dbPTM

KS6A5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KS6A5_HUMAN
UniProt AC	O75582
Protein Name	Ribosomal protein S6 kinase alpha-5
Gene Name	RPS6KA5
Organism	Homo sapiens (Human).
Sequence Length	802
Subcellular Localization	Nucleus. Cytoplasm. Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid.
Protein Description	Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. [PubMed: 11909979]
Protein Sequence	MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEEEGGSSGGAAGT -CCCCCCCCCCCCCC	36.34	28348404
8	Phosphorylation	MEEEGGSSGGAAGTS CCCCCCCCCCCCCCC	44.51	24719451
14	Phosphorylation	SSGGAAGTSADGGDG CCCCCCCCCCCCCCC	18.93	28348404
15	Phosphorylation	SGGAAGTSADGGDGG CCCCCCCCCCCCCCC	24.36	22210691
15	Ubiquitination	SGGAAGTSADGGDGG CCCCCCCCCCCCCCC	24.36	24816145
29	Ubiquitination	GEQLLTVKHELRTAN CCEEEEEEHHHHHCC	26.57	24816145
32	Ubiquitination	LLTVKHELRTANLTG EEEEEHHHHHCCCCC	6.20	29967540
34	Phosphorylation	TVKHELRTANLTGHA EEEHHHHHCCCCCCH	32.30	28555341
38	Phosphorylation	ELRTANLTGHAEKVG HHHHCCCCCCHHHHC	27.08	24719451
46	Ubiquitination	GHAEKVGIENFELLK CCHHHHCCCCCCHHE	4.36	29967540
48	Ubiquitination	AEKVGIENFELLKVL HHHHCCCCCCHHEHH	33.50	29967540
53	Ubiquitination	IENFELLKVLGTGAY CCCCCHHEHHCCCCC	48.30	22817900
54	Ubiquitination	ENFELLKVLGTGAYG CCCCHHEHHCCCCCC	6.34	29967540
57	Phosphorylation	ELLKVLGTGAYGKVF CHHEHHCCCCCCEEE	17.93	19835603
57	Ubiquitination	ELLKVLGTGAYGKVF CHHEHHCCCCCCEEE	17.93	24816145
60	Phosphorylation	KVLGTGAYGKVFLVR EHHCCCCCCEEEEEE	20.87	22817900
62	Ubiquitination	LGTGAYGKVFLVRKI HCCCCCCEEEEEEEE	19.69	29967540
74	Ubiquitination	RKISGHDTGKLYAMK EEECCCCCHHHHHHH	30.46	29967540
77	Ubiquitination	SGHDTGKLYAMKVLK CCCCCHHHHHHHHHH	3.31	24816145
78	Phosphorylation	GHDTGKLYAMKVLKK CCCCHHHHHHHHHHH	14.24	28060719
81	Ubiquitination	TGKLYAMKVLKKATI CHHHHHHHHHHHCEE	35.92	29967540
90	Ubiquitination	LKKATIVQKAKTTEH HHHCEEEEECCCCCC	35.82	29967540
94	Ubiquitination	TIVQKAKTTEHTRTE EEEEECCCCCCCHHH	42.13	29967540
104	Ubiquitination	HTRTERQVLEHIRQS CCHHHHHHHHHHHHC	9.43	24816145
110	Ubiquitination	QVLEHIRQSPFLVTL HHHHHHHHCCCEEEE	55.65	29967540
121	Ubiquitination	LVTLHYAFQTETKLH EEEEEEEECCCCCEE	7.92	29967540
137	Ubiquitination	ILDYINGGELFTHLS EEEHHCCCCHHHHHH	24.76	29967540
147	Ubiquitination	FTHLSQRERFTEHEV HHHHHHHHCCCHHHH	44.50	29967540
149	Ubiquitination	HLSQRERFTEHEVQI HHHHHHCCCHHHHHH	8.89	29967540
161	Ubiquitination	VQIYVGEIVLALEHL HHHHHHHHHHHHHHH	2.24	29967540
163	Ubiquitination	IYVGEIVLALEHLHK HHHHHHHHHHHHHHH	5.75	29967540
175	Phosphorylation	LHKLGIIYRDIKLEN HHHCCCEEECCCHHH	10.58	20860994
