SDCG8_HUMAN - dbPTM
SDCG8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SDCG8_HUMAN
UniProt AC Q86SQ7
Protein Name Serologically defined colon cancer antigen 8
Gene Name SDCCAG8
Organism Homo sapiens (Human).
Sequence Length 713
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell junction. Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.
Isoform 2: Cytoplasm.
Protein Description Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis..
Protein Sequence MAKSPENSTLEEILGQYQRSLREHASRSIHQLTCALKEGDVTIGEDAPNLSFSTSVGNEDARTAWPELQQSHAVNQLKDLLRQQADKESEVSPSRRRKMSPLRSLEHEETNMPTMHDLVHTINDQSQYIHHLEAEVKFCKEELSGMKNKIQVVVLENEGLQQQLKSQRQEETLREQTLLDASGNMHNSWITTGEDSGVGETSKRPFSHDNADFGKAASAGEQLELEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQLLLERQSLSEEVDRLRTQLPSMPQSDC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAKSPENSTLE
----CCCCCCCCHHH		28.1023401153
8PhosphorylationMAKSPENSTLEEILG
CCCCCCCCHHHHHHH		32.4822115753
9PhosphorylationAKSPENSTLEEILGQ
CCCCCCCHHHHHHHH		50.1721082442
28PhosphorylationLREHASRSIHQLTCA
HHHHHHHHHHHHHHH		23.179610721
51PhosphorylationGEDAPNLSFSTSVGN
CCCCCCCEEECCCCC		24.6425159151
71PhosphorylationAWPELQQSHAVNQLK
HCHHHHHHHHHHHHH		10.6425159151
78UbiquitinationSHAVNQLKDLLRQQA
HHHHHHHHHHHHHHC		36.2429967540
89PhosphorylationRQQADKESEVSPSRR
HHHCCCCCCCCHHHH		49.3823403867
92PhosphorylationADKESEVSPSRRRKM
CCCCCCCCHHHHHCC		17.0723401153
94PhosphorylationKESEVSPSRRRKMSP
CCCCCCHHHHHCCCC		30.8029255136
100PhosphorylationPSRRRKMSPLRSLEH
HHHHHCCCCCHHHCC		24.6622798277
140UbiquitinationEAEVKFCKEELSGMK
HHHHHHHHHHHCCCC		58.3129967540
165UbiquitinationEGLQQQLKSQRQEET
HHHHHHHHHHHHHHH		39.9629967540
203UbiquitinationSGVGETSKRPFSHDN
CCCCCCCCCCCCCCC		72.0729967540
207PhosphorylationETSKRPFSHDNADFG
CCCCCCCCCCCCCHH		32.3928348404
215UbiquitinationHDNADFGKAASAGEQ
CCCCCHHHCCCHHHH		40.5529967540
229UbiquitinationQLELEKLKLTYEEKC
HHHHHHHCCCHHHHC		50.2629967540
231PhosphorylationELEKLKLTYEEKCEI
HHHHHCCCHHHHCCC		27.57-
232PhosphorylationLEKLKLTYEEKCEIE
HHHHCCCHHHHCCCC		32.31-
235UbiquitinationLKLTYEEKCEIEESQ
HCCCHHHHCCCCHHH		25.8129967540
261UbiquitinationQRTCEDLKEQLKHKE
HHHHHHHHHHHCCHH		56.5929967540
321PhosphorylationDLMSALVSVRSSLAD
HHHHHHHHHHHHHHH		16.8024719451
335PhosphorylationDTQQREASAYEQVKQ
HHHHHHHHHHHHHHH		26.9928796482
337PhosphorylationQQREASAYEQVKQVL
HHHHHHHHHHHHHHH		12.3728796482
341UbiquitinationASAYEQVKQVLQISE
HHHHHHHHHHHHHHH		34.0929967540
394AcetylationAIEKDMMKKEITKER
HHHHHHHHHHHHHHH		40.397378639
395MethylationIEKDMMKKEITKERE
HHHHHHHHHHHHHHH		36.1323644510
395"N6,N6-dimethyllysine"IEKDMMKKEITKERE
HHHHHHHHHHHHHHH		36.13-
399MethylationMMKKEITKEREYMGS
HHHHHHHHHHHHHHH		61.5123644510
399"N6,N6-dimethyllysine"MMKKEITKEREYMGS
HHHHHHHHHHHHHHH		61.51-
429UbiquitinationVEKVTKEKISAINQL
HHHHHHHHHHHHHHH		43.4429967540
513UbiquitinationHLEQEQQKAALAREE
HHHHHHHHHHHHHHH		35.0129967540
544PhosphorylationLTRQEKDSIQQSFSK
HCHHHHHHHHHHCCH		33.11-
548PhosphorylationEKDSIQQSFSKEAKA
HHHHHHHHCCHHHHH		18.3424719451
550PhosphorylationDSIQQSFSKEAKAQA
HHHHHHCCHHHHHHH		34.53-
568PhosphorylationQQREQELTQKIQQME
HHHHHHHHHHHHHHH		27.36-
586PhosphorylationDKTENEQYLLLTSQN
CCCCCCCEEEEECCC		7.9827642862
616UbiquitinationKLEQISQKTRSEIAQ
HHHHHHHHHHHHHHH		38.8329967540
625PhosphorylationRSEIAQLSQEKRYTY
HHHHHHHHHHHCHHH		24.9827966365
630PhosphorylationQLSQEKRYTYDKLGK
HHHHHHCHHHHHHHH		22.25-
682PhosphorylationQQLVQLLSKQNQLLL
HHHHHHHHHHHHHHH		40.5624719451
711PhosphorylationQLPSMPQSDC-----
HCCCCCCCCC-----		34.7727251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SDCG8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SDCG8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SDCG8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
OFD1_HUMANOFD1physical
27173435
UBE2N_HUMANUBE2Nphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613615Senior-Loken syndrome 7 (SLSN7)
615993Bardet-Biedl syndrome 16 (BBS16)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SDCG8_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory