TR10C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TR10C_HUMAN
• UniProt AC: O14798
• Protein Name: Tumor necrosis factor receptor superfamily member 10C
• Gene Name: TNFRSF10C
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor.
• Protein Description: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand..
• Protein Sequence: MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	QEEVPQQTVAPQQQR HHCCCCCCCCHHHHC	17.25	24043423
38	O-linked_Glycosylation	QEEVPQQTVAPQQQR HHCCCCCCCCHHHHC	17.25	OGP
77	N-linked_Glycosylation	TEGVDYTNASNNEPS CCCCCCCCCCCCCCC	34.83	UniProtKB CARBOHYD
99	Phosphorylation	KSDQKHKSSCTMTRD CCCCCCCCCCCCCCC	30.30	24043423
100	Phosphorylation	SDQKHKSSCTMTRDT CCCCCCCCCCCCCCC	20.57	24043423
102	Phosphorylation	QKHKSSCTMTRDTVC CCCCCCCCCCCCCEE	24.43	24043423
104	Phosphorylation	HKSSCTMTRDTVCQC CCCCCCCCCCCEEEE	13.77	24043423
140	N-linked_Glycosylation	SGEVQVSNCTSWDDI CCCEEEECCCCHHHC	33.94	UniProtKB CARBOHYD
156	N-linked_Glycosylation	CVEEFGANATVETPA CHHHHCCCCEEECCC	36.20	UniProtKB CARBOHYD
182	Phosphorylation	PAPAAEETMNTSPGT CCCCHHHHHCCCCCC	13.76	22468782
185	Phosphorylation	AAEETMNTSPGTPAP CHHHHHCCCCCCCCC	26.02	22468782
204	Phosphorylation	TMTTSPGTPAPAAEE CCCCCCCCCCCCCHH	21.47	22468782
236	GPI-anchor	ITSPGTPASSHYLSC EECCCCCCHHHHHHH	24.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TR10C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TR10C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TR10C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOA1_HUMAN	APOA1	physical	16169070
RFLB_HUMAN	FAM101B	physical	16169070
ZHX1_HUMAN	ZHX1	physical	16169070

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.