187	O-linked_Glycosylation	LENILLDSNGHVVLT HHHEEECCCCCEEEE	44.68	23301498
189	Ubiquitination	NILLDSNGHVVLTDF HEEECCCCCEEEECC	20.93	29967540
191	Ubiquitination	LLDSNGHVVLTDFGL EECCCCCEEEECCCC	3.91	29967540
192	Ubiquitination	LDSNGHVVLTDFGLS ECCCCCEEEECCCCC	3.85	29967540
194	Phosphorylation	SNGHVVLTDFGLSKE CCCCEEEECCCCCHH	20.06	21082442
194	Ubiquitination	SNGHVVLTDFGLSKE CCCCEEEECCCCCHH	20.06	29967540
199	Phosphorylation	VLTDFGLSKEFVADE EEECCCCCHHHHCCC	30.44	29396449
200	Ubiquitination	LTDFGLSKEFVADET EECCCCCHHHHCCCH	61.28	29967540
206	Ubiquitination	SKEFVADETERAYSF CHHHHCCCHHHHHHH	42.71	29967540
209	Ubiquitination	FVADETERAYSFCGT HHCCCHHHHHHHHCC	46.36	29967540
211	Phosphorylation	ADETERAYSFCGTIE CCCHHHHHHHHCCEE	14.43	22210691
211	Ubiquitination	ADETERAYSFCGTIE CCCHHHHHHHHCCEE	14.43	29967540
212	Phosphorylation	DETERAYSFCGTIEY CCHHHHHHHHCCEEE	17.05	15568999
216	Phosphorylation	RAYSFCGTIEYMAPD HHHHHHCCEEEECCC	16.30	28857561
217	Ubiquitination	AYSFCGTIEYMAPDI HHHHHCCEEEECCCH	1.85	24816145
219	Phosphorylation	SFCGTIEYMAPDIVR HHHCCEEEECCCHHC	8.50	28102081
223	Ubiquitination	TIEYMAPDIVRGGDS CEEEECCCHHCCCCC	42.34	24816145
234	Ubiquitination	GGDSGHDKAVDWWSL CCCCCCHHHHHHHHH	44.64	29967540
236	Ubiquitination	DSGHDKAVDWWSLGV CCCCHHHHHHHHHHH	8.57	29967540
237	Ubiquitination	SGHDKAVDWWSLGVL CCCHHHHHHHHHHHH	46.09	29967540
238	Ubiquitination	GHDKAVDWWSLGVLM CCHHHHHHHHHHHHH	4.67	29967540
240	Phosphorylation	DKAVDWWSLGVLMYE HHHHHHHHHHHHHHH	15.81	-
240	Ubiquitination	DKAVDWWSLGVLMYE HHHHHHHHHHHHHHH	15.81	29967540
245	Ubiquitination	WWSLGVLMYELLTGA HHHHHHHHHHHHHCC	1.96	29967540
246	Ubiquitination	WSLGVLMYELLTGAS HHHHHHHHHHHHCCC	10.16	29967540
250	Ubiquitination	VLMYELLTGASPFTV HHHHHHHHCCCCCCC	43.24	29967540
253	Phosphorylation	YELLTGASPFTVDGE HHHHHCCCCCCCCCC	23.14	-
254	Ubiquitination	ELLTGASPFTVDGEK HHHHCCCCCCCCCCC	28.52	29967540
256	Ubiquitination	LTGASPFTVDGEKNS HHCCCCCCCCCCCCC	22.52	29967540
260	Ubiquitination	SPFTVDGEKNSQAEI CCCCCCCCCCCHHHH	44.60	24816145
265	Ubiquitination	DGEKNSQAEISRRIL CCCCCCHHHHHHHHH	18.86	29967540
268	Phosphorylation	KNSQAEISRRILKSE CCCHHHHHHHHHHCC	13.65	-
268	Ubiquitination	KNSQAEISRRILKSE CCCHHHHHHHHHHCC	13.65	24816145
273	Ubiquitination	EISRRILKSEPPYPQ HHHHHHHHCCCCCHH	50.86	29967540
277	Ubiquitination	RILKSEPPYPQEMSA HHHHCCCCCHHHHHH	49.76	29967540
279	Ubiquitination	LKSEPPYPQEMSALA HHCCCCCHHHHHHHH	29.45	29967540
281	Ubiquitination	SEPPYPQEMSALAKD CCCCCHHHHHHHHHH	30.51	29967540
285	Ubiquitination	YPQEMSALAKDLIQR CHHHHHHHHHHHHHH	4.83	29967540
288	Ubiquitination	EMSALAKDLIQRLLM HHHHHHHHHHHHHHC	43.31	29967540
293	Ubiquitination	AKDLIQRLLMKDPKK HHHHHHHHHCCCHHH	2.92	29967540
