FADS1_HUMAN - dbPTM
FADS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FADS1_HUMAN
UniProt AC O60427
Protein Name Fatty acid desaturase 1
Gene Name FADS1
Organism Homo sapiens (Human).
Sequence Length 444
Subcellular Localization Isoform 1: Endoplasmic reticulum membrane
Multi-pass membrane protein . Mitochondrion .
Isoform 2: Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively..
Protein Sequence MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQLQATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLLSAFADIIHSLKESGQLWLDAYLHQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MAPDPVAA
-------CCCCHHHH		12.6225732826
19PhosphorylationAQGPTPRYFTWDEVA
HCCCCCCCCCHHHHH		13.4328796482
41UbiquitinationRWLVIDRKVYNISEF
EEEEEEEEEEEHHHH		45.3721906983
78UbiquitinationFVAFHINKGLVKKYM
EEEEEECHHHHHHHH		53.6821890473
78UbiquitinationFVAFHINKGLVKKYM
EEEEEECHHHHHHHH		53.68-
83UbiquitinationINKGLVKKYMNSLLI
ECHHHHHHHHHHHHH		42.1021890473
83UbiquitinationINKGLVKKYMNSLLI
ECHHHHHHHHHHHHH		42.10-
98UbiquitinationGELSPEQPSFEPTKN
CCCCCCCCCCCCCCC		39.05-
104UbiquitinationQPSFEPTKNKELTDE
CCCCCCCCCHHHCHH		76.4021906983
106UbiquitinationSFEPTKNKELTDEFR
CCCCCCCHHHCHHHH		56.5121906983
135UbiquitinationNHVFFLLYLLHILLL
HHHHHHHHHHHHHHH		14.9021890473
139UbiquitinationFLLYLLHILLLDGAA
HHHHHHHHHHHCHHH		2.67-
140UbiquitinationLLYLLHILLLDGAAW
HHHHHHHHHHCHHHH		2.4321890473
161UbiquitinationGTSFLPFLLCAVLLS
CCCHHHHHHHHHHHH		3.47-
163UbiquitinationSFLPFLLCAVLLSAV
CHHHHHHHHHHHHHH		2.4021890473
251UbiquitinationILSVELGKQKKKYMP
HHHHHCCCCCCCCCC		72.1321906983
253UbiquitinationSVELGKQKKKYMPYN
HHHCCCCCCCCCCCC		55.51-
285UbiquitinationYFQWYIFYFVIQRKK
HHHHHHHHHHHHCCC		6.33-
308UbiquitinationTFYVRFFLTYVPLLG
HHHHHHHHHHHHHHC		2.88-
310UbiquitinationYVRFFLTYVPLLGLK
HHHHHHHHHHHHCHH		11.39-
312UbiquitinationRFFLTYVPLLGLKAF
HHHHHHHHHHCHHHH		16.08-
398UbiquitinationMPRHNYHKVAPLVQS
CCCCCHHHHHHHHHH		29.7221906983
416PhosphorylationKHGIEYQSKPLLSAF
HCCCCCCCHHHHHHH		35.0324719451
417UbiquitinationHGIEYQSKPLLSAFA
CCCCCCCHHHHHHHH		24.942190698
455Ubiquitination------------------
------------------		-
466Ubiquitination-----------------------------
-----------------------------		-
474Ubiquitination-------------------------------------
-------------------------------------		-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FADS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FADS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FADS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PAAF1_HUMANPAAF1physical
17353931
DHCR7_HUMANDHCR7physical
17353931
RN181_HUMANRNF181physical
28514442
UQCC1_HUMANUQCC1physical
28514442
ASPC1_HUMANASPSCR1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00132Alpha-Linolenic Acid
DB00159Icosapent
Regulatory Network of FADS1_HUMAN

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Related Literatures of Post-Translational Modification

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