| UniProt ID | M3K20_HUMAN | |
|---|---|---|
| UniProt AC | Q9NYL2 | |
| Protein Name | Mitogen-activated protein kinase kinase kinase 20 {ECO:0000312|HGNC:HGNC:17797} | |
| Gene Name | MAP3K20 {ECO:0000312|HGNC:HGNC:17797} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 800 | |
| Subcellular Localization | Cytoplasm . Nucleus . Translocates to the nucleus upon ultraviolet B irradiation. | |
| Protein Description | Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. [PubMed: 10924358] | |
| Protein Sequence | MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFSSGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQSALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRPSPAKTNKERARGDHRGWRNF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSSLGASFV ------CCCCCCCEE | 19369195 | ||
| 2 | Phosphorylation | ------MSSLGASFV ------CCCCCCCEE | 25159151 | ||
| 3 | Phosphorylation | -----MSSLGASFVQ -----CCCCCCCEEE | 25159151 | ||
| 7 | Phosphorylation | -MSSLGASFVQIKFD -CCCCCCCEEEEEEC | 20873877 | ||
| 34 | Ubiquitination | FGSVYRAKWISQDKE CHHHHHHEECCCCHH | - | ||
| 52 | 2-Hydroxyisobutyrylation | KKLLKIEKEAEILSV HHHHHHHHHHHHHHH | - | ||
| 52 | Ubiquitination | KKLLKIEKEAEILSV HHHHHHHHHHHHHHH | - | ||
| 78 | Phosphorylation | VILEPPNYGIVTEYA EEECCCCCCEEECCC | - | ||
| 84 | Phosphorylation | NYGIVTEYASLGSLY CCCEEECCCCHHHHH | - | ||
| 93 | Phosphorylation | SLGSLYDYINSNRSE CHHHHHHHHHCCCCC | - | ||
| 99 | Phosphorylation | DYINSNRSEEMDMDH HHHHCCCCCCCCHHH | 23403867 | ||
| 109 | Phosphorylation | MDMDHIMTWATDVAK CCHHHHHHHHHHHHH | 23403867 | ||
| 116 | Acetylation | TWATDVAKGMHYLHM HHHHHHHHCCHHEEE | 7696121 | ||
| 118 | Sulfoxidation | ATDVAKGMHYLHMEA HHHHHHCCHHEEECC | 30846556 | ||
| 120 | Phosphorylation | DVAKGMHYLHMEAPV HHHHCCHHEEECCCE | 20068231 | ||
| 123 | Sulfoxidation | KGMHYLHMEAPVKVI HCCHHEEECCCEEEE | 30846556 | ||
| 128 | Ubiquitination | LHMEAPVKVIHRDLK EEECCCEEEEECCCC | - | ||
| 136 | Phosphorylation | VIHRDLKSRNVVIAA EEECCCCCCCEEEEC | 20068231 | ||
| 155 | Phosphorylation | KICDFGASRFHNHTT EECCCCCHHCCCCCC | 19060867 | ||
| 161 | Phosphorylation | ASRFHNHTTHMSLVG CHHCCCCCCCHHHEE | 15342622 | ||
| 162 | Phosphorylation | SRFHNHTTHMSLVGT HHCCCCCCCHHHEEC | 15342622 | ||
| 165 | Phosphorylation | HNHTTHMSLVGTFPW CCCCCCHHHEECCCC | 15342622 | ||
| 248 | Ubiquitination | QCWEADAKKRPSFKQ HHHHHHHHHCCCHHH | - | ||
| 258 | Phosphorylation | PSFKQIISILESMSN CCHHHHHHHHHHCCC | 27080861 | ||
| 262 | Phosphorylation | QIISILESMSNDTSL HHHHHHHHCCCCCCC | 27080861 | ||
| 264 | Phosphorylation | ISILESMSNDTSLPD HHHHHHCCCCCCCCH | 20873877 | ||
| 267 | Phosphorylation | LESMSNDTSLPDKCN HHHCCCCCCCCHHHH | 20873877 | ||
| 268 | Phosphorylation | ESMSNDTSLPDKCNS HHCCCCCCCCHHHHH | 21082442 | ||
| 272 | Ubiquitination | NDTSLPDKCNSFLHN CCCCCCHHHHHHHCC | - | ||
| 275 | Phosphorylation | SLPDKCNSFLHNKAE CCCHHHHHHHCCCCH | 25159151 | ||
| 275 (in isoform 3) | Phosphorylation | - | 29743597 | ||
| 302 | Phosphorylation | KKLERDLSFKEQELK HHHHHHCCHHHHHHH | 21712546 | ||
| 304 | Ubiquitination | LERDLSFKEQELKER HHHHCCHHHHHHHHH | - | ||