296	Ubiquitination	LIQRLLMKDPKKRLG HHHHHHCCCHHHHCC	71.49	24816145
301	Ubiquitination	LMKDPKKRLGCGPRD HCCCHHHHCCCCCCC	42.30	29967540
307	Ubiquitination	KRLGCGPRDADEIKE HHCCCCCCCHHHHHH	36.71	29967540
308	Ubiquitination	RLGCGPRDADEIKEH HCCCCCCCHHHHHHH	62.60	29967540
313	Ubiquitination	PRDADEIKEHLFFQK CCCHHHHHHHHHEEE	36.71	29967540
327	Ubiquitination	KINWDDLAAKKVPAP ECCHHHHHHCCCCCC	24.99	29967540
329	Ubiquitination	NWDDLAAKKVPAPFK CHHHHHHCCCCCCCC	49.01	29967540
335	Ubiquitination	AKKVPAPFKPVIRDE HCCCCCCCCCCCCCC	17.73	29967540
346	Phosphorylation	IRDELDVSNFAEEFT CCCCCCHHHHHHHHH	26.37	27499020
349	Ubiquitination	ELDVSNFAEEFTEMD CCCHHHHHHHHHHCC	21.47	29967540
351	Ubiquitination	DVSNFAEEFTEMDPT CHHHHHHHHHHCCCC	55.21	29967540
353	Phosphorylation	SNFAEEFTEMDPTYS HHHHHHHHHCCCCCC	33.41	22468782
354	Ubiquitination	NFAEEFTEMDPTYSP HHHHHHHHCCCCCCC	47.08	29967540
355	Ubiquitination	FAEEFTEMDPTYSPA HHHHHHHCCCCCCCC	7.31	29967540
357	Ubiquitination	EEFTEMDPTYSPAAL HHHHHCCCCCCCCCC	31.74	29967540
358	Phosphorylation	EFTEMDPTYSPAALP HHHHCCCCCCCCCCC	32.16	22468782
359	Phosphorylation	FTEMDPTYSPAALPQ HHHCCCCCCCCCCCC	20.32	26657352
360	Phosphorylation	TEMDPTYSPAALPQS HHCCCCCCCCCCCCC	15.56	15568999
367	Phosphorylation	SPAALPQSSEKLFQG CCCCCCCCHHHHHCC	38.23	28348404
368	Phosphorylation	PAALPQSSEKLFQGY CCCCCCCHHHHHCCC	33.24	28348404
373	Ubiquitination	QSSEKLFQGYSFVAP CCHHHHHCCCCCCCH	61.42	29967540
374	Ubiquitination	SSEKLFQGYSFVAPS CHHHHHCCCCCCCHH	16.84	29967540
375	Phosphorylation	SEKLFQGYSFVAPSI HHHHHCCCCCCCHHH	6.53	23663014
376	Phosphorylation	EKLFQGYSFVAPSIL HHHHCCCCCCCHHHH	21.77	22322096
376	Ubiquitination	EKLFQGYSFVAPSIL HHHHCCCCCCCHHHH	21.77	29967540
380	Ubiquitination	QGYSFVAPSILFKRN CCCCCCCHHHHCCCC	19.32	29967540
381	Phosphorylation	GYSFVAPSILFKRNA CCCCCCHHHHCCCCC	23.37	22322096
385	Ubiquitination	VAPSILFKRNAAVID CCHHHHCCCCCEECC	41.10	-
387	Ubiquitination	PSILFKRNAAVIDPL HHHHCCCCCEECCCC	32.61	29967540
392	Ubiquitination	KRNAAVIDPLQFHMG CCCCEECCCCHHCCC	31.12	29967540
393	Ubiquitination	RNAAVIDPLQFHMGV CCCEECCCCHHCCCC	19.55	29967540
394	Ubiquitination	NAAVIDPLQFHMGVE CCEECCCCHHCCCCC	8.24	29967540
396	Ubiquitination	AVIDPLQFHMGVERP EECCCCHHCCCCCCC	5.89	29967540
400	Ubiquitination	PLQFHMGVERPGVTN CCHHCCCCCCCCCCH	4.36	29967540
402	Ubiquitination	QFHMGVERPGVTNVA HHCCCCCCCCCCHHH	30.76	29967540
407	Ubiquitination	VERPGVTNVARSAMM CCCCCCCHHHHHHHH	24.05	29967540
410	Ubiquitination	PGVTNVARSAMMKDS CCCCHHHHHHHHCCC	22.21	29967540
415	Ubiquitination	VARSAMMKDSPFYQH HHHHHHHCCCCCCCC	41.80	29967540
419	Ubiquitination	AMMKDSPFYQHYDLD HHHCCCCCCCCCCCC	12.11	29967540
