ZN33A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN33A_HUMAN
• UniProt AC: Q06730
• Protein Name: Zinc finger protein 33A
• Gene Name: ZNF33A
• Organism: Homo sapiens (Human).
• Sequence Length: 810
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MNKVEQKSQESVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCVHKPEVIFRLQQGEEPWKQEEEFPSQSFPVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGDVIGIPFNVDVSSFPSRKMFCQCDSCGMSFNTVSELVISKINYLGKKSDEFNACGKLLLNIKHDETHTQEKNEVLKNRNTLSHHEETLQHEKIQTLEHNFEYSICQETLLEKAVFNTQKRENAEENNCDYNEFGRTLCDSSSLLFHQISPSRDNHYEFSDCEKFLCVKSTLSKPHGVSMKHYDCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQRVHTGQKPFQCNECEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGKTFCQKSDLTKHQRTHTGLKPYECYECGKSFRVTSHLKVHQRTHTGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKSLLTRHQIIHTGWKPYECYECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGKAFCHKSALIVHQRTHTQEKPYKCNECGKSFCVKSGLIFHERKHTGEKPYECNECGKFFRHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSELAQHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRRHIGENLMNEMDIRNFQPQVSLHNASEYSHCGESPDDILNVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Ubiquitination	-----MNKVEQKSQE -----CCHHCHHHHC	45.94	-
7	Ubiquitination	-MNKVEQKSQESVSF -CCHHCHHHHCCCCC	40.37	-
8	Phosphorylation	MNKVEQKSQESVSFK CCHHCHHHHCCCCCC	38.58	29083192
11	Phosphorylation	VEQKSQESVSFKDVT HCHHHHCCCCCCCEE	18.54	29083192
13	Phosphorylation	QKSQESVSFKDVTVG HHHHCCCCCCCEEEC	35.54	24719451
15	Acetylation	SQESVSFKDVTVGFT HHCCCCCCCEEECCC	43.73	12437799
18	Phosphorylation	SVSFKDVTVGFTQEE CCCCCCEEECCCHHH	25.66	25002506
22	Phosphorylation	KDVTVGFTQEEWQHL CCEEECCCHHHHHHC	29.19	25002506
32	Phosphorylation	EWQHLDPSQRALYRD HHHHCCHHHHHHHHH	31.78	25002506
165	Ubiquitination	KINYLGKKSDEFNAC HHHHCCCCCHHCCHH	62.43	-
166	Phosphorylation	INYLGKKSDEFNACG HHHCCCCCHHCCHHH	45.95	28555341
172	Ubiquitination	KSDEFNACGKLLLNI CCHHCCHHHHHHHHC	5.32	-
180	Sumoylation	GKLLLNIKHDETHTQ HHHHHHCCCCCCCHH	43.88	-
180	Sumoylation	GKLLLNIKHDETHTQ HHHHHHCCCCCCCHH	43.88	28112733
180	Ubiquitination	GKLLLNIKHDETHTQ HHHHHHCCCCCCCHH	43.88	-
184	Phosphorylation	LNIKHDETHTQEKNE HHCCCCCCCHHHHHH	35.96	30624053
186	Phosphorylation	IKHDETHTQEKNEVL CCCCCCCHHHHHHHH	45.93	30624053
189	Ubiquitination	DETHTQEKNEVLKNR CCCCHHHHHHHHHCC	48.90	-
194	Ubiquitination	QEKNEVLKNRNTLSH HHHHHHHHCCCCCCC	60.06	-
196	Ubiquitination	KNEVLKNRNTLSHHE HHHHHHCCCCCCCHH	35.60	-
201	Ubiquitination	KNRNTLSHHEETLQH HCCCCCCCHHHHHHH	35.18	-
237	Sumoylation	KAVFNTQKRENAEEN HHHHCHHHHHCHHHC	60.69	-
237	Sumoylation	KAVFNTQKRENAEEN HHHHCHHHHHCHHHC	60.69	28112733
237	Ubiquitination	KAVFNTQKRENAEEN HHHHCHHHHHCHHHC	60.69	-
244	Ubiquitination	KRENAEENNCDYNEF HHHCHHHCCCCHHHH	46.03	-
258	Phosphorylation	FGRTLCDSSSLLFHQ HHHHHHCHHHCEEEE	22.34	23312004
