| UniProt ID | I17RB_HUMAN | |
|---|---|---|
| UniProt AC | Q9NRM6 | |
| Protein Name | Interleukin-17 receptor B | |
| Gene Name | IL17RB | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 502 | |
| Subcellular Localization |
Isoform 1: Cell membrane Single-pass type I membrane protein. Isoform 2: Secreted. |
|
| Protein Description | Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.. | |
| Protein Sequence | MSLVLLSLAALCRSAVPREPTVQCGSETGPSPEWMLQHDLIPGDLRDLRVEPVTTSVATGDYSILMNVSWVLRADASIRLLKATKICVTGKSNFQSYSCVRCNYTEAFQTQTRPSGGKWTFSYIGFPVELNTVYFIGAHNIPNANMNEDGPSMSVNFTSPGCLDHIMKYKKKCVKAGSLWDPNITACKKNEETVEVNFTTTPLGNRYMALIQHSTIIGFSQVFEPHQKKQTRASVVIPVTGDSEGATVQLTPYFPTCGSDCIRHKGTVVLCPQTGVPFPLDNNKSKPGGWLPLLLLSLLVATWVLVAGIYLMWRHERIKKTSFSTTTLLPPIKVLVVYPSEICFHHTICYFTEFLQNHCRSEVILEKWQKKKIAEMGPVQWLATQKKAADKVVFLLSNDVNSVCDGTCGKSEGSPSENSQDLFPLAFNLFCSDLRSQIHLHKYVVVYFREIDTKDDYNALSVCPKYHLMKDATAFCAELLHVKQQVSAGKRSQACHDGCCSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | N-linked_Glycosylation | GDYSILMNVSWVLRA CCCEEEEEHHHHHCC | 22.64 | UniProtKB CARBOHYD | |
| 92 | Phosphorylation | KICVTGKSNFQSYSC EEEEECCCCCCEEEE | 44.19 | - | |
| 96 | Phosphorylation | TGKSNFQSYSCVRCN ECCCCCCEEEEEECC | 18.18 | - | |
| 97 | Phosphorylation | GKSNFQSYSCVRCNY CCCCCCEEEEEECCC | 8.70 | - | |
| 98 | Phosphorylation | KSNFQSYSCVRCNYT CCCCCEEEEEECCCE | 16.04 | - | |
| 103 | N-linked_Glycosylation | SYSCVRCNYTEAFQT EEEEEECCCEEEEEC | 35.88 | UniProtKB CARBOHYD | |
| 156 | N-linked_Glycosylation | DGPSMSVNFTSPGCL CCCCCCEECCCCCHH | 27.46 | UniProtKB CARBOHYD | |
| 183 | N-linked_Glycosylation | AGSLWDPNITACKKN CCCCCCCCCCEECCC | 41.59 | UniProtKB CARBOHYD | |
| 197 | N-linked_Glycosylation | NEETVEVNFTTTPLG CCCEEEEEEEECCCC | 18.29 | UniProtKB CARBOHYD | |
| 283 | N-linked_Glycosylation | VPFPLDNNKSKPGGW CCCCCCCCCCCCCCH | 50.04 | UniProtKB CARBOHYD | |
| 310 | Phosphorylation | WVLVAGIYLMWRHER HHHHHHHHHHHHHHH | 6.92 | 26074081 | |
| 321 | Phosphorylation | RHERIKKTSFSTTTL HHHHCCCCCCCCCCC | 29.96 | 26074081 | |
| 322 | Phosphorylation | HERIKKTSFSTTTLL HHHCCCCCCCCCCCC | 26.53 | 26074081 | |
| 324 | Phosphorylation | RIKKTSFSTTTLLPP HCCCCCCCCCCCCCC | 25.31 | 26074081 | |
| 325 | Phosphorylation | IKKTSFSTTTLLPPI CCCCCCCCCCCCCCE | 23.07 | 26074081 | |
| 326 | Phosphorylation | KKTSFSTTTLLPPIK CCCCCCCCCCCCCEE | 17.78 | 26074081 | |
| 327 | Phosphorylation | KTSFSTTTLLPPIKV CCCCCCCCCCCCEEE | 26.79 | 26074081 | |
| 402 | Phosphorylation | LLSNDVNSVCDGTCG EECCCCCHHCCCCCC | 24.78 | 23532336 | |
| 407 | Phosphorylation | VNSVCDGTCGKSEGS CCHHCCCCCCCCCCC | 12.58 | 23532336 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of I17RB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of I17RB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of I17RB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| IL17B_HUMAN | IL17B | physical | 10749887 | |
| DAZP2_HUMAN | DAZAP2 | physical | 22070932 | |
| KS6A5_HUMAN | RPS6KA5 | physical | 21988832 | |
| SELO_HUMAN | SELO | physical | 28514442 | |
| RNFT1_HUMAN | RNFT1 | physical | 28514442 | |
| CSCL2_HUMAN | TMEM63B | physical | 28514442 | |
| PIGQ_HUMAN | PIGQ | physical | 28514442 | |
| AT2A3_HUMAN | ATP2A3 | physical | 28514442 | |
| BMR1A_HUMAN | BMPR1A | physical | 28514442 | |
| STIM1_HUMAN | STIM1 | physical | 28514442 | |
| RETST_HUMAN | RETSAT | physical | 28514442 | |
| ST7L_HUMAN | ST7L | physical | 28514442 | |
| RHBT3_HUMAN | RHOBTB3 | physical | 28514442 | |
| BT2A2_HUMAN | BTN2A2 | physical | 28514442 | |
| TYW1_HUMAN | TYW1 | physical | 28514442 | |
| RN149_HUMAN | RNF149 | physical | 28514442 | |
| MFAP3_HUMAN | MFAP3 | physical | 28514442 | |
| AMGO1_HUMAN | AMIGO1 | physical | 28514442 | |
| ZNT1_HUMAN | SLC30A1 | physical | 28514442 | |
| HLAF_HUMAN | HLA-F | physical | 28514442 | |
| S35F5_HUMAN | SLC35F5 | physical | 28514442 | |
| AVR2B_HUMAN | ACVR2B | physical | 28514442 | |
| EPHA7_HUMAN | EPHA7 | physical | 28514442 | |
| CISD2_HUMAN | CISD2 | physical | 28514442 | |
| ANKL2_HUMAN | ANKLE2 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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