MIDN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIDN_HUMAN
• UniProt AC: Q504T8
• Protein Name: Midnolin
• Gene Name: MIDN
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Nucleus, nucleolus . Nucleus . Cytoplasm, cytosol . Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (P
• Protein Description: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion..
• Protein Sequence: MEPQPGGARSCRRGAPGGACELGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTLALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAARGDPSIASPVSSPCRPVSSAARVPPVPTSPSPASPSPITAGSFRSHAASTTCPEQMDCSPTASSSASPGASTTSTPGASPAPRSRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQGMPPSLAQLRCHAQCSPASPAPDLAPRTTSCEKLTAAPSASLLQGQSQIRMCKPPGDRLRQTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGRSDSSSSGGGGSPSEASGLGLDFEDSVWKPEVNPDIKSEFVVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Ubiquitination	ERLALLHKDTRLSSG HHHHHHCCCCCCCCC	61.84	29967540
84	Ubiquitination	DTRLSSGKLQEFGVG CCCCCCCCCEEECCC	49.28	22817900
134	Phosphorylation	TQVSDFLSGRSPLTL HHHHHHHCCCCCCEE	31.96	24719451
183	Phosphorylation	AAARGDPSIASPVSS HHHCCCCCCCCCCCC	35.21	23312004
186	Phosphorylation	RGDPSIASPVSSPCR CCCCCCCCCCCCCCC	24.94	21712546
189	Phosphorylation	PSIASPVSSPCRPVS CCCCCCCCCCCCCCC	31.76	23312004
190	Phosphorylation	SIASPVSSPCRPVSS CCCCCCCCCCCCCCC	28.40	21712546
196	Phosphorylation	SSPCRPVSSAARVPP CCCCCCCCCCCCCCC	19.55	22817900
197	Phosphorylation	SPCRPVSSAARVPPV CCCCCCCCCCCCCCC	26.61	23312004
206	Phosphorylation	ARVPPVPTSPSPASP CCCCCCCCCCCCCCC	54.20	29978859
207	Phosphorylation	RVPPVPTSPSPASPS CCCCCCCCCCCCCCC	19.81	27050516
209	Phosphorylation	PPVPTSPSPASPSPI CCCCCCCCCCCCCCC	32.63	28464451
212	Phosphorylation	PTSPSPASPSPITAG CCCCCCCCCCCCCCC	29.33	29978859
214	Phosphorylation	SPSPASPSPITAGSF CCCCCCCCCCCCCCH	26.83	29978859
217	Phosphorylation	PASPSPITAGSFRSH CCCCCCCCCCCHHCC	28.49	22817900
241	Phosphorylation	MDCSPTASSSASPGA CCCCCCCCCCCCCCC	27.57	22210691
305	Phosphorylation	RPRRDIGTILQILND CCCCHHHHHHHHHHH	20.88	-
337	Phosphorylation	LRCHAQCSPASPAPD HHHHCCCCCCCCCCC	16.06	27251275
340	Phosphorylation	HAQCSPASPAPDLAP HCCCCCCCCCCCCCC	25.61	27251275
354	Ubiquitination	PRTTSCEKLTAAPSA CCCCCHHHCCCCCCH	56.30	21963094
360	Phosphorylation	EKLTAAPSASLLQGQ HHCCCCCCHHHHCCC	26.26	-
396	Ubiquitination	RCKVERLQLLLQQKR HHHHHHHHHHHHHHH	35.96	21963094
397	Ubiquitination	CKVERLQLLLQQKRL HHHHHHHHHHHHHHH	6.45	21963094
402	Ubiquitination	LQLLLQQKRLRRKAR HHHHHHHHHHHHHHH	40.20	29967540
419	Phosphorylation	ARGPYHWSPSRKAGR HCCCCCCCCCCCCCC	10.33	23898821
462	Sumoylation	PEVNPDIKSEFVVA- CCCCCCCCCCCCCC-	51.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIDN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIDN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIDN_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MIDN_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.