422	Ubiquitination	KDSPFYQHYDLDLKD CCCCCCCCCCCCCCC	13.49	29967540
428	Ubiquitination	QHYDLDLKDKPLGEG CCCCCCCCCCCCCCC	64.47	29967540
430	Ubiquitination	YDLDLKDKPLGEGSF CCCCCCCCCCCCCCH	40.32	29967540
435	Ubiquitination	KDKPLGEGSFSICRK CCCCCCCCCHHHHHH	31.99	29967540
436	Phosphorylation	DKPLGEGSFSICRKC CCCCCCCCHHHHHHH	16.12	27080861
437	Ubiquitination	KPLGEGSFSICRKCV CCCCCCCHHHHHHHH	9.31	29967540
438	Phosphorylation	PLGEGSFSICRKCVH CCCCCCHHHHHHHHH	23.60	27080861
438	Ubiquitination	PLGEGSFSICRKCVH CCCCCCHHHHHHHHH	23.60	29967540
442	Ubiquitination	GSFSICRKCVHKKSN CCHHHHHHHHHCCCC	35.88	29967540
445	Ubiquitination	SICRKCVHKKSNQAF HHHHHHHHCCCCHHH	41.10	29967540
448	Phosphorylation	RKCVHKKSNQAFAVK HHHHHCCCCHHHHHH	38.69	24247654
448	Ubiquitination	RKCVHKKSNQAFAVK HHHHHCCCCHHHHHH	38.69	29967540
454	Ubiquitination	KSNQAFAVKIISKRM CCCHHHHHHHHHHHH	3.55	29967540
455	Ubiquitination	SNQAFAVKIISKRME CCHHHHHHHHHHHHH	30.78	29967540
458	Ubiquitination	AFAVKIISKRMEANT HHHHHHHHHHHHHCC	20.06	29967540
462	Ubiquitination	KIISKRMEANTQKEI HHHHHHHHHCCHHHH	42.68	29967540
467	Ubiquitination	RMEANTQKEITALKL HHHHCCHHHHHHHHH	49.39	29967540
469	Ubiquitination	EANTQKEITALKLCE HHCCHHHHHHHHHHC	3.35	29967540
473	Acetylation	QKEITALKLCEGHPN HHHHHHHHHHCCCCC	48.94	25953088
473	Ubiquitination	QKEITALKLCEGHPN HHHHHHHHHHCCCCC	48.94	29967540
482	Ubiquitination	CEGHPNIVKLHEVFH HCCCCCEEEHHHHHH	7.39	29967540
485	Ubiquitination	HPNIVKLHEVFHDQL CCCEEEHHHHHHHHH	24.37	29967540
491	Ubiquitination	LHEVFHDQLHTFLVM HHHHHHHHHHHHHHH	26.94	29967540
492	Ubiquitination	HEVFHDQLHTFLVME HHHHHHHHHHHHHHH	5.24	29967540
499	Ubiquitination	LHTFLVMELLNGGEL HHHHHHHHHHCCHHH	42.50	29967540
510	Ubiquitination	GGELFERIKKKKHFS CHHHHHHHHHCCCCC	6.37	29967540
518	Ubiquitination	KKKKHFSETEASYIM HHCCCCCHHHHHHHH	50.12	29967540
527	Ubiquitination	EASYIMRKLVSAVSH HHHHHHHHHHHHHHH	35.54	29967540
546	Ubiquitination	GVVHRDLKPENLLFT CEECCCCCHHHCEEE	55.35	29967540
575	Ubiquitination	FARLKPPDNQPLKTP CCCCCCCCCCCCCCC	74.95	29967540
581	Phosphorylation	PDNQPLKTPCFTLHY CCCCCCCCCCEEHHH	32.73	19940164
581	Ubiquitination	PDNQPLKTPCFTLHY CCCCCCCCCCEEHHH	32.73	29967540
582	Ubiquitination	DNQPLKTPCFTLHYA CCCCCCCCCEEHHHC	15.05	29967540
588	Ubiquitination	TPCFTLHYAAPELLN CCCEEHHHCCHHHHH	13.94	29967540
595	Ubiquitination	YAAPELLNQNGYDES HCCHHHHHCCCCCCC	45.99	29967540
598	Ubiquitination	PELLNQNGYDESCDL HHHHHCCCCCCCCHH	22.85	29967540
600	Ubiquitination	LLNQNGYDESCDLWS HHHCCCCCCCCHHHH	42.61	29967540
601	Ubiquitination	LNQNGYDESCDLWSL HHCCCCCCCCHHHHH	44.79	29967540
604	Ubiquitination	NGYDESCDLWSLGVI CCCCCCCHHHHHHHH	61.52	29967540