| 304 (in isoform 2) | Ubiquitination | - | - | ||
| 309 | Ubiquitination | SFKEQELKERERRLK CHHHHHHHHHHHHHH | - | ||
| 309 (in isoform 2) | Ubiquitination | - | - | ||
| 316 | Ubiquitination | KERERRLKMWEQKLT HHHHHHHHHHHHHHH | - | ||
| 321 | Ubiquitination | RLKMWEQKLTEQSNT HHHHHHHHHHHCCCC | - | ||
| 321 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 323 (in isoform 2) | Phosphorylation | - | 27251275 | ||
| 326 | Phosphorylation | EQKLTEQSNTPLLPS HHHHHHCCCCCCCCC | 18691976 | ||
| 326 (in isoform 2) | Phosphorylation | - | 22199227 | ||
| 328 | Phosphorylation | KLTEQSNTPLLPSFE HHHHCCCCCCCCCEE | 18691976 | ||
| 328 (in isoform 2) | Phosphorylation | - | 25159151 | ||
| 339 (in isoform 2) | Phosphorylation | - | 19369195 | ||
| 342 (in isoform 2) | Phosphorylation | - | 28796482 | ||
| 343 (in isoform 2) | Phosphorylation | - | 28796482 | ||
| 346 (in isoform 2) | Phosphorylation | - | 28796482 | ||
| 348 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 351 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 353 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 354 | Acetylation | WVQQLVRKGDSSAEM HHHHHHHCCCCCHHH | 11794131 | ||
| 357 | Phosphorylation | QLVRKGDSSAEMSVY HHHHCCCCCHHHHHH | 18691976 | ||
| 357 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 358 | Phosphorylation | LVRKGDSSAEMSVYA HHHCCCCCHHHHHHH | 29523821 | ||
| 361 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 362 | Phosphorylation | GDSSAEMSVYASLFK CCCCHHHHHHHHHHH | 29523821 | ||
| 363 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 364 | Phosphorylation | SSAEMSVYASLFKEN CCHHHHHHHHHHHHC | 29523821 | ||
| 364 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 366 | Phosphorylation | AEMSVYASLFKENNI HHHHHHHHHHHHCCC | 29523821 | ||
| 369 | Acetylation | SVYASLFKENNITGK HHHHHHHHHCCCCCC | 11794139 | ||
| 374 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 376 | Acetylation | KENNITGKRLLLLEE HHCCCCCCEEEEEEH | 19823749 | ||
| 388 (in isoform 2) | Phosphorylation | - | 24043423 | ||
| 401 | Ubiquitination | KGHIIHFKSAIEKLT CCCEEEHHHHHHHHC | - | ||
| 429 (in isoform 2) | Phosphorylation | - | 11042189 | ||
| 434 (in isoform 2) | Phosphorylation | - | 17192257 | ||
| 454 (in isoform 2) | Phosphorylation | - | 17192257 | ||
| 507 | Phosphorylation | WIVGIAKSQTVECTV EEEEEECCCEEEEEE | 23312004 | ||
| 509 | Phosphorylation | VGIAKSQTVECTVTY EEEECCCEEEEEEEE | 23312004 | ||
| 513 | Phosphorylation | KSQTVECTVTYESDV CCCEEEEEEEEECCC | 23312004 | ||
| 515 | Phosphorylation | QTVECTVTYESDVRT CEEEEEEEEECCCCC | 23312004 | ||
| 516 | Phosphorylation | TVECTVTYESDVRTP EEEEEEEEECCCCCC | 23312004 | ||
| 518 | Phosphorylation | ECTVTYESDVRTPKS EEEEEEECCCCCCCC | 23312004 | ||
| 522 | Phosphorylation | TYESDVRTPKSTKHV EEECCCCCCCCCCCE | 25627689 | ||
| 538 | Acetylation | SIQWSRTKPQDEVKA EEEECCCCCHHHHHH | 19816319 | ||
| 544 | Acetylation | TKPQDEVKAVQLAIQ CCCHHHHHHHHHHHH | 19816325 | ||
| 552 | Phosphorylation | AVQLAIQTLFTNSDG HHHHHHHHHHHCCCC | 27080861 | ||
