| UniProt ID | CP2J2_HUMAN | |
|---|---|---|
| UniProt AC | P51589 | |
| Protein Name | Cytochrome P450 2J2 | |
| Gene Name | CYP2J2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 502 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Peripheral membrane protein. Microsome membrane Peripheral membrane protein. |
|
| Protein Description | This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.. | |
| Protein Sequence | MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 20 | Phosphorylation | WAVVHPRTLLLGTVA HHHHCHHHHHHHHHH | 26.63 | - | |
| 25 | Phosphorylation | PRTLLLGTVAFLLAA HHHHHHHHHHHHHHH | 14.50 | - | |
| 141 | Phosphorylation | WKEQRRFTLTALRNF HHHHHHHHHHHHHHC | 22.76 | 28857561 | |
| 143 | Phosphorylation | EQRRFTLTALRNFGL HHHHHHHHHHHHCCC | 22.16 | 23312004 | |
| 259 | Phosphorylation | KKLKLFVSHMIDKHR HHHHHHHHHHHHHHC | 10.45 | - | |
| 274 | Phosphorylation | KDWNPAETRDFIDAY CCCCHHHHHHHHHHH | 37.33 | 20058876 | |
| 281 | Phosphorylation | TRDFIDAYLKEMSKH HHHHHHHHHHHHHHH | 17.98 | 20058876 | |
| 442 | Phosphorylation | REAFMPFSIGKRACL EEECCCCCHHHCHHH | 25.26 | 28857561 | |
| 490 | Phosphorylation | FRMGITISPVSHRLC EECCEEEECCCHHCC | 15.59 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CP2J2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CP2J2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CP2J2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ELOC_HUMAN | TCEB1 | physical | 21988832 | |
| ZBT25_HUMAN | ZBTB25 | physical | 21988832 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| D00425 | Nabumetone (JP16/USP/INN); Relafen (TN) |
| D07086 | Rivaroxaban (JAN/USAN/INN); Xarelto (TN) |
| DrugBank | |
| DB06605 | Apixaban |
| DB00637 | Astemizole |
| DB00169 | Cholecalciferol |
| DB08918 | Levomilnacipran |
| DB00179 | Masoprocol |
| DB06228 | Rivaroxaban |
loading...
