dbPTM

K1549_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K1549_HUMAN
UniProt AC	Q9HCM3
Protein Name	UPF0606 protein KIAA1549
Gene Name	KIAA1549
Organism	Homo sapiens (Human).
Sequence Length	1950
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MPGARRRRRGAAMEGKPRAGVALAPGPSGRRPSARCARRRRPGLLLPGLWLLLLARPASCAPDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVATYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFHTFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSADRYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILSPVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEISETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFTPYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQSSQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALVPPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLPTELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDITVPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVPESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSELLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNSVVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVLVVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKIPSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIAMQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTASVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPASQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSRYEDYGMTPPTGPLPRPGFGPGLLQSTELVPPDPQQPQASAEAPFAARGIYSEEMPSVARPRPVGGTTGSQIQHLTQVGIASRIGAQPVEIPPSRGSQYGGPGWPSYGEDEAGRREATHMLGHQEYSSSPLFQVPRTSGREPSAPSGNLPHRGLQGPGLGYPTSSTEDLQPGHSSASLIKAIREELLRLSQKQSTVQNFHS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	VALAPGPSGRRPSAR EEECCCCCCCCCCHH	51.34	-
33	Phosphorylation	GPSGRRPSARCARRR CCCCCCCCHHHHHHC	26.91	-
177	Phosphorylation	RMVSPIQYITVSPPG CCCCCCEEEEECCCC	10.16	28464451
181	Phosphorylation	PIQYITVSPPGLPRE CCEEEEECCCCCCHH	19.41	28464451
262	Phosphorylation	TDAYSHLSSRTLPEI CHHHHHHHCCCHHHH	16.61	-
263	Phosphorylation	DAYSHLSSRTLPEIV HHHHHHHCCCHHHHH	35.33	-
459	Phosphorylation	CMTVLEESSISLMSS HHHHHHHCCHHHHHH	24.48	22210691
466	Phosphorylation	SSISLMSSVVADFSE CCHHHHHHHHCCHHH	13.47	22210691
497	Phosphorylation	IVPLSSRSMEISETS EEECCCCCEEEEECC	23.79	22468782
515	Phosphorylation	SAEVDMSSVTTTQVP EEEECCCCCCCCCCC	19.49	22468782
580	Phosphorylation	IANKNTPSLAVRDPS EECCCCCCCEECCCC	27.24	24275569
712	Phosphorylation	NTIMLLPSRSEVSPW CEEEEECCCCCCCCC	48.70	25278378
827	Phosphorylation	GHVSVLASFSKAIPT CCHHHHHHHHCCCCC	26.37	24719451
920	Phosphorylation	SAAPPLPSLRPVTAF CCCCCCCCCCCEEEE	44.70	24719451
1007	Ubiquitination	LVTSGPFVYTAISVI EECCCCCHHHHHHHH	4.70	21963094
1032	Phosphorylation	DQTPLILSVKPSFLV CCCCEEEEECHHHCC	22.54	24719451
1034	Ubiquitination	TPLILSVKPSFLVPE CCEEEEECHHHCCCC	31.41	21963094
1074	Phosphorylation	RIEKGLMTALFEVRK HHHHHHHHHHHHHHH	25.83	29514088
1086	Phosphorylation	VRKHHQGTYNLTVQI HHHHCCCCEEEEEEE	11.58	25262027
1087	Phosphorylation	RKHHQGTYNLTVQIL HHHCCCCEEEEEEEE	18.26	25262027
1090	Phosphorylation	HQGTYNLTVQILNIT CCCCEEEEEEEEEEE	13.51	25262027
1097	Phosphorylation	TVQILNITISSSRVT EEEEEEEEEECCCCC	17.46	25262027
1099	Phosphorylation	QILNITISSSRVTPR EEEEEEEECCCCCCC	17.38	24905233
1100	Phosphorylation	ILNITISSSRVTPRR EEEEEEECCCCCCCC	20.50	24905233
1101	Phosphorylation	LNITISSSRVTPRRG EEEEEECCCCCCCCC	24.79	25262027
1129	Phosphorylation	FLNGSEVSELLRNLS CCCHHHHHHHHHCCC	20.62	-
1163	Phosphorylation	QYPQLNLSQLLKSSW CCCCCCHHHHHHHHH	20.08	24719451
1256	Phosphorylation	ERLSAVKSSDLINKM CEEHHHCHHHHCCHH	23.61	-
1257	Phosphorylation	RLSAVKSSDLINKMD EEHHHCHHHHCCHHH	30.62	27251275
