dbPTM

NOL12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOL12_HUMAN
UniProt AC	Q9UGY1
Protein Name	Nucleolar protein 12
Gene Name	NOL12
Organism	Homo sapiens (Human).
Sequence Length	213
Subcellular Localization	Nucleus, nucleolus.
Protein Description	May bind to 28S rRNA..
Protein Sequence	MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKHPRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	RRPRLVLSFDEEKRR CCCCEEEECCHHHHH	24.15	29449344
50	Ubiquitination	KAAIEEIKQRLKEEQ HHHHHHHHHHHHHHH	32.42	-
75	Methylation	YLKMLAEREEALEEA HHHHHHHHHHHHHHH	41.26	115483217
98	Phosphorylation	AKTESVQYDHPNHTV HEEECCCCCCCCCEE	17.67	27642862
108	Phosphorylation	PNHTVTVTTISDLDL CCCEEEEEEEECCCC	14.73	28122231
109	Phosphorylation	NHTVTVTTISDLDLS CCEEEEEEEECCCCC	17.72	28122231
111	Phosphorylation	TVTVTTISDLDLSGA EEEEEEEECCCCCCC	29.99	28122231
116	Phosphorylation	TISDLDLSGARLLGL EEECCCCCCCEECCC	30.03	29496963
124	Phosphorylation	GARLLGLTPPEGGAG CCEECCCCCCCCCCC	34.69	29255136
134	Phosphorylation	EGGAGDRSEEEASST CCCCCCCCHHHHHCC	54.84	29255136
139	Phosphorylation	DRSEEEASSTEKPTK CCCHHHHHCCCCCCC	40.86	23401153
140	Phosphorylation	RSEEEASSTEKPTKA CCHHHHHCCCCCCCC	47.86	23401153
141	Phosphorylation	SEEEASSTEKPTKAL CHHHHHCCCCCCCCC	45.60	22167270
145	Phosphorylation	ASSTEKPTKALPRKS HHCCCCCCCCCCCCC	39.76	23401153
152	Phosphorylation	TKALPRKSRDPLLSQ CCCCCCCCCCHHHHH	43.10	28555341
158	Phosphorylation	KSRDPLLSQRISSLT CCCCHHHHHHHHHHH	25.70	24719451
162	Phosphorylation	PLLSQRISSLTASLH HHHHHHHHHHHHHHH	22.83	20068231
163	Phosphorylation	LLSQRISSLTASLHA HHHHHHHHHHHHHHH	27.63	20068231
165	Phosphorylation	SQRISSLTASLHAHS HHHHHHHHHHHHHHH	19.02	28555341
167	Phosphorylation	RISSLTASLHAHSRK HHHHHHHHHHHHHHH	18.56	20068231
172	Phosphorylation	TASLHAHSRKKVKRK HHHHHHHHHHHHHHH	46.72	21712546
187	Phosphorylation	HPRRAQDSKKPPRAP CCCCCCCCCCCCCCC	30.42	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NOL12_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOL12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOL12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SODM_HUMAN	SOD2	physical	16169070
SAP18_HUMAN	SAP18	physical	16169070
A4_HUMAN	APP	physical	21832049
CEP70_HUMAN	CEP70	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
LARP7_HUMAN	LARP7	physical	26186194
CC137_HUMAN	CCDC137	physical	26186194
KNOP1_HUMAN	KNOP1	physical	26186194
RBM28_HUMAN	RBM28	physical	26186194
SF3B1_HUMAN	SF3B1	physical	26186194
RT09_HUMAN	MRPS9	physical	26186194
SPB1_HUMAN	FTSJ3	physical	26186194
RT26_HUMAN	MRPS26	physical	26186194
SF3B2_HUMAN	SF3B2	physical	26186194
DDX50_HUMAN	DDX50	physical	26186194
ZN668_HUMAN	ZNF668	physical	26186194
ZN512_HUMAN	ZNF512	physical	26186194
PTCD3_HUMAN	PTCD3	physical	26186194
DKC1_HUMAN	DKC1	physical	26186194
STAU1_HUMAN	STAU1	physical	26186194
NAT10_HUMAN	NAT10	physical	26186194
DDX27_HUMAN	DDX27	physical	26186194
RT27_HUMAN	MRPS27	physical	26186194
DDX10_HUMAN	DDX10	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
RS3A_HUMAN	RPS3A	physical	26186194
UBE2O_HUMAN	UBE2O	physical	26186194
DDX24_HUMAN	DDX24	physical	26186194
KRI1_HUMAN	KRI1	physical	26186194
