NR3L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR3L1_HUMAN
• UniProt AC: Q68D85
• Protein Name: Natural cytotoxicity triggering receptor 3 ligand 1
• Gene Name: NCR3LG1
• Organism: Homo sapiens (Human).
• Sequence Length: 454
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Triggers NCR3-dependent natural killer cell activation..
• Protein Sequence: MTWRAAASTCAALLILLWALTTEGDLKVEMMAGGTQITPLNDNVTIFCNIFYSQPLNITSMGITWFWKSLTFDKEVKVFEFFGDHQEAFRPGAIVSPWRLKSGDASLRLPGIQLEEAGEYRCEVVVTPLKAQGTVQLEVVASPASRLLLDQVGMKENEDKYMCESSGFYPEAINITWEKQTQKFPHPIEISEDVITGPTIKNMDGTFNVTSCLKLNSSQEDPGTVYQCVVRHASLHTPLRSNFTLTAARHSLSETEKTDNFSIHWWPISFIGVGLVLLIVLIPWKKICNKSSSAYTPLKCILKHWNSFDTQTLKKEHLIFFCTRAWPSYQLQDGEAWPPEGSVNINTIQQLDVFCRQEGKWSEVPYVQAFFALRDNPDLCQCCRIDPALLTVTSGKSIDDNSTKSEKQTPREHSDAVPDAPILPVSPIWEPPPATTSTTPVLSSQPPTLLLPLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	N-linked_Glycosylation	QITPLNDNVTIFCNI EEEECCCCEEEEEEE	31.58	21422170
57	N-linked_Glycosylation	IFYSQPLNITSMGIT EEECCCCEECEEEEE	42.02	21422170
74	Ubiquitination	WKSLTFDKEVKVFEF EEECCCCCEEEEEEE	61.28	-
90	Dimethylation	GDHQEAFRPGAIVSP CCCCHHCCCCCEECC	35.47	-
101	Ubiquitination	IVSPWRLKSGDASLR EECCCCCCCCCCCCC	43.76	29967540
102	Phosphorylation	VSPWRLKSGDASLRL ECCCCCCCCCCCCCC	46.64	-
174	N-linked_Glycosylation	GFYPEAINITWEKQT CCCCEEEEEEEECCC	32.46	UniProtKB CARBOHYD
183	Ubiquitination	TWEKQTQKFPHPIEI EEECCCCCCCCCEEE	65.34	29967540
208	N-linked_Glycosylation	KNMDGTFNVTSCLKL ECCCCCEEEEEEEEC	35.67	21422170
216	N-linked_Glycosylation	VTSCLKLNSSQEDPG EEEEEECCCCCCCCC	37.72	UniProtKB CARBOHYD
226	Phosphorylation	QEDPGTVYQCVVRHA CCCCCCEEEEEEECH	8.95	-
242	N-linked_Glycosylation	LHTPLRSNFTLTAAR CCCCCCCCCEEEEEE	27.73	21422170
260	N-linked_Glycosylation	SETEKTDNFSIHWWP CCCCCCCCCCEECCC	37.48	UniProtKB CARBOHYD
290	Ubiquitination	PWKKICNKSSSAYTP CHHHHCCCCCCCCCC	47.50	29967540
295	Phosphorylation	CNKSSSAYTPLKCIL CCCCCCCCCCHHHHH	15.73	28064214
299	Ubiquitination	SSAYTPLKCILKHWN CCCCCCHHHHHHHHC	22.04	32015554
307	Phosphorylation	CILKHWNSFDTQTLK HHHHHHCCCCCHHCC	21.22	29449344
310	Phosphorylation	KHWNSFDTQTLKKEH HHHCCCCCHHCCHHH	22.80	29449344
314	Ubiquitination	SFDTQTLKKEHLIFF CCCCHHCCHHHEEEE	60.55	29967540
391	Phosphorylation	RIDPALLTVTSGKSI CCCCEEEEEECCCCC	23.69	27690223
393	Phosphorylation	DPALLTVTSGKSIDD CCEEEEEECCCCCCC	26.90	27690223
394	Phosphorylation	PALLTVTSGKSIDDN CEEEEEECCCCCCCC	39.63	21815630
396	Ubiquitination	LLTVTSGKSIDDNST EEEEECCCCCCCCCC	43.96	32015554
397	Phosphorylation	LTVTSGKSIDDNSTK EEEECCCCCCCCCCC	34.47	23312004
402	Phosphorylation	GKSIDDNSTKSEKQT CCCCCCCCCCCCCCC	44.18	27690223
403	Phosphorylation	KSIDDNSTKSEKQTP CCCCCCCCCCCCCCC	44.86	23312004
404	Ubiquitination	SIDDNSTKSEKQTPR CCCCCCCCCCCCCCC	57.34	33845483
405	Phosphorylation	IDDNSTKSEKQTPRE CCCCCCCCCCCCCCC	50.55	24425749
407	Ubiquitination	DNSTKSEKQTPREHS CCCCCCCCCCCCCCC	67.57	-
426	Phosphorylation	DAPILPVSPIWEPPP CCCCCCCCCCCCCCC	14.55	28348404
435	Phosphorylation	IWEPPPATTSTTPVL CCCCCCCCCCCCCCC	27.36	28348404
436	Phosphorylation	WEPPPATTSTTPVLS CCCCCCCCCCCCCCC	26.61	28348404
437	Phosphorylation	EPPPATTSTTPVLSS CCCCCCCCCCCCCCC	26.40	28348404
438	Phosphorylation	PPPATTSTTPVLSSQ CCCCCCCCCCCCCCC	32.78	28348404
439	Phosphorylation	PPATTSTTPVLSSQP CCCCCCCCCCCCCCC	15.92	28348404
443	Phosphorylation	TSTTPVLSSQPPTLL CCCCCCCCCCCCCEE	27.45	28348404
444	Phosphorylation	STTPVLSSQPPTLLL CCCCCCCCCCCCEEE	42.41	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NR3L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR3L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR3L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S14L1_HUMAN	SEC14L1	physical	28514442
RYK_HUMAN	RYK	physical	28514442
ARL2_HUMAN	ARL2	physical	28514442
LRBA_HUMAN	LRBA	physical	28514442
MIGA1_HUMAN	FAM73A	physical	28514442
MMS22_HUMAN	MMS22L	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
PODXL_HUMAN	PODXL	physical	28514442
ATP7A_HUMAN	ATP7A	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
XPO5_HUMAN	XPO5	physical	28514442
GRK6_HUMAN	GRK6	physical	28514442
XPO6_HUMAN	XPO6	physical	28514442
DEGS1_HUMAN	DEGS1	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442
TBCD_HUMAN	TBCD	physical	28514442
ATR_HUMAN	ATR	physical	28514442
TOM40_HUMAN	TOMM40	physical	28514442
PIGG_HUMAN	PIGG	physical	28514442
MYADM_HUMAN	MYADM	physical	28514442
IF1AX_HUMAN	EIF1AX	physical	28514442
COPT1_HUMAN	SLC31A1	physical	28514442
SNX17_HUMAN	SNX17	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structure of the human activating natural cytotoxicity receptor NKp30bound to its tumor cell ligand B7-H6.";
Li Y., Wang Q., Mariuzza R.A.;
J. Exp. Med. 208:703-714(2011).
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 25-262 ALONE AND IN COMPLEXWITH NCR3, GLYCOSYLATION AT ASN-43; ASN-57; ASN-208 AND ASN-242,SUBUNIT, AND DISULFIDE BONDS.
PubMed: 21422170