259	Phosphorylation	GRTLCDSSSLLFHQI HHHHHCHHHCEEEEC	16.26	23312004
260	Phosphorylation	RTLCDSSSLLFHQIS HHHHCHHHCEEEECC	32.80	23312004
267	Phosphorylation	SLLFHQISPSRDNHY HCEEEECCCCCCCCC	15.39	23401153
268	Phosphorylation	LLFHQISPSRDNHYE CEEEECCCCCCCCCC	34.70	24719451
269	Phosphorylation	LFHQISPSRDNHYEF EEEECCCCCCCCCCC	45.54	25849741
281	Ubiquitination	YEFSDCEKFLCVKST CCCCCCCEEEEEECC	50.39	-
282	Phosphorylation	EFSDCEKFLCVKSTL CCCCCCEEEEEECCC	2.74	27251275
286	Ubiquitination	CEKFLCVKSTLSKPH CCEEEEEECCCCCCC	36.40	-
289	Phosphorylation	FLCVKSTLSKPHGVS EEEEECCCCCCCCCC	8.82	27251275
312	Ubiquitination	SGNNFRRKLCLSHLQ CCCCHHHHHHHHHHH	39.02	-
312	Sumoylation	SGNNFRRKLCLSHLQ CCCCHHHHHHHHHHH	39.02	28112733
335	Ubiquitination	FECNECGKAFWEKSH EEECHHHHHHHHHHC	52.66	-
340	Sumoylation	CGKAFWEKSHLTRHQ HHHHHHHHHCCCCHH	33.50	-
340	Sumoylation	CGKAFWEKSHLTRHQ HHHHHHHHHCCCCHH	33.50	-
340	Ubiquitination	CGKAFWEKSHLTRHQ HHHHHHHHHCCCCHH	33.50	-
342	Ubiquitination	KAFWEKSHLTRHQRV HHHHHHHCCCCHHHH	42.14	-
347	Ubiquitination	KSHLTRHQRVHTGQK HHCCCCHHHHHCCCC	45.89	-
351	Phosphorylation	TRHQRVHTGQKPFQC CCHHHHHCCCCCCCC	38.15	21712546
354	Sumoylation	QRVHTGQKPFQCNEC HHHHCCCCCCCCCHH	49.50	-
354	Sumoylation	QRVHTGQKPFQCNEC HHHHCCCCCCCCCHH	49.50	-
354	Ubiquitination	QRVHTGQKPFQCNEC HHHHCCCCCCCCCHH	49.50	-
363	Ubiquitination	FQCNECEKAFWDKSN CCCCHHHHHHCCCCC	61.62	-
368	Sumoylation	CEKAFWDKSNLTKHQ HHHHHCCCCCCCCCC	31.66	-
368	Sumoylation	CEKAFWDKSNLTKHQ HHHHHCCCCCCCCCC	31.66	-
368	Ubiquitination	CEKAFWDKSNLTKHQ HHHHHCCCCCCCCCC	31.66	-
370	Ubiquitination	KAFWDKSNLTKHQRS HHHCCCCCCCCCCCC	58.43	-
375	Ubiquitination	KSNLTKHQRSHTGEK CCCCCCCCCCCCCCC	50.56	-
382	Ubiquitination	QRSHTGEKPFECNEC CCCCCCCCCEECCCC	57.25	-
382	Acetylation	QRSHTGEKPFECNEC CCCCCCCCCEECCCC	57.25	20167786
389	Ubiquitination	KPFECNECGKAFSHK CCEECCCCCCCCCCC	4.16	-
405	Phosphorylation	ALTLHQRTHTGEKPY CEEEECCCCCCCCCE	19.74	-
407	Phosphorylation	TLHQRTHTGEKPYQC EEECCCCCCCCCEEC	46.56	-
410	Ubiquitination	QRTHTGEKPYQCNAC CCCCCCCCCEECCCC	50.82	-
417	Ubiquitination	KPYQCNACGKTFCQK CCEECCCCCCEEECH	3.41	-
424	Ubiquitination	CGKTFCQKSDLTKHQ CCCEEECHHCCCCCC	47.31	-
425	Phosphorylation	GKTFCQKSDLTKHQR CCEEECHHCCCCCCC	16.39	29978859
428	Phosphorylation	FCQKSDLTKHQRTHT EECHHCCCCCCCCCC	31.32	29978859
431	Ubiquitination	KSDLTKHQRTHTGLK HHCCCCCCCCCCCCC	54.23	-
433	Phosphorylation	DLTKHQRTHTGLKPY CCCCCCCCCCCCCCE	19.74	29978859
435	Phosphorylation	TKHQRTHTGLKPYEC CCCCCCCCCCCCEEE	43.53	29978859
448	Phosphorylation	ECYECGKSFRVTSHL EEEECCCEEEEEEEE	11.99	-
456	Ubiquitination	FRVTSHLKVHQRTHT EEEEEEEEEEECCCC	32.04	-
456	Sumoylation	FRVTSHLKVHQRTHT EEEEEEEEEEECCCC	32.04	28112733
461	Phosphorylation	HLKVHQRTHTGEKPF EEEEEECCCCCCCCE	19.74	-
463	Phosphorylation	KVHQRTHTGEKPFEC EEEECCCCCCCCEEE	46.56	-
466	Ubiquitination	QRTHTGEKPFECLEC ECCCCCCCCEEEECC	57.25	-
