| UniProt ID | CSCL2_HUMAN | |
|---|---|---|
| UniProt AC | Q5T3F8 | |
| Protein Name | CSC1-like protein 2 | |
| Gene Name | TMEM63B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 832 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Acts as an osmosensitive calcium-permeable cation channel.. | |
| Protein Sequence | MLPFLLATLGTTALNNSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKVAWDYGRLALVTDADRLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLTAIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTIANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHFEEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVRGCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCRGEPRPSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIIITTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYTFLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDLLRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLMYMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFVVLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSEVDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MLPFLLATLGTTALN CCHHHHHHHCCCHHC | 24043423 | ||
| 11 | Phosphorylation | FLLATLGTTALNNSN HHHHHHCCCHHCCCC | 24043423 | ||
| 12 | Phosphorylation | LLATLGTTALNNSNP HHHHHCCCHHCCCCH | 24043423 | ||
| 17 | Phosphorylation | GTTALNNSNPKDYCY CCCHHCCCCHHHCCH | 24043423 | ||
| 22 | Phosphorylation | NNSNPKDYCYSARIR CCCCHHHCCHHHHCC | 24043423 | ||
| 24 | Phosphorylation | SNPKDYCYSARIRST CCHHHCCHHHHCCCH | 24043423 | ||
| 25 | Phosphorylation | NPKDYCYSARIRSTV CHHHCCHHHHCCCHH | 24043423 | ||
| 93 | Phosphorylation | RDRVEQEYVASAMHG HHHHHHHHHHHHHCC | 21945579 | ||
| 96 | Phosphorylation | VEQEYVASAMHGDSH HHHHHHHHHHCCCCC | 21945579 | ||
| 102 | Phosphorylation | ASAMHGDSHDRYERL HHHHCCCCCHHHHHH | 21945579 | ||
| 106 | Phosphorylation | HGDSHDRYERLTSVS CCCCCHHHHHHHHCC | 21945579 | ||
| 110 | Phosphorylation | HDRYERLTSVSSSVD CHHHHHHHHCCCCCC | 30266825 | ||
| 111 | Phosphorylation | DRYERLTSVSSSVDF HHHHHHHHCCCCCCC | 30266825 | ||
| 113 | Phosphorylation | YERLTSVSSSVDFDQ HHHHHHCCCCCCCCC | 30266825 | ||
| 114 | Phosphorylation | ERLTSVSSSVDFDQR HHHHHCCCCCCCCCC | 30266825 | ||
| 115 | Phosphorylation | RLTSVSSSVDFDQRD HHHHCCCCCCCCCCC | 30266825 | ||
| 126 | S-palmitoylation | DQRDNGFCSWLTAIF CCCCCCCCHHHHHHE | 29575903 | ||
| 153 | Phosphorylation | GDAVHYLSFQRHIIG CCHHHHHHHHHHHHH | 24719451 | ||
| 242 | Ubiquitination | DDLVKRTLFINGISK HHHHHHHHHHHHHHH | 23000965 | ||
| 244 | Ubiquitination | LVKRTLFINGISKYA HHHHHHHHHHHHHHH | 23000965 | ||
| 245 | Ubiquitination | VKRTLFINGISKYAE HHHHHHHHHHHHHHH | 21890473 | ||
| 251 | Ubiquitination | INGISKYAESEKIKK HHHHHHHHHHHHHHH | 23000965 | ||
| 253 | Ubiquitination | GISKYAESEKIKKHF HHHHHHHHHHHHHHH | 23000965 | ||
| 254 | Ubiquitination | ISKYAESEKIKKHFE HHHHHHHHHHHHHHH | 21890473 | ||
| 255 | Ubiquitination | SKYAESEKIKKHFEE HHHHHHHHHHHHHHH | 23000965 | ||
| 257 | Ubiquitination | YAESEKIKKHFEEAY HHHHHHHHHHHHHHC | 23000965 | ||
| 258 | Ubiquitination | AESEKIKKHFEEAYP HHHHHHHHHHHHHCC | 23000965 | ||
| 258 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 258 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 258 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 264 | Phosphorylation | KKHFEEAYPNCTVLE HHHHHHHCCCCEEEE | 22468782 | ||
| 264 | Ubiquitination | KKHFEEAYPNCTVLE HHHHHHHCCCCEEEE | 23000965 | ||
| 266 | Ubiquitination | HFEEAYPNCTVLEAR HHHHHCCCCEEEECC | 23000965 | ||
| 267 | Ubiquitination | FEEAYPNCTVLEARP HHHHCCCCEEEECCC | 21890473 | ||
| 268 | Phosphorylation | EEAYPNCTVLEARPC HHHCCCCEEEECCCC | 22468782 | ||
| 276 | Phosphorylation | VLEARPCYNVARLMF EEECCCCCCHHHHHH | 22468782 | ||
| 297 | Phosphorylation | KAERGKLYFTNLQSK HHHCCCEEEECCCCC | 25884760 | ||
| 337 | Phosphorylation | VEAIEYYTKLEQKLK HHHHHHHHHHHHHHH | 29759185 | ||
| 338 | Ubiquitination | EAIEYYTKLEQKLKE HHHHHHHHHHHHHHH | 29967540 | ||
| 347 | Phosphorylation | EQKLKEDYKREKEKV HHHHHHHHHHHHHHH | - | ||
| 424 | Phosphorylation | NIYWEHLSIRGFIWW CCCEECCHHHHHHHH | 24719451 | ||
| 449 | Phosphorylation | FILLFFLTTPAIIIT HHHHHHHHCCHHHHH | 24043423 | ||
| 450 | Phosphorylation | ILLFFLTTPAIIITT HHHHHHHCCHHHHHC | 24043423 | ||
| 456 | Phosphorylation | TTPAIIITTMDKFNV HCCHHHHHCHHCCCC | 24043423 | ||
| 457 | Phosphorylation | TPAIIITTMDKFNVT CCHHHHHCHHCCCCC | 24043423 | ||
| 548 | Acetylation | FRWLFDKKFLAEAAI HHHHHCHHHHHHHHH | 20167786 | ||
| 661 | Phosphorylation | LKHLVDRYNLYYAYL HHHHHHHHCHHHEEC | 25693802 | ||
| 746 | Phosphorylation | HNYKIEHTETDTVDP CCCEEEECCCCCCCC | 23312004 | ||
| 748 | Phosphorylation | YKIEHTETDTVDPRS CEEEECCCCCCCCCC | 23312004 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CSCL2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CSCL2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CSCL2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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