RRP8_HUMAN	RRP8	physical	26186194
ZCRB1_HUMAN	ZCRB1	physical	26186194
ZCCHV_HUMAN	ZC3HAV1	physical	26186194
EBP2_HUMAN	EBNA1BP2	physical	26186194
RT10_HUMAN	MRPS10	physical	26186194
RBM19_HUMAN	RBM19	physical	26186194
SURF6_HUMAN	SURF6	physical	26186194
NPM_HUMAN	NPM1	physical	26186194
NOG1_HUMAN	GTPBP4	physical	26186194
NOP2_HUMAN	NOP2	physical	26186194
RT31_HUMAN	MRPS31	physical	26186194
RT18C_HUMAN	MRPS18C	physical	26186194
RT05_HUMAN	MRPS5	physical	26186194
MK67I_HUMAN	NIFK	physical	26186194
RBM34_HUMAN	RBM34	physical	26186194
RIOX2_HUMAN	MINA	physical	26186194
LN28B_HUMAN	LIN28B	physical	26186194
RT35_HUMAN	MRPS35	physical	26186194
RT25_HUMAN	MRPS25	physical	26186194
BRX1_HUMAN	BRIX1	physical	26186194
DDX54_HUMAN	DDX54	physical	26186194
LARP1_HUMAN	LARP1	physical	26186194
KRR1_HUMAN	KRR1	physical	26186194
RT11_HUMAN	MRPS11	physical	26186194
PUM3_HUMAN	KIAA0020	physical	26186194
PK1IP_HUMAN	PAK1IP1	physical	26186194
NOG2_HUMAN	GNL2	physical	26186194
ZBT24_HUMAN	ZBTB24	physical	26186194
ZN770_HUMAN	ZNF770	physical	26186194
DHX57_HUMAN	DHX57	physical	26186194
RS5_HUMAN	RPS5	physical	26186194
DDX31_HUMAN	DDX31	physical	26186194
RT14_HUMAN	MRPS14	physical	26186194
RT33_HUMAN	MRPS33	physical	26186194
RL14_HUMAN	RPL14	physical	26186194
NSA2_HUMAN	NSA2	physical	26186194
DDX55_HUMAN	DDX55	physical	26186194
ZN189_HUMAN	ZNF189	physical	26186194
BUD13_HUMAN	BUD13	physical	26186194
RPF1_HUMAN	RPF1	physical	26186194
UIF_HUMAN	FYTTD1	physical	26186194
NLE1_HUMAN	NLE1	physical	26186194
RT18A_HUMAN	MRPS18A	physical	26186194
SRS12_HUMAN	SRSF12	physical	26186194
ZN689_HUMAN	ZNF689	physical	26186194
NHP2_HUMAN	NHP2	physical	26186194
DDX55_HUMAN	DDX55	physical	28514442
SRS12_HUMAN	SRSF12	physical	28514442
ZN189_HUMAN	ZNF189	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
ZN689_HUMAN	ZNF689	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
PUM3_HUMAN	KIAA0020	physical	28514442
BUD13_HUMAN	BUD13	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
ZCHC7_HUMAN	ZCCHC7	physical	28514442
SPB1_HUMAN	FTSJ3	physical	28514442
RBM19_HUMAN	RBM19	physical	28514442
NOG2_HUMAN	GNL2	physical	28514442
DDX10_HUMAN	DDX10	physical	28514442
DDX27_HUMAN	DDX27	physical	28514442
STAU1_HUMAN	STAU1	physical	28514442
NAT10_HUMAN	NAT10	physical	28514442
ZN668_HUMAN	ZNF668	physical	28514442
UIF_HUMAN	FYTTD1	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
ZCCHV_HUMAN	ZC3HAV1	physical	28514442
RRP8_HUMAN	RRP8	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
RS5_HUMAN	RPS5	physical	28514442
DDX54_HUMAN	DDX54	physical	28514442
ZN512_HUMAN	ZNF512	physical	28514442
CC137_HUMAN	CCDC137	physical	28514442
DDX31_HUMAN	DDX31	physical	28514442
NLE1_HUMAN	NLE1	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
RT18C_HUMAN	MRPS18C	physical	28514442
SART3_HUMAN	SART3	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
RBM34_HUMAN	RBM34	physical	28514442
DKC1_HUMAN	DKC1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOL12_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-140 ANDTHR-141, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-124, AND MASSSPECTROMETRY.	16565220 [Abstract]