473	Ubiquitination	KPFECLECGKSFSEK CCEEEECCCCCCCCC	5.55	-
480	Sumoylation	CGKSFSEKSNLTQHQ CCCCCCCCCCCCCCC	43.37	-
480	Sumoylation	CGKSFSEKSNLTQHQ CCCCCCCCCCCCCCC	43.37	-
480	Ubiquitination	CGKSFSEKSNLTQHQ CCCCCCCCCCCCCCC	43.37	-
508	Sumoylation	CGKTFYHKSLLTRHQ CCCCEECHHHHHHHH	31.27	-
508	Sumoylation	CGKTFYHKSLLTRHQ CCCCEECHHHHHHHH	31.27	-
509	Phosphorylation	GKTFYHKSLLTRHQI CCCEECHHHHHHHHE	18.46	24719451
510	Phosphorylation	KTFYHKSLLTRHQII CCEECHHHHHHHHEE	7.26	24719451
536	Sumoylation	CGKTFCLKSDLTVHQ CCCEEEEECCCEEEE	43.00	-
536	Sumoylation	CGKTFCLKSDLTVHQ CCCEEEEECCCEEEE	43.00	-
545	Phosphorylation	DLTVHQRTHTGQKPF CCEEEECCCCCCCCC	19.74	28258704
573	Phosphorylation	TLSQHYRTHTGEKPY HHHHHHHHCCCCCCE	19.34	-
575	Phosphorylation	SQHYRTHTGEKPYEC HHHHHHCCCCCCEEE	46.56	-
590	Phosphorylation	HECGKIFYNKSYLTK CCCCCEEECHHHHHC	25.75	-
592	Sumoylation	CGKIFYNKSYLTKHN CCCEEECHHHHHCCC	29.15	-
592	Sumoylation	CGKIFYNKSYLTKHN CCCEEECHHHHHCCC	29.15	-
594	Phosphorylation	KIFYNKSYLTKHNRT CEEECHHHHHCCCCC	21.72	-
601	Phosphorylation	YLTKHNRTHTGEKPY HHHCCCCCCCCCCCC	29.16	28348404
603	Phosphorylation	TKHNRTHTGEKPYEC HCCCCCCCCCCCCCC	46.56	29496963
606	Ubiquitination	NRTHTGEKPYECNEC CCCCCCCCCCCCCHH	55.00	-
620	Sumoylation	CGKAFYQKSQLTQHQ HHHHHHHHHCCCCCC	28.88	-
620	Sumoylation	CGKAFYQKSQLTQHQ HHHHHHHHHCCCCCC	28.88	-
620	Ubiquitination	CGKAFYQKSQLTQHQ HHHHHHHHHCCCCCC	28.88	-
627	Ubiquitination	KSQLTQHQRIHIGEK HHCCCCCCCEECCCC	35.88	-
634	Ubiquitination	QRIHIGEKPYKCNEC CCEECCCCCCCCCCC	48.73	-
637	Sumoylation	HIGEKPYKCNECGKA ECCCCCCCCCCCCCC	38.83	-
637	Sumoylation	HIGEKPYKCNECGKA ECCCCCCCCCCCCCC	38.83	-
665	Sumoylation	HTQEKPYKCNECGKS CCCCCCEECCCCCCE	38.83	-
665	Sumoylation	HTQEKPYKCNECGKS CCCCCCEECCCCCCE	38.83	-
672	Phosphorylation	KCNECGKSFCVKSGL ECCCCCCEEEEECCC	14.79	30108239
676	Sumoylation	CGKSFCVKSGLIFHE CCCEEEEECCCEEEC	39.73	-
676	Sumoylation	CGKSFCVKSGLIFHE CCCEEEEECCCEEEC	39.73	28112733
687	Phosphorylation	IFHERKHTGEKPYEC EEECCCCCCCCCEEC	50.50	23532336
690	Ubiquitination	ERKHTGEKPYECNEC CCCCCCCCCEECCCC	55.00	-
699	Sumoylation	YECNECGKFFRHKSS EECCCCCCEEECCCC	53.65	-
699	Ubiquitination	YECNECGKFFRHKSS EECCCCCCEEECCCC	53.65	-
699	Sumoylation	YECNECGKFFRHKSS EECCCCCCEEECCCC	53.65	-
727	Ubiquitination	CQCNECGKIFYRKSE CCCCCCCCEEEEHHH	41.10	-
732	Sumoylation	CGKIFYRKSELAQHQ CCCEEEEHHHHHHHH	36.58	28112733
734	Ubiquitination	KIFYRKSELAQHQRS CEEEEHHHHHHHHHH	51.68	-
760	Sumoylation	CRKTFSQKSNLIVHQ CCCCCCCCCCEEEEE	39.86	-
760	Sumoylation	CRKTFSQKSNLIVHQ CCCCCCCCCCEEEEE	39.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN33A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN33A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN33A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K20_HUMAN	ZAK	physical	12535642

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.
PubMed: 18220336