| UniProt ID | XXLT1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NBI6 | |
| Protein Name | Xyloside xylosyltransferase 1 {ECO:0000303|PubMed:22117070} | |
| Gene Name | XXYLT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 393 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein . |
|
| Protein Description | Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. [PubMed: 22117070] | |
| Protein Sequence | MGLLRGGLPCARAMARLGAVRSHYCALLLAAALAVCAFYYLGSGRETFSSATKRLKEARAGAPAAPSPPALELARGSVAPAPGAKAKSLEGGGAGPVDYHLLMMFTKAEHNAALQAKARVALRSLLRLAKFEAHEVLNLHFVSEEASREVAKGLLRELLPPAAGFKCKVIFHDVAVLTDKLFPIVEAMQKHFSAGLGTYYSDSIFFLSVAMHQIMPKEILQIIQLDLDLKFKTNIRELFEEFDSFLPGAIIGIAREMQPVYRHTFWQFRHENPQTRVGGPPPEGLPGFNSGVMLLNLEAMRQSPLYSRLLEPAQVQQLADKYHFRGHLGDQDFFTMIGMEHPKLFHVLDCTWNRQLCTWWRDHGYSDVFEAYFRCEGHVKIYHGNCNTPIPED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Phosphorylation | ARLGAVRSHYCALLL HHHHHHHHHHHHHHH | 16.53 | 24719451 | |
| 24 | Phosphorylation | LGAVRSHYCALLLAA HHHHHHHHHHHHHHH | 4.81 | 24719451 | |
| 39 | Phosphorylation | ALAVCAFYYLGSGRE HHHHHHHHHHHCCHH | 4.54 | 24719451 | |
| 40 | Phosphorylation | LAVCAFYYLGSGRET HHHHHHHHHHCCHHH | 9.72 | - | |
| 67 | O-linked_Glycosylation | AGAPAAPSPPALELA CCCCCCCCCCHHHHH | 38.50 | 27114449 | |
| 67 | Phosphorylation | AGAPAAPSPPALELA CCCCCCCCCCHHHHH | 38.50 | 28176443 | |
| 77 | O-linked_Glycosylation | ALELARGSVAPAPGA HHHHHCCCCCCCCCC | 15.00 | 55832947 | |
| 77 | Phosphorylation | ALELARGSVAPAPGA HHHHHCCCCCCCCCC | 15.00 | 28176443 | |
| 85 | Ubiquitination | VAPAPGAKAKSLEGG CCCCCCCCCCCCCCC | 63.36 | - | |
| 88 | Phosphorylation | APGAKAKSLEGGGAG CCCCCCCCCCCCCCC | 36.19 | 28348404 | |
| 115 (in isoform 3) | Ubiquitination | - | 35.77 | 21890473 | |
| 117 | Ubiquitination | HNAALQAKARVALRS HHHHHHHHHHHHHHH | 24.62 | - | |
| 117 | 2-Hydroxyisobutyrylation | HNAALQAKARVALRS HHHHHHHHHHHHHHH | 24.62 | - | |
| 118 (in isoform 2) | Ubiquitination | - | 17.75 | 21890473 | |
| 307 | Phosphorylation | MRQSPLYSRLLEPAQ HHCCCHHHHHCCHHH | 24.92 | 24719451 | |
| 321 (in isoform 1) | Ubiquitination | - | 34.71 | 21890473 | |
| 321 | Ubiquitination | QVQQLADKYHFRGHL HHHHHHHHHCCCCCC | 34.71 | 21890473 | |
| 322 | Phosphorylation | VQQLADKYHFRGHLG HHHHHHHHCCCCCCC | 13.51 | 27251275 | |
| 335 | Phosphorylation | LGDQDFFTMIGMEHP CCCCCHHHHHCCCCC | 14.10 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of XXLT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of XXLT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of XXLT1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of XXLT1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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