_HUMAN	BBS4	physical	26186194
TTC8_HUMAN	TTC8	physical	26186194
BBS7_HUMAN	BBS7	physical	26186194
BBS1_HUMAN	BBS1	physical	26186194
PTHB1_HUMAN	BBS9	physical	26186194
CP250_HUMAN	CEP250	physical	26186194
BBS5_HUMAN	BBS5	physical	26186194
SPD2B_HUMAN	SH3PXD2B	physical	26344197
BBS5_HUMAN	BBS5	physical	28514442
PTHB1_HUMAN	BBS9	physical	28514442
BBS4_HUMAN	BBS4	physical	28514442
TTC8_HUMAN	TTC8	physical	28514442
BBS2_HUMAN	BBS2	physical	28514442
BBS7_HUMAN	BBS7	physical	28514442
BBS1_HUMAN	BBS1	physical	28514442
CP250_HUMAN	CEP250	physical	28514442
PTHB1_HUMAN	BBS9	physical	27173435
BBS2_HUMAN	BBS2	physical	27173435
BBS7_HUMAN	BBS7	physical	27173435
BBS5_HUMAN	BBS5	physical	27173435
BBS1_HUMAN	BBS1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615994: Bardet-Biedl syndrome 17 (BBS17)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.