CCD69_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD69_HUMAN
• UniProt AC: A6NI79
• Protein Name: Coiled-coil domain-containing protein 69 {ECO:0000305}
• Gene Name: CCDC69 {ECO:0000312|HGNC:HGNC:24487}
• Organism: Homo sapiens (Human).
• Sequence Length: 296
• Subcellular Localization: Cytoplasm, cytoskeleton, spindle . Midbody . During early anaphase, localizes along overlapping interpolar microtubules between the separating chromosomes. During late anaphase, localizes to the center of spindle midzone. Concentrated at the midbody
• Protein Description: May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone..
• Protein Sequence: MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCRHSRLS ------CCCCCCCCC	19.71	-
9	Phosphorylation	GCRHSRLSSCKPPKK CCCCCCCCCCCCCCC	32.36	23403867
10	Phosphorylation	CRHSRLSSCKPPKKK CCCCCCCCCCCCCCC	30.65	23403867
122	Phosphorylation	EKEALTHSFREASST HHHHHHHHHHHCCHH	22.29	24275569
154	Phosphorylation	KMKRVEESILSRNYK HHHHHHHHHHCCHHH	18.47	24719451
157	Phosphorylation	RVEESILSRNYKKHI HHHHHHHCCHHHHHH	19.46	24719451
204	Phosphorylation	RRLILMETVKEKNLI HHHHHHHHHHHHCCH	23.94	-
241	Phosphorylation	VVLSRQLSEDLLLTR HHHHHHCCCCHHHCH	22.26	23403867
270	Phosphorylation	QEKEELLYRVLGANA HHHHHHHHHHHCCCC	15.99	-
287	Phosphorylation	AFPLAPVTPTEVSFL CCCCCCCCCCEEEEC	24.35	24719451
289	Phosphorylation	PLAPVTPTEVSFLAT CCCCCCCCEEEECCC	39.39	27251275
292	Phosphorylation	PVTPTEVSFLAT--- CCCCCEEEECCC---	14.33	27251275
296	Phosphorylation	TEVSFLAT------- CEEEECCC-------	41.09	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD69_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD69_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RMI1_HUMAN	RMI1	physical	28514442
TOP3A_HUMAN	TOP3A	physical	28514442
MMAD_HUMAN	MMADHC	physical	28514442
PSMG4_HUMAN	PSMG4	physical	28514442
NUDT8_HUMAN	NUDT8	physical	28514442
PSMG3_HUMAN	PSMG3	physical	28514442
F192A_HUMAN	FAM192A	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
GGPPS_HUMAN	GGPS1	physical	28514442
RMI2_HUMAN	RMI2	physical	28514442
PSME3_HUMAN	PSME3	physical	28514442
ASH2L_HUMAN	ASH2L	physical	28514442
EPDR1_HUMAN	EPDR1	physical	28514442
GRN_HUMAN	GRN	physical	28514442
MTA2_HUMAN	MTA2	physical	28514442
MPPB_HUMAN	PMPCB	physical	28514442
MPPA_HUMAN	PMPCA	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.