1274	Phosphorylation	RAAIILGYRIQGVIA HHHHHHCCEEEEEEE	10.91	23612710
1349	Phosphorylation	RQKLQIPSVKGFDFA HHHCCCCCCCCHHHH	37.78	19664994
1385	Phosphorylation	PGPLKDHTTPSENGD CCCCCCCCCCCCCCC	51.00	29255136
1386	Phosphorylation	GPLKDHTTPSENGDV CCCCCCCCCCCCCCC	22.77	29255136
1388	Phosphorylation	LKDHTTPSENGDVPS CCCCCCCCCCCCCCC	41.42	20363803
1395	Phosphorylation	SENGDVPSPKSKIPS CCCCCCCCCCCCCCC	44.82	29255136
1402	Phosphorylation	SPKSKIPSKNVRHRG CCCCCCCCCCCCCCC	40.09	24719451
1412	Phosphorylation	VRHRGRVSPSDADST CCCCCCCCHHHCCCC	19.82	27732954
1414	Phosphorylation	HRGRVSPSDADSTVS CCCCCCHHHCCCCCC	37.61	27732954
1418	Phosphorylation	VSPSDADSTVSEESS CCHHHCCCCCCCCCC	32.22	27732954
1419	Phosphorylation	SPSDADSTVSEESSE CHHHCCCCCCCCCCC	28.71	27732954
1421	Phosphorylation	SDADSTVSEESSERD HHCCCCCCCCCCCCC	35.42	27732954
1424	Phosphorylation	DSTVSEESSERDAGD CCCCCCCCCCCCCCC	33.19	25307156
1425	Phosphorylation	STVSEESSERDAGDK CCCCCCCCCCCCCCC	39.67	27732954
1433	Phosphorylation	ERDAGDKTPGAVNDG CCCCCCCCCCCCCCC	31.52	24719451
1454	Phosphorylation	QSGPPLPSSGNEQHS CCCCCCCCCCCCCCC	59.57	27732954
1455	Phosphorylation	SGPPLPSSGNEQHSS CCCCCCCCCCCCCCC	43.63	27732954
1461	Phosphorylation	SSGNEQHSSASIFEH CCCCCCCCCCHHHHC	27.56	27732954
1462	Phosphorylation	SGNEQHSSASIFEHV CCCCCCCCCHHHHCH	24.74	27732954
1464	Phosphorylation	NEQHSSASIFEHVDR CCCCCCCHHHHCHHH	29.74	27732954
1503	Phosphorylation	APPVQRPSPADRVAE CCCCCCCCHHHHHHH	34.60	25159151
1545	Phosphorylation	RAKRRGHYEFPVVDD HHHHCCCCCCCCCCC	23.30	25884760
1554	Phosphorylation	FPVVDDLSSGDTKER CCCCCCCCCCCHHHH	38.99	27732954
1555	Phosphorylation	PVVDDLSSGDTKERH CCCCCCCCCCHHHHH	48.24	27732954
1558	Phosphorylation	DDLSSGDTKERHRVY CCCCCCCHHHHHHHH	38.03	27732954
1593	Phosphorylation	FIEPRKSSRIKRSPK EECCCCCCCCCCCCC	40.85	-
1598	Phosphorylation	KSSRIKRSPKPRRKH CCCCCCCCCCCCCCC	32.07	23312004
1621	Phosphorylation	AEKDRLITTDSDGTY HHHCCCEEECCCCCC	29.19	23663014
1622	Phosphorylation	EKDRLITTDSDGTYR HHCCCEEECCCCCCC	26.89	23663014
1624	Phosphorylation	DRLITTDSDGTYRRP CCCEEECCCCCCCCC	35.53	23663014
1627	Phosphorylation	ITTDSDGTYRRPPGV EEECCCCCCCCCCCC	20.88	23663014
1628	Phosphorylation	TTDSDGTYRRPPGVH EECCCCCCCCCCCCC	15.34	23663014
1637	Phosphorylation	RPPGVHNSAYIGCPS CCCCCCCCCEECCCC	13.94	27732954
1639	Phosphorylation	PGVHNSAYIGCPSDP CCCCCCCEECCCCCC	9.54	25884760
1644	Phosphorylation	SAYIGCPSDPDLPAD CCEECCCCCCCCCCC	66.89	27732954
1732	Phosphorylation	SQEERRATQWGSFYS CHHHHHHHCCCCCCC	24.04	21945579
1736	Phosphorylation	RRATQWGSFYSPAQT HHHHCCCCCCCHHHC	20.32	21945579
1738	Phosphorylation	ATQWGSFYSPAQTAN HHCCCCCCCHHHCCC	18.55	21945579
1739	Phosphorylation	TQWGSFYSPAQTANN HCCCCCCCHHHCCCC	16.26	21945579
1754	Phosphorylation	PCSRYEDYGMTPPTG CCCCCHHCCCCCCCC	9.25	25884760
1757	Phosphorylation	RYEDYGMTPPTGPLP CCHHCCCCCCCCCCC	23.04	27732954
1800	Phosphorylation	PFAARGIYSEEMPSV CCHHHCCCCCCCCCC	16.92	25884760
1801	Phosphorylation	FAARGIYSEEMPSVA CHHHCCCCCCCCCCC	25.76	25884760
1816	Phosphorylation	RPRPVGGTTGSQIQH CCCCCCCCCHHHHHH	23.27	29449344
1817	Phosphorylation	PRPVGGTTGSQIQHL CCCCCCCCHHHHHHH	37.80	29449344
1819	Phosphorylation	PVGGTTGSQIQHLTQ CCCCCCHHHHHHHHH	23.24	29449344
1855	Phosphorylation	YGGPGWPSYGEDEAG CCCCCCCCCCCCHHH	38.98	25884760
1867	Phosphorylation	EAGRREATHMLGHQE HHHHHHHHHHHCCCC	11.76	29978859
1875	Phosphorylation	HMLGHQEYSSSPLFQ HHHCCCCCCCCCCEE	13.79	29978859
1876	Phosphorylation	MLGHQEYSSSPLFQV HHCCCCCCCCCCEEC	24.48	27732954
1877	Phosphorylation	LGHQEYSSSPLFQVP HCCCCCCCCCCEECC	34.76	29978859
1878	Phosphorylation	GHQEYSSSPLFQVPR CCