KCJ11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCJ11_HUMAN
• UniProt AC: Q14654
• Protein Name: ATP-sensitive inward rectifier potassium channel 11
• Gene Name: KCNJ11
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation..
• Protein Sequence: MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	EDPAEPRYRARQRRA CCCCCHHHHHHHHHH		18083107
93	Phosphorylation	FAMAWWLIAFAHGDL HHHHHHHHHHHHCCC		-
137	Phosphorylation	TIGFGGRMVTEECPL EEECCCEECCCCCCH		-
180	Phosphorylation	QAHRRAETLIFSKHA HHHHHHHHHHCCCHH		-
184	Phosphorylation	RAETLIFSKHAVIAL HHHHHHCCCHHHHHH		24719451
208	Phosphorylation	RVGDLRKSMIISATI EECCHHHHHEEEEEE		-
224	Phosphorylation	MQVVRKTTSPEGEVV EEEEECCCCCCCCEE		-
285	Phosphorylation	HQDLEIIVILEGVVE CCCCEEEEEEECEEC		-
298	Phosphorylation	VETTGITTQARTSYL ECCCCCCCCCCHHHH		18280666
332	Ubiquitination	RYSVDYSKFGNTIKV CEEEEHHHCCCEEEC		21890473
332	Ubiquitination	RYSVDYSKFGNTIKV CEEEEHHHCCCEEEC		21890473
332	Ubiquitination	RYSVDYSKFGNTIKV CEEEEHHHCCCEEEC		21890473
341	Phosphorylation	GNTIKVPTPLCTARQ CCEEECCCCCCCCHH		18280666
372	Phosphorylation	RGPLRKRSVPMAKAK CCCCHHCCCCCCCCC		24719451
385	Phosphorylation	AKPKFSISPDSLS-- CCCCCCCCCCCCC--		7502040
388	Phosphorylation	KFSISPDSLS----- CCCCCCCCCC-----		28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
224	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
224	T	Phosphorylation	Kinase	CAMK2D	Q13557	PSP
341	T	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
372	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
385	S	Phosphorylation	Kinase	MAPK1	P28482	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCJ11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCJ11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNJ8_HUMAN	KCNJ8	physical	11136227
1433B_HUMAN	YWHAB	physical	23772394
MINY2_HUMAN	FAM63B	physical	26186194
MINY2_HUMAN	FAM63B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 601820: Familial hyperinsulinemic hypoglycemia 2 (HHF2)
• 606176: Diabetes mellitus, permanent neonatal (PNDM)
• 610582: Transient neonatal diabetes mellitus 3 (TNDM3)
• : Note=Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2.
• 616329:
• Kegg Drug
• DrugBank
• DB01119: Diazoxide
• DB00222: Glimepiride
• DB01016: Glyburide
• DB00308: Ibutilide
• DB00922: Levosimendan
• DB01154: Thiamylal
• DB00661: Verapamil
• DB01392: Yohimbine