HLAF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HLAF_HUMAN
• UniProt AC: P30511
• Protein Name: HLA class I histocompatibility antigen, alpha chain F
• Gene Name: HLA-F
• Organism: Homo sapiens (Human).
• Sequence Length: 346
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Involved in the presentation of foreign antigens to the immune system..
• Protein Sequence: MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQRDGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAPRSLLLLLSG ---CCCHHHHHHHHH	23.47	24043423
11	Phosphorylation	RSLLLLLSGALALTD HHHHHHHHHHHHHHC	23.22	24043423
17	Phosphorylation	LSGALALTDTWAGSH HHHHHHHHCCCCCCC	26.27	24043423
19	Phosphorylation	GALALTDTWAGSHSL HHHHHHCCCCCCCCC	16.39	24043423
23	Phosphorylation	LTDTWAGSHSLRYFS HHCCCCCCCCCEEEE	11.36	24043423
25	Phosphorylation	DTWAGSHSLRYFSTA CCCCCCCCCEEEEEC	19.08	24043423
28	Phosphorylation	AGSHSLRYFSTAVSR CCCCCCEEEEECCCC	13.74	24043423
30	Phosphorylation	SHSLRYFSTAVSRPG CCCCEEEEECCCCCC	13.41	24043423
31	O-linked_Glycosylation	HSLRYFSTAVSRPGR CCCEEEEECCCCCCC	22.60	30620550
31	Phosphorylation	HSLRYFSTAVSRPGR CCCEEEEECCCCCCC	22.60	24043423
34	Phosphorylation	RYFSTAVSRPGRGEP EEEEECCCCCCCCCC	30.23	24043423
59	Phosphorylation	TQFLRFDSDAAIPRM CEEEEECCCCCCCCC	26.83	26657352
89	Ubiquitination	EWTTGYAKANAQTDR EEECCHHHCCCHHHH	33.42	21906983
106	Phosphorylation	LRNLLRRYNQSEAGS HHHHHHHHCCCCCCC	15.89	-
107	N-linked_Glycosylation	RNLLRRYNQSEAGSH HHHHHHHCCCCCCCC	36.77	UniProtKB CARBOHYD
139	Phosphorylation	RGYHQHAYDGKDYIS CCCCCCCCCCCCCEE	24.09	-
142	Ubiquitination	HQHAYDGKDYISLNE CCCCCCCCCCEECCH	44.45	21906983
180	Phosphorylation	YAEEFRTYLEGECLE HHHHHHHHHHHHHHH	9.86	-
192	Phosphorylation	CLELLRRYLENGKET HHHHHHHHHHHCHHH	16.37	28152594
197	Ubiquitination	RRYLENGKETLQRAD HHHHHHCHHHHHHCC	60.14	21890473
199	Phosphorylation	YLENGKETLQRADPP HHHHCHHHHHHCCCC	31.51	-
216	Phosphorylation	HVAHHPISDHEATLR EECCCCCCHHHHHHH	37.05	-
264	Ubiquitination	AGDGTFQKWAAVVVP CCCCCEEEEEEEEEC	34.31	2190698
298	Phosphorylation	LILRWEQSPQPTIPI EEEEEECCCCCCCCC	17.62	22210691
340	Phosphorylation	SSDRNRGSYSQAAV- CCCCCCCCCCCCCC-	20.55	30108239
341	Phosphorylation	SDRNRGSYSQAAV-- CCCCCCCCCCCCC--	13.97	28857561
342	Phosphorylation	DRNRGSYSQAAV--- CCCCCCCCCCCC---	18.29	30108239
423	Phosphorylation	------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HLAF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HLAF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HLAF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B2MG_HUMAN	B2M	physical	26186194
K1549_HUMAN	KIAA1549	physical	26186194
KDM5C_HUMAN	KDM5C	physical	26186194
KDM5C_HUMAN	KDM5C	physical	28514442
K1549_HUMAN	KIAA1549	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00344: Leprosy; Hansen disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.