607	Ubiquitination	DESCDLWSLGVILYT CCCCHHHHHHHHHHH	23.65	29967540
618	Ubiquitination	ILYTMLSGQVPFQSH HHHHHHHCCCCCCCC	28.66	29967540
620	Ubiquitination	YTMLSGQVPFQSHDR HHHHHCCCCCCCCCC	6.14	29967540
623	Ubiquitination	LSGQVPFQSHDRSLT HHCCCCCCCCCCCCE	33.51	29967540
625	Ubiquitination	GQVPFQSHDRSLTCT CCCCCCCCCCCCEEC	24.58	29967540
626	Ubiquitination	QVPFQSHDRSLTCTS CCCCCCCCCCCEECC	47.30	29967540
628	Phosphorylation	PFQSHDRSLTCTSAV CCCCCCCCCEECCHH	33.80	25850435
630	Phosphorylation	QSHDRSLTCTSAVEI CCCCCCCEECCHHHH	18.25	28857561
633	Phosphorylation	DRSLTCTSAVEIMKK CCCCEECCHHHHHHH	32.25	24719451
633	Ubiquitination	DRSLTCTSAVEIMKK CCCCEECCHHHHHHH	32.25	29967540
638	Ubiquitination	CTSAVEIMKKIKKGD ECCHHHHHHHHHCCC	1.98	29967540
641	Ubiquitination	AVEIMKKIKKGDFSF HHHHHHHHHCCCCCC	4.68	29967540
646	Ubiquitination	KKIKKGDFSFEGEAW HHHHCCCCCCCCHHH	14.20	29967540
647	Phosphorylation	KIKKGDFSFEGEAWK HHHCCCCCCCCHHHH	27.42	17117922
647	Ubiquitination	KIKKGDFSFEGEAWK HHHCCCCCCCCHHHH	27.42	29967540
649	Ubiquitination	KKGDFSFEGEAWKNV HCCCCCCCCHHHHCC	55.73	29967540
654	Ubiquitination	SFEGEAWKNVSQEAK CCCCHHHHCCCHHHH	55.29	29967540
657	Phosphorylation	GEAWKNVSQEAKDLI CHHHHCCCHHHHHHH	31.53	17117922
661	Ubiquitination	KNVSQEAKDLIQGLL HCCCHHHHHHHHHHC	52.92	29967540
667	Ubiquitination	AKDLIQGLLTVDPNK HHHHHHHHCCCCCCC	1.76	29967540
670	Ubiquitination	LIQGLLTVDPNKRLK HHHHHCCCCCCCCEE	13.37	29967540
674	Ubiquitination	LLTVDPNKRLKMSGL HCCCCCCCCEEECCC	65.58	29967540
677	Ubiquitination	VDPNKRLKMSGLRYN CCCCCCEEECCCCHH	34.74	29967540
683	Phosphorylation	LKMSGLRYNEWLQDG EEECCCCHHHHHCCC	23.60	27251275
691	Phosphorylation	NEWLQDGSQLSSNPL HHHHCCCCCCCCCCC	35.92	27251275
694	Phosphorylation	LQDGSQLSSNPLMTP HCCCCCCCCCCCCCH	22.04	24247654
695	Phosphorylation	QDGSQLSSNPLMTPD CCCCCCCCCCCCCHH	51.57	17117922
700	Phosphorylation	LSSNPLMTPDILGSS CCCCCCCCHHHHCCC	26.03	17117922
749	Phosphorylation	KRRKMKKTSTSTETR HHHCCCCCCCCCCCC	31.55	30576142
750	Phosphorylation	RRKMKKTSTSTETRS HHCCCCCCCCCCCCC	29.28	15568999
751	Phosphorylation	RKMKKTSTSTETRSS HCCCCCCCCCCCCCC	44.92	30576142
752	Phosphorylation	KMKKTSTSTETRSSS CCCCCCCCCCCCCCC	24.82	15568999
755	Phosphorylation	KTSTSTETRSSSSES CCCCCCCCCCCCCCC	35.62	30576142
757	Phosphorylation	STSTETRSSSSESSH CCCCCCCCCCCCCCC	41.83	22817900
758	Phosphorylation	TSTETRSSSSESSHS CCCCCCCCCCCCCCC	34.29	30576142
759	Phosphorylation	STETRSSSSESSHSS CCCCCCCCCCCCCCC	39.10	22817900
760	Phosphorylation	TETRSSSSESSHSSS CCCCCCCCCCCCCCC	43.37	30576142
763	Phosphorylation	RSSSSESSHSSSSHS CCCCCCCCCCCCCCC	24.28	30576142
766	Phosphorylation	SSESSHSSSSHSHGK CCCCCCCCCCCCCCC	30.36	28348404