| 555 | Phosphorylation | LAIQTLFTNSDGNPG HHHHHHHHCCCCCCC | 27080861 | ||
| 557 | Phosphorylation | IQTLFTNSDGNPGSR HHHHHHCCCCCCCCC | 22617229 | ||
| 563 | Phosphorylation | NSDGNPGSRSDSSAD CCCCCCCCCCCCCCC | 28102081 | ||
| 565 | Phosphorylation | DGNPGSRSDSSADCQ CCCCCCCCCCCCCCH | 23927012 | ||
| 567 | Phosphorylation | NPGSRSDSSADCQWL CCCCCCCCCCCCHHH | 23927012 | ||
| 568 | Phosphorylation | PGSRSDSSADCQWLD CCCCCCCCCCCHHHH | 23927012 | ||
| 576 | Phosphorylation | ADCQWLDTLRMRQIA CCCHHHHHHHHHHHH | 22322096 | ||
| 584 | Phosphorylation | LRMRQIASNTSLQRS HHHHHHHHCCCCHHH | 30266825 | ||
| 586 | Phosphorylation | MRQIASNTSLQRSQS HHHHHHCCCCHHHHC | 30266825 | ||
| 587 | Phosphorylation | RQIASNTSLQRSQSN HHHHHCCCCHHHHCC | 30266825 | ||
| 591 | Phosphorylation | SNTSLQRSQSNPILG HCCCCHHHHCCCCCC | 22322096 | ||
| 593 | Phosphorylation | TSLQRSQSNPILGSP CCCHHHHCCCCCCCC | 23927012 | ||
| 599 | Phosphorylation | QSNPILGSPFFSHFD HCCCCCCCCCHHCCC | 23927012 | ||
| 603 | Phosphorylation | ILGSPFFSHFDGQDS CCCCCCHHCCCCCCC | 28450419 | ||
| 610 | Phosphorylation | SHFDGQDSYAAAVRR HCCCCCCCHHHHHCC | 22322096 | ||
| 611 | Phosphorylation | HFDGQDSYAAAVRRP CCCCCCCHHHHHCCC | 28450419 | ||
| 623 | Acetylation | RRPQVPIKYQQITPV CCCCCCCEEEEECCC | 25953088 | ||
| 624 | Phosphorylation | RPQVPIKYQQITPVN CCCCCCEEEEECCCC | 28796482 | ||
| 628 | Phosphorylation | PIKYQQITPVNQSRS CCEEEEECCCCCCCC | 25159151 | ||
| 633 | Phosphorylation | QITPVNQSRSSSPTQ EECCCCCCCCCCCCC | 29255136 | ||
| 635 | Phosphorylation | TPVNQSRSSSPTQYG CCCCCCCCCCCCCCC | 30266825 | ||
| 636 | Phosphorylation | PVNQSRSSSPTQYGL CCCCCCCCCCCCCCC | 23927012 | ||
| 637 | Phosphorylation | VNQSRSSSPTQYGLT CCCCCCCCCCCCCCC | 25159151 | ||
| 639 | Phosphorylation | QSRSSSPTQYGLTKN CCCCCCCCCCCCCCC | 22617229 | ||
| 641 | Phosphorylation | RSSSPTQYGLTKNFS CCCCCCCCCCCCCCC | 23927012 | ||
| 644 | Phosphorylation | SPTQYGLTKNFSSLH CCCCCCCCCCCCCCE | 23927012 | ||
| 648 | Phosphorylation | YGLTKNFSSLHLNSR CCCCCCCCCCEECCC | 23401153 | ||
| 649 | Phosphorylation | GLTKNFSSLHLNSRD CCCCCCCCCEECCCC | 23401153 | ||
| 654 | Phosphorylation | FSSLHLNSRDSGFSS CCCCEECCCCCCCCC | 23403867 | ||
| 660 | Phosphorylation | NSRDSGFSSGNTDTS CCCCCCCCCCCCCCC | 25159151 | ||
| 661 | Phosphorylation | SRDSGFSSGNTDTSS CCCCCCCCCCCCCCC | 25159151 | ||
| 664 | Phosphorylation | SGFSSGNTDTSSERG CCCCCCCCCCCCCCC | 27251275 | ||
| 666 | Phosphorylation | FSSGNTDTSSERGRY CCCCCCCCCCCCCCC | 25159151 | ||
| 667 | Phosphorylation | SSGNTDTSSERGRYS CCCCCCCCCCCCCCC | 25159151 | ||
| 668 | Phosphorylation | SGNTDTSSERGRYSD CCCCCCCCCCCCCCC | 25262027 | ||
| 670 | Methylation | NTDTSSERGRYSDRS CCCCCCCCCCCCCCC | 30761577 | ||
| 673 | Phosphorylation | TSSERGRYSDRSRNK CCCCCCCCCCCCCCC | - | ||
| 674 | Phosphorylation | SSERGRYSDRSRNKY CCCCCCCCCCCCCCC | - | ||
| 683 | Dimethylation | RSRNKYGRGSISLNS CCCCCCCCCCCCCCC | - | ||
| 683 | Methylation | RSRNKYGRGSISLNS CCCCCCCCCCCCCCC | 16305413 | ||
| 685 | Phosphorylation | RNKYGRGSISLNSSP CCCCCCCCCCCCCCC | 22167270 | ||
| 687 | Phosphorylation | KYGRGSISLNSSPRG CCCCCCCCCCCCCCC | 22167270 | ||
