PIGG_HUMAN - dbPTM
PIGG_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PIGG_HUMAN
UniProt AC Q5H8A4
Protein Name GPI ethanolamine phosphate transferase 2
Gene Name PIGG
Organism Homo sapiens (Human).
Sequence Length 983
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose..
Protein Sequence MRLGSGTFATCCVAIEVLGIAVFLRGFFPAPVRSSARAEHGAEPPAPEPSAGASSNWTTLPPPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGTTSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSKLLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLSLSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVILVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLGDDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWLILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVSKAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKSQVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWASHLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGMHLLITAAVCVFFTAMDQTRLTQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationTLPPPLFSKVVIVLI
CCCCCHHHHHHHHHH		32.0224719451
92PhosphorylationKGVKFMPYTTYLVEK
CCCEECCCEEEEEEC		10.4218083107
93PhosphorylationGVKFMPYTTYLVEKG
CCEECCCEEEEEECC		11.7730206219
94PhosphorylationVKFMPYTTYLVEKGA
CEECCCEEEEEECCC		14.7130206219
95PhosphorylationKFMPYTTYLVEKGAS
EECCCEEEEEECCCC		10.8418083107
120UbiquitinationTVTMPRIKALMTGSL
CCCCHHHHHHHHCCC		36.43-
139PhosphorylationDVIRNLNSPALLEDS
HHHHHCCCCHHHCHH		18.08-
194N-linked_GlycosylationDYTEVDNNVTRHLDK
CCEEECCHHHHHHHH		31.88UniProtKB CARBOHYD
201UbiquitinationNVTRHLDKVLKRGDW
HHHHHHHHHHHCCCC		56.69-
238 (in isoform 3)Ubiquitination-58.4021890473
246 (in isoform 3)Ubiquitination-2.3921890473
249UbiquitinationVLMKIHTSLQSKERE
HHHHHHHHHHCCCCC		15.39-
253UbiquitinationIHTSLQSKERETPLP
HHHHHHCCCCCCCCC		48.07-
257UbiquitinationLQSKERETPLPNLLV
HHCCCCCCCCCCEEE		36.02-
274 (in isoform 3)Ubiquitination-36.3621890473
285UbiquitinationGASSTEEVNTPLILI
CCCCCCCCCCCEEEE		8.66-
312PhosphorylationHPKHVQQTDVAATLA
CCHHHCHHHHHHHHH		18.4919690332
317PhosphorylationQQTDVAATLAIALGL
CHHHHHHHHHHHHCC		13.6419690332
371 (in isoform 2)Ubiquitination-62.0721890473
371 (in isoform 4)Ubiquitination-62.0721890473
371 (in isoform 1)Ubiquitination-62.0721890473
371UbiquitinationENVPSYEKDPGFEQF
HCCCCCCCCCCCHHH		62.0721906983
379 (in isoform 4)Ubiquitination-41.0121890473
379 (in isoform 2)Ubiquitination-41.0121890473
379UbiquitinationDPGFEQFKMSERLHG
CCCCHHHHHHHHHCC		41.0121906983
379 (in isoform 1)Ubiquitination-41.0121890473
407 (in isoform 4)Ubiquitination-43.4121890473
407UbiquitinationVLFNLGSKVLRQYLD
HHHHHCHHHHHHHHH		43.4121890473
407 (in isoform 2)Ubiquitination-43.4121890473
407 (in isoform 1)Ubiquitination-43.4121890473
407UbiquitinationVLFNLGSKVLRQYLD
HHHHHCHHHHHHHHH		43.4121890473
502 (in isoform 3)Ubiquitination-16.9121890473
627 (in isoform 2)Ubiquitination-26.2821890473
635 (in isoform 1)Ubiquitination-60.0521890473
635UbiquitinationCDVLERDKGHGSPST
CCEEECCCCCCCCCH		60.052190698
639PhosphorylationERDKGHGSPSTSEVL
ECCCCCCCCCHHHHH		15.2525159151
641PhosphorylationDKGHGSPSTSEVLRG
CCCCCCCCHHHHHCC		46.3829083192
642PhosphorylationKGHGSPSTSEVLRGR
CCCCCCCHHHHHCCH		32.0821712546
643PhosphorylationGHGSPSTSEVLRGRE
CCCCCCHHHHHCCHH		30.0025159151
750AcetylationFPWRPDSKDISKGII
CCCCCCCCCCCHHHH		67.4788439
754AcetylationPDSKDISKGIIEARF
CCCCCCCHHHHHHHH		55.2388443
952PhosphorylationLFIWSVFSPKLLYEG
HHHHHHCCHHHHHHH		20.9724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PIGG_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PIGG_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PIGG_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
PIGF_MOUSEPigfphysical
15632136
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PIGG_HUMAN

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Related Literatures of Post-Translational Modification

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