767	Phosphorylation	SESSHSSSSHSHGKT CCCCCCCCCCCCCCC	34.78	28348404
768	Phosphorylation	ESSHSSSSHSHGKTT CCCCCCCCCCCCCCC	30.84	28348404
770	Phosphorylation	SHSSSSHSHGKTTPT CCCCCCCCCCCCCCC	35.56	28348404
774	Phosphorylation	SSHSHGKTTPTKTLQ CCCCCCCCCCCCCCC	42.47	24719451
775	Phosphorylation	SHSHGKTTPTKTLQP CCCCCCCCCCCCCCC	32.23	28348404
779	Phosphorylation	GKTTPTKTLQPSNPA CCCCCCCCCCCCCCC	32.86	22210691
788	Phosphorylation	QPSNPADSNNPETLF CCCCCCCCCCHHHHE	40.38	24719451
793	Phosphorylation	ADSNNPETLFQFSDS CCCCCHHHHEEECCC	33.84	22817900
798	Phosphorylation	PETLFQFSDSVA--- HHHHEEECCCCC---	20.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
212	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
360	S	Phosphorylation	Kinase	MK14	Q16539	PhosphoELM
360	S	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
360	S	Phosphorylation	Kinase	MK01	P28482	PhosphoELM
376	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
381	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
581	T	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
581	T	Phosphorylation	Kinase	MK14	Q16539	PhosphoELM
581	T	Phosphorylation	Kinase	MK01	P28482	PhosphoELM
700	T	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
700	T	Phosphorylation	Kinase	MAPK3	P27361	Uniprot
700	T	Phosphorylation	Kinase	MAPK14	Q16539	Uniprot
700	T	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
750	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
752	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
757	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
757	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
758	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
758	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
758	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
759	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
759	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
760	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
760	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
793	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
793	T	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
212	S	Phosphorylation	15568999
Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.
360	S	Phosphorylation	15568999
Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.
376	S	Phosphorylation	15568999
Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.
376	S	Phosphorylation	15568999
Ser-376 and Thr-581 phosphorylation is required for kinase activity.
581	T	Phosphorylation	15568999
Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.