| 690 | Phosphorylation | RGSISLNSSPRGRYS CCCCCCCCCCCCCCC | 30266825 | ||
| 691 | Phosphorylation | GSISLNSSPRGRYSG CCCCCCCCCCCCCCC | 30266825 | ||
| 693 | Dimethylation | ISLNSSPRGRYSGKS CCCCCCCCCCCCCCC | - | ||
| 693 | Methylation | ISLNSSPRGRYSGKS CCCCCCCCCCCCCCC | 82954731 | ||
| 696 | Phosphorylation | NSSPRGRYSGKSQHS CCCCCCCCCCCCCCC | 18691976 | ||
| 704 | Phosphorylation | SGKSQHSTPSRGRYP CCCCCCCCCCCCCCC | - | ||
| 707 | Methylation | SQHSTPSRGRYPGKF CCCCCCCCCCCCCCE | 82954737 | ||
| 709 | Methylation | HSTPSRGRYPGKFYR CCCCCCCCCCCCEEE | 115920261 | ||
| 713 | Acetylation | SRGRYPGKFYRVSQS CCCCCCCCEEEECHH | 25953088 | ||
| 713 | Methylation | SRGRYPGKFYRVSQS CCCCCCCCEEEECHH | 115920257 | ||
| 715 | Phosphorylation | GRYPGKFYRVSQSAL CCCCCCEEEECHHHC | 20068231 | ||
| 718 | Phosphorylation | PGKFYRVSQSALNPH CCCEEEECHHHCCCC | 23927012 | ||
| 720 | Phosphorylation | KFYRVSQSALNPHQS CEEEECHHHCCCCCC | 23927012 | ||
| 727 | Phosphorylation | SALNPHQSPDFKRSP HHCCCCCCCCCCCCC | 29255136 | ||
| 733 | Phosphorylation | QSPDFKRSPRDLHQP CCCCCCCCCCCCCCC | 11836244 | ||
| 742 | Phosphorylation | RDLHQPNTIPGMPLH CCCCCCCCCCCCCCC | 28555341 | ||
| 752 | Phosphorylation | GMPLHPETDSRASEE CCCCCCCCCCCCCHH | 29523821 | ||
| 754 | Phosphorylation | PLHPETDSRASEEDS CCCCCCCCCCCHHHH | 28450419 | ||
| 757 | Phosphorylation | PETDSRASEEDSKVS CCCCCCCCHHHHCCC | 28450419 | ||
| 761 | Phosphorylation | SRASEEDSKVSEGGW CCCCHHHHCCCCCCC | 28450419 | ||
| 764 | Phosphorylation | SEEDSKVSEGGWTKV CHHHHCCCCCCCEEE | - | ||
| 769 | Phosphorylation | KVSEGGWTKVEYRKK CCCCCCCEEEEECCC | - | ||
| 770 | Ubiquitination | VSEGGWTKVEYRKKP CCCCCCEEEEECCCC | - | ||
| 781 | Phosphorylation | RKKPHRPSPAKTNKE CCCCCCCCCCCCCHH | 17192257 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of M3K20_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of M3K20_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZN567_HUMAN | ZNF567 | physical | 16189514 | |
| M3K20_HUMAN | ZAK | physical | 15485649 | |
| MP2K7_HUMAN | MAP2K7 | physical | 15465036 | |
| ZN33A_HUMAN | ZNF33A | physical | 12535642 | |
| M3K20_HUMAN | ZAK | physical | 10924358 | |
| MIDN_HUMAN | MIDN | physical | 21900206 | |
| ZN593_HUMAN | ZNF593 | physical | 21900206 | |
| RBX1_HUMAN | RBX1 | physical | 21900206 | |
| EM55_HUMAN | MPP1 | physical | 21900206 | |
| SNF5_HUMAN | SMARCB1 | physical | 21900206 | |
| EZH2_HUMAN | EZH2 | physical | 21900206 | |
| VP33B_HUMAN | VPS33B | physical | 21900206 | |
| U119A_HUMAN | UNC119 | physical | 21900206 | |
| DDAH2_HUMAN | DDAH2 | physical | 21900206 | |
| ZN775_HUMAN | ZNF775 | physical | 21900206 | |
| ZN746_HUMAN | ZNF746 | physical | 21900206 | |
| CCD69_HUMAN | CCDC69 | physical | 21900206 | |
| RN19A_HUMAN | RNF19A | physical | 21900206 | |
| DPYL1_HUMAN | CRMP1 | physical | 21900206 | |
| ITSN1_HUMAN | ITSN1 | physical | 21900206 | |
| ZFP2_HUMAN | ZFP2 | physical | 25416956 | |
| ZN567_HUMAN | ZNF567 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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