| UniProt ID | ALG11_HUMAN | |
|---|---|---|
| UniProt AC | Q2TAA5 | |
| Protein Name | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase | |
| Gene Name | ALG11 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 492 | |
| Subcellular Localization |
Endoplasmic reticulum . Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.. | |
| Protein Sequence | MAAGERSWCLCKLLRFFYSLFFPGLIVCGTLCVCLVIVLWGIRLLLQRKKKLVSTSKNGKNQMVIAFFHPYCNAGGGGERVLWCALRALQKKYPEAVYVVYTGDVNVNGQQILEGAFRRFNIRLIHPVQFVFLRKRYLVEDSLYPHFTLLGQSLGSIFLGWEALMQCVPDVYIDSMGYAFTLPLFKYIGGCQVGSYVHYPTISTDMLSVVKNQNIGFNNAAFITRNPFLSKVKLIYYYLFAFIYGLVGSCSDVVMVNSSWTLNHILSLWKVGNCTNIVYPPCDVQTFLDIPLHEKKMTPGHLLVSVGQFRPEKNHPLQIRAFAKLLNKKMVESPPSLKLVLIGGCRNKDDELRVNQLRRLSEDLGVQEYVEFKINIPFDELKNYLSEATIGLHTMWNEHFGIGVVECMAAGTIILAHNSGGPKLDIVVPHEGDITGFLAESEEDYAETIAHILSMSAEKRLQIRKSARASVSRFSDQEFEVTFLSSVEKLFK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Ubiquitination | KKLVSTSKNGKNQMV HHHHEECCCCCCCEE | 70.57 | 27667366 | |
| 187 | Phosphorylation | FTLPLFKYIGGCQVG CCCCHHHHCCCCEEC | 9.47 | 24043423 | |
| 195 | Phosphorylation | IGGCQVGSYVHYPTI CCCCEECCEEECCCC | 25.73 | 24043423 | |
| 196 | Phosphorylation | GGCQVGSYVHYPTIS CCCEECCEEECCCCC | 5.82 | 24043423 | |
| 199 | Phosphorylation | QVGSYVHYPTISTDM EECCEEECCCCCCCH | 7.63 | 24043423 | |
| 201 | Phosphorylation | GSYVHYPTISTDMLS CCEEECCCCCCCHHH | 22.01 | 24043423 | |
| 203 | Phosphorylation | YVHYPTISTDMLSVV EEECCCCCCCHHHHH | 22.34 | 24043423 | |
| 204 | Phosphorylation | VHYPTISTDMLSVVK EECCCCCCCHHHHHH | 22.90 | 24043423 | |
| 208 | Phosphorylation | TISTDMLSVVKNQNI CCCCCHHHHHHCCCC | 20.44 | 50564633 | |
| 257 | N-linked_Glycosylation | CSDVVMVNSSWTLNH CCCEEEECCCCHHHH | 16.54 | UniProtKB CARBOHYD | |
| 273 | N-linked_Glycosylation | LSLWKVGNCTNIVYP HHHHCCCCCEECCCC | 32.21 | UniProtKB CARBOHYD | |
| 295 | Ubiquitination | LDIPLHEKKMTPGHL ECCCCCCCCCCCCEE | 36.78 | 32015554 | |
| 296 | Ubiquitination | DIPLHEKKMTPGHLL CCCCCCCCCCCCEEE | 45.05 | - | |
| 324 | Ubiquitination | LQIRAFAKLLNKKMV HHHHHHHHHHCCHHC | 47.24 | 29967540 | |
| 329 | Ubiquitination | FAKLLNKKMVESPPS HHHHHCCHHCCCCCC | 47.29 | - | |
| 333 | Phosphorylation | LNKKMVESPPSLKLV HCCHHCCCCCCCEEE | 30.60 | 25262027 | |
| 336 | Phosphorylation | KMVESPPSLKLVLIG HHCCCCCCCEEEEEE | 41.33 | 25262027 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ALG11_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ALG11_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ALG11_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ALG11_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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