581	T	Phosphorylation	15568999
Ser-376 and Thr-581 phosphorylation is required for kinase activity.
700	T	Phosphorylation	17117922
Phosphorylated at Ser-360, Thr-581 and Thr-700 by MAPK1/ERK2, MAPK3/ERK1 and MAPK14/p38-alpha.
750	S	Phosphorylation	15568999
Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.
752	S	Phosphorylation	15568999
Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.
758	S	Phosphorylation	15568999
Autophosphorylated at Ser-750, Ser-752 and Ser-758 by the N-terminal kinase domain.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KS6A5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK01_HUMAN	MAPK1	genetic	9687510
MK11_HUMAN	MAPK11	genetic	9687510
EGF_HUMAN	EGF	genetic	9687510
CREB1_HUMAN	CREB1	physical	9687510
BAD_HUMAN	BAD	physical	11500364
CREB1_HUMAN	CREB1	physical	11500364
H32_HUMAN	HIST2H3C	physical	15010469
H2B2E_HUMAN	HIST2H2BE	physical	15010469
DDAH2_HUMAN	DDAH2	physical	21900206
ERH_HUMAN	ERH	physical	21900206
U119A_HUMAN	UNC119	physical	21900206
ZN775_HUMAN	ZNF775	physical	21900206
ACTG_HUMAN	ACTG1	physical	21900206
ROBO2_HUMAN	ROBO2	physical	21900206
PDLI1_HUMAN	PDLIM1	physical	21900206
RAI1_HUMAN	RAI1	physical	21900206
AKTS1_HUMAN	AKT1S1	physical	21900206
RN19A_HUMAN	RNF19A	physical	21900206
DPYL1_HUMAN	CRMP1	physical	21900206
SMAD6_HUMAN	SMAD6	physical	21900206
DJC11_HUMAN	DNAJC11	physical	21900206
ITSN1_HUMAN	ITSN1	physical	21900206
SNF5_HUMAN	SMARCB1	physical	21900206
EZH2_HUMAN	EZH2	physical	21900206
CREB1_HUMAN	CREB1	physical	9873047
ETV1_HUMAN	ETV1	physical	12569367
EP300_HUMAN	EP300	physical	12569367
CBP_HUMAN	CREBBP	physical	12569367
SMCA4_HUMAN	SMARCA4	physical	20129940
1433Z_HUMAN	YWHAZ	physical	20129940
NFKB1_HUMAN	NFKB1	physical	20129940
A4_HUMAN	APP	physical	21832049
TAU_HUMAN	MAPT	physical	17512525
TF65_HUMAN	RELA	physical	12628924
GCR_HUMAN	NR3C1	physical	18511904
M3K20_HUMAN	ZAK	physical	21988832
TXD11_HUMAN	TXNDC11	physical	21988832
H2B1B_HUMAN	HIST1H2BB	physical	9873047
MBP_HUMAN	MBP	physical	9873047
H11_HUMAN	HIST1H1A	physical	9873047
TF65_HUMAN	RELA	physical	25241761
EGF_HUMAN	EGF	physical	25241761
ATF2_HUMAN	ATF2	physical	25241761
ATF1_HUMAN	ATF1	physical	11335727
MK14_HUMAN	MAPK14	physical	10922375

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KS6A5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Identification of novel phosphorylation sites in MSK1 by precursorion scanning MS."; McCoy C.E., Macdonald A., Morrice N.A., Campbell D.G., Deak M.,Toth R., McIlrath J., Arthur J.S.; Biochem. J. 402:491-501(2007). Cited for: PHOSPHORYLATION AT SER-647; SER-657; SER-695 AND THR-700, ANDMUTAGENESIS OF THR-700.	17117922 [Abstract]
"MSK1 activity is controlled by multiple phosphorylation sites."; McCoy C.E., Campbell D.G., Deak M., Bloomberg G.B., Arthur J.S.C.; Biochem. J. 387:507-517(2005). Cited for: ENZYME REGULATION, PHOSPHORYLATION AT SER-212; SER-360; SER-376;SER-381; THR-581; SER-750; SER-752 AND SER-758, AND MUTAGENESIS OFSER-212; SER-360; SER-376 AND THR-581.	15568999 [Abstract]

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