RFLB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFLB_HUMAN
• UniProt AC: Q8N5W9
• Protein Name: Refilin-B
• Gene Name: RFLNB {ECO:0000312|HGNC:HGNC:28705}
• Organism: Homo sapiens (Human).
• Sequence Length: 214
• Subcellular Localization: Cytoplasm, cytoskeleton . Colocalizes with FLNA along actin bundle-like structures.
• Protein Description: Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements..
• Protein Sequence: MVGRLSLQDVPELVDAKKKGDGVLDSPDSGLPPSPSPSHWGLAAGGGGGERAAAPGTLEPDAAAATPAAPSPASLPLAPGCALRLCPLSFGEGVEFDPLPPKEVRYTSLVKYDSERHFIDDVQLPLGLAVASCSQTVTCVPNGTWRNYKAEVRFEPRHRPTRFLSTTIVYPKYPKAVYTTTLDYNCRKTLRRFLSSVELEAAELPGSDDLSDEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVGRLSLQDVPEL --CCCCCCCCHHHHH		30266825
26	Phosphorylation	KGDGVLDSPDSGLPP CCCCCCCCCCCCCCC		21712546
29	Phosphorylation	GVLDSPDSGLPPSPS CCCCCCCCCCCCCCC		23401153
34	Phosphorylation	PDSGLPPSPSPSHWG CCCCCCCCCCCCCCC		23401153
36	Phosphorylation	SGLPPSPSPSHWGLA CCCCCCCCCCCCCCC		25850435
38	Phosphorylation	LPPSPSPSHWGLAAG CCCCCCCCCCCCCCC		25850435
57	Phosphorylation	ERAAAPGTLEPDAAA CCCCCCCCCCCCHHH		27251275
66	Phosphorylation	EPDAAAATPAAPSPA CCCHHHCCCCCCCCC		29255136
71	Phosphorylation	AATPAAPSPASLPLA HCCCCCCCCCCCCCC		29255136
74	Phosphorylation	PAAPSPASLPLAPGC CCCCCCCCCCCCCCE		29255136
106	Phosphorylation	LPPKEVRYTSLVKYD CCCCCCEEEEEEEEC		25690035
112	Phosphorylation	RYTSLVKYDSERHFI EEEEEEEECCCCCCC		25690035
114	Phosphorylation	TSLVKYDSERHFIDD EEEEEECCCCCCCCC		25690035
170	Phosphorylation	FLSTTIVYPKYPKAV EEEEEEECCCCCCCE		-
172	Acetylation	STTIVYPKYPKAVYT EEEEECCCCCCCEEE		8082921
173	Phosphorylation	TTIVYPKYPKAVYTT EEEECCCCCCCEEEE		22461510
178	Phosphorylation	PKYPKAVYTTTLDYN CCCCCCEEEECCCHH		24043423
179	Phosphorylation	KYPKAVYTTTLDYNC CCCCCEEEECCCHHH		24043423
180	Phosphorylation	YPKAVYTTTLDYNCR CCCCEEEECCCHHHH		24043423
181	Phosphorylation	PKAVYTTTLDYNCRK CCCEEEECCCHHHHH		24043423
184	Phosphorylation	VYTTTLDYNCRKTLR EEEECCCHHHHHHHH		24043423
195	Phosphorylation	KTLRRFLSSVELEAA HHHHHHHHHCHHHHC		20736484
196	Phosphorylation	TLRRFLSSVELEAAE HHHHHHHHCHHHHCC		20058876
207	Phosphorylation	EAAELPGSDDLSDEC HHCCCCCCCCCCCCC		29691806
211	Phosphorylation	LPGSDDLSDEC---- CCCCCCCCCCC----		29691806

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFLB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFLB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFLB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT5_HUMAN	KAT5	physical	16169070
ZBT16_HUMAN	ZBTB16	physical	16169070

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.