| UniProt ID | MINY2_HUMAN | |
|---|---|---|
| UniProt AC | Q8NBR6 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase MINDY-2 {ECO:0000303|PubMed:27292798} | |
| Gene Name | MINDY2 {ECO:0000312|HGNC:HGNC:26954} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 621 | |
| Subcellular Localization | ||
| Protein Description | Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. [PubMed: 27292798 Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63'] | |
| Protein Sequence | MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVWAAETSGGNGLGAAAARRSLPDSASPAGSPEVPGPCSSSAGLDLKDSGLESPAAAEAPLRGQYKVTASPETAVAGVGHELGTAGDAGARPDLAGTCQAELTAAGSEEPSSAGGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLCKEEEGEETAQVLAASKERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFSTMTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLRPPSDPETVYKGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQEQAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | PGVWAAETSGGNGLG CCEEEEECCCCCCCH | 26074081 | ||
| 49 | Phosphorylation | GVWAAETSGGNGLGA CEEEEECCCCCCCHH | 26074081 | ||
| 62 | Phosphorylation | GAAAARRSLPDSASP HHHHHHHCCCCCCCC | 26657352 | ||
| 66 | Phosphorylation | ARRSLPDSASPAGSP HHHCCCCCCCCCCCC | 28450419 | ||
| 68 | Phosphorylation | RSLPDSASPAGSPEV HCCCCCCCCCCCCCC | 26657352 | ||
| 72 | Phosphorylation | DSASPAGSPEVPGPC CCCCCCCCCCCCCCC | 28450419 | ||
| 80 | Phosphorylation | PEVPGPCSSSAGLDL CCCCCCCCCCCCCCC | 27080861 | ||
| 81 | Phosphorylation | EVPGPCSSSAGLDLK CCCCCCCCCCCCCCH | 27080861 | ||
| 82 | Phosphorylation | VPGPCSSSAGLDLKD CCCCCCCCCCCCCHH | 27080861 | ||
| 90 | Phosphorylation | AGLDLKDSGLESPAA CCCCCHHCCCCCCCH | 29396449 | ||
| 94 | Phosphorylation | LKDSGLESPAAAEAP CHHCCCCCCCHHCCC | 29255136 | ||
| 233 | Phosphorylation | TAQVLAASKERFPGQ HHHHHHHHHHCCCCC | 28270605 | ||
| 234 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 234 | Ubiquitination | AQVLAASKERFPGQS HHHHHHHHHCCCCCC | 21906983 | ||
| 234 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 234 | Ubiquitination | AQVLAASKERFPGQS HHHHHHHHHCCCCCC | 21890473 | ||
| 298 | Phosphorylation | TAEQLMEYLGDYMLD CHHHHHHHHCHHHHC | - | ||
| 307 | Ubiquitination | GDYMLDAKPKEISEI CHHHHCCCHHHCHHH | 22817900 | ||
| 309 | Ubiquitination | YMLDAKPKEISEIQR HHHCCCHHHCHHHHH | 27667366 | ||
| 309 | Ubiquitination | YMLDAKPKEISEIQR HHHCCCHHHCHHHHH | 21890473 | ||
| 309 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 309 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 393 | Ubiquitination | SYNQLVEKIISCKQS CHHHHHHHHHHCCCC | 29967540 | ||
| 454 | Ubiquitination | NHFSTMTKYKGQLYL CCCCEEEEECCEEEE | - | ||
| 465 | Ubiquitination | QLYLLVTDQGFLTEE EEEEEEECCCCCCCE | 22817900 | ||
| 466 | Ubiquitination | LYLLVTDQGFLTEEK EEEEEECCCCCCCEE | 22817900 | ||
| 483 | Ubiquitination | WESLHNVDGDGNFCD HHHHCCCCCCCCCCC | 22817900 | ||
| 484 | Ubiquitination | ESLHNVDGDGNFCDS HHHCCCCCCCCCCCC | 22817900 | ||
| 491 | Phosphorylation | GDGNFCDSEFHLRPP CCCCCCCCCEEECCC | 26471730 | ||
| 499 | Phosphorylation | EFHLRPPSDPETVYK CEEECCCCCHHHHHC | 26471730 | ||
| 503 | Phosphorylation | RPPSDPETVYKGQQD CCCCCHHHHHCCCHH | 26471730 | ||
| 505 | Phosphorylation | PSDPETVYKGQQDQI CCCHHHHHCCCHHHC | 26471730 | ||
| 513 | Ubiquitination | KGQQDQIDQDYLMAL CCCHHHCCHHHHHHH | 22817900 | ||
| 514 | Ubiquitination | GQQDQIDQDYLMALS CCHHHCCHHHHHHHH | 22817900 | ||
| 531 | Ubiquitination | QEQQSQEINWEQIPE HHHHHCCCCHHHCCC | 22817900 | ||
| 532 | Ubiquitination | EQQSQEINWEQIPEG HHHHCCCCHHHCCCC | 22817900 | ||
| 547 | Ubiquitination | ISDLELAKKLQEEED CCHHHHHHHHHHHHH | 22817900 | ||
| 548 | Ubiquitination | SDLELAKKLQEEEDR CHHHHHHHHHHHHHH | 27667366 | ||
| 548 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 548 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 565 | Ubiquitination | SQYYQEQEQAAAAAA HHHHHHHHHHHHHHH | 22817900 | ||
| 566 | Ubiquitination | QYYQEQEQAAAAAAA HHHHHHHHHHHHHHH | 22817900 | ||
| 575 | Phosphorylation | AAAAAAASTQAQQGQ HHHHHHHHHHHHCCC | 28450419 | ||
| 576 | Phosphorylation | AAAAAASTQAQQGQP HHHHHHHHHHHCCCC | 28450419 | ||
| 587 | Phosphorylation | QGQPAQASPSSGRQS CCCCCCCCCCCCCCC | 21955146 | ||
| 589 | Phosphorylation | QPAQASPSSGRQSGN CCCCCCCCCCCCCCC | 28450419 | ||
| 590 | Phosphorylation | PAQASPSSGRQSGNS CCCCCCCCCCCCCCC | 28450419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MINY2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MINY2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MINY2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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