S27A6_HUMAN - dbPTM
S27A6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID S27A6_HUMAN
UniProt AC Q9Y2P4
Protein Name Long-chain fatty acid transport protein 6
Gene Name SLC27A6
Organism Homo sapiens (Human).
Sequence Length 619
Subcellular Localization Membrane
Multi-pass membrane protein . Cell membrane, sarcolemma. In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36..
Protein Description Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart..
Protein Sequence MLLSWLTVLGAGMVVLHFLQKLLFPYFWDDFWFVLKVVLIIIRLKKYEKRGELVTVLDKFLSHAKRQPRKPFIIYEGDIYTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAVLWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLLSWLTVLGA
----CCHHHHHHHHH		18.9724043423
7Phosphorylation-MLLSWLTVLGAGMV
-CCHHHHHHHHHHHH		13.8724043423
47PhosphorylationIIIRLKKYEKRGELV
HHHHHHHHHHHCCHH		25.70-
55PhosphorylationEKRGELVTVLDKFLS
HHHCCHHHHHHHHHH		28.16-
80PhosphorylationIIYEGDIYTYQDVDK
EEEECCEEEECCCCC		12.25-
183TrimethylationNISVWGMKDSVPQGV
CEEEECCCCCCCCCE		42.80-
183MethylationNISVWGMKDSVPQGV
CEEEECCCCCCCCCE		42.8023644510
185PhosphorylationSVWGMKDSVPQGVIS
EEECCCCCCCCCEEE		30.1329083192
192PhosphorylationSVPQGVISLKEKLST
CCCCCEEEHHHHHCC		30.8624719451
196UbiquitinationGVISLKEKLSTSPDE
CEEEHHHHHCCCCCC		46.2621906983
213PhosphorylationPRSHHVVSLLKSTCL
CCHHHHHHHHHHHEE		27.2224719451
217PhosphorylationHVVSLLKSTCLYIFT
HHHHHHHHHEEEEEC		25.0727251275
218PhosphorylationVVSLLKSTCLYIFTS
HHHHHHHHEEEEECC		12.6327251275
221PhosphorylationLLKSTCLYIFTSGTT
HHHHHEEEEECCCCC		8.9927251275
224PhosphorylationSTCLYIFTSGTTGLP
HHEEEEECCCCCCCC		19.3827251275
225PhosphorylationTCLYIFTSGTTGLPK
HEEEEECCCCCCCCH		24.3227251275
227PhosphorylationLYIFTSGTTGLPKAA
EEEECCCCCCCCHHH		19.9127251275
228PhosphorylationYIFTSGTTGLPKAAV
EEECCCCCCCCHHHH		40.0027251275
383PhosphorylationRIGAIGRTNLFYKLL
CCCCCCCHHHHHHHH		30.9430266825
387PhosphorylationIGRTNLFYKLLSTFD
CCCHHHHHHHHHHHC		12.1430266825
426PhosphorylationGEPGLLISRVNAKNP
CCCCEEEEEECCCCC		30.10-
586AcetylationEDGFNPLKISEPLYF
HCCCCCCCCCCCEEC		45.507366865
588PhosphorylationGFNPLKISEPLYFMD
CCCCCCCCCCEECCC		31.4129083192
592PhosphorylationLKISEPLYFMDNLKK
CCCCCCEECCCCCCC		13.9429083192
600PhosphorylationFMDNLKKSYVLLTRE
CCCCCCCCEEEEHHH		20.9129083192
601PhosphorylationMDNLKKSYVLLTREL
CCCCCCCEEEEHHHH		12.1929083192
605PhosphorylationKKSYVLLTRELYDQI
CCCEEEEHHHHHHHH		20.2429083192
609PhosphorylationVLLTRELYDQIMLGE
EEEHHHHHHHHHHCC		10.88-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of S27A6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of S27A6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of S27A6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CUTC_HUMANCUTCphysical
16169070
TR10C_HUMANTNFRSF10Cphysical
16169070
VIME_HUMANVIMphysical
16169070
RACK1_HUMANGNB2L1physical
16169070
CHD3_HUMANCHD3physical
16169070
WDR41_HUMANWDR41physical
28514442
TTC4_HUMANTTC4physical
28514442
LRC15_HUMANLRRC15physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of S27A6_HUMAN

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Related Literatures of Post-Translational Modification

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