WDR41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR41_HUMAN
• UniProt AC: Q9HAD4
• Protein Name: WD repeat-containing protein 41 {ECO:0000305}
• Gene Name: WDR41 {ECO:0000312|HGNC:HGNC:25601}
• Organism: Homo sapiens (Human).
• Sequence Length: 459
• Subcellular Localization: Cytoplasm .
• Protein Description: Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. [PubMed: 27193190]
• Protein Sequence: MLRWLIGGGREPQGLAEKSPLQTIGEEQTQNPYTELLVLKAHHDIVRFLVQLDDYRFASAGDDGIVVVWNAQTGEKLLELNGHTQKITAIITFPSLESCEEKNQLILTASADRTVIVWDGDTTRQVQRISCFQSTVKCLTVLQRLDVWLSGGNDLCVWNRKLDLLCKTSHLSDTGISALVEIPKNCVVAAVGKELIIFRLVAPTEGSLEWDILEVKRLLDHQDNILSLINVNDLSFVTGSHVGELIIWDALDWTMQAYERNFWDPSPQLDTQQEIKLCQKSNDISIHHFTCDEENVFAAVGRGLYVYSLQMKRVIACQKTAHDSNVLHVARLPNRQLISCSEDGSVRIWELREKQQLAAEPVPTGFFNMWGFGRVSKQASQPVKKQQENATSCSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILWKNGERESGLRSLRLFQKLEENGDLYLAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	EPQGLAEKSPLQTIG CCCCCCCCCCCCCCC	52.33	21906983
19	Phosphorylation	PQGLAEKSPLQTIGE CCCCCCCCCCCCCCC	23.50	22199227
40	Ubiquitination	YTELLVLKAHHDIVR CCCHHHHHHHHHHHH	37.89	-
106	Ubiquitination	CEEKNQLILTASADR HHHHCCEEEEEECCC	2.01	-
129	Ubiquitination	TTRQVQRISCFQSTV CHHHHHHHHHHHHHH	2.05	-
137	Ubiquitination	SCFQSTVKCLTVLQR HHHHHHHHHHHHHHH	24.50	-
138	Ubiquitination	CFQSTVKCLTVLQRL HHHHHHHHHHHHHHH	3.15	-
161	Ubiquitination	DLCVWNRKLDLLCKT CEEEEHHHHHHHEEC	43.04	-
161	Ubiquitination	DLCVWNRKLDLLCKT CEEEEHHHHHHHEEC	43.04	-
167	Ubiquitination	RKLDLLCKTSHLSDT HHHHHHEECCCCCCC	53.70	-
184	Ubiquitination	SALVEIPKNCVVAAV HHHEECCCCCEEEEC	69.51	-
193	Ubiquitination	CVVAAVGKELIIFRL CEEEECCCEEEEEEE	42.63	-
216	Ubiquitination	EWDILEVKRLLDHQD CEEHHHHHHHHCCCC	28.14	21906983
221	Ubiquitination	EVKRLLDHQDNILSL HHHHHHCCCCCEEEE	36.54	-
225	Ubiquitination	LLDHQDNILSLINVN HHCCCCCEEEEEECC	3.58	-
264	Ubiquitination	AYERNFWDPSPQLDT HHHHCCCCCCCCCCH	29.66	-
276	Ubiquitination	LDTQQEIKLCQKSND CCHHHHHHHHHHCCC	42.32	-
280	Ubiquitination	QEIKLCQKSNDISIH HHHHHHHHCCCCEEE	50.67	-
290	Phosphorylation	DISIHHFTCDEENVF CCEEEEEECCCCCCE	18.07	-
299	Ubiquitination	DEENVFAAVGRGLYV CCCCCEEEECCCEEE	7.88	-
319	Ubiquitination	KRVIACQKTAHDSNV CEEEEEECCCCCCCC	47.79	-
322	Ubiquitination	IACQKTAHDSNVLHV EEEECCCCCCCCEEE	44.24	-
339	Phosphorylation	LPNRQLISCSEDGSV CCCCCEEEECCCCCE	21.86	29083192
341	Phosphorylation	NRQLISCSEDGSVRI CCCEEEECCCCCEEE	31.75	29083192
354	Ubiquitination	RIWELREKQQLAAEP EEEECHHHHCHHCCC	36.59	-
377	Ubiquitination	WGFGRVSKQASQPVK HCCCCCCCCCCCCCH	47.21	21906983
380	Phosphorylation	GRVSKQASQPVKKQQ CCCCCCCCCCCHHHH	32.30	-
456	Phosphorylation	LEENGDLYLAV---- HHHCCCEEEEC----	9.43	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR41_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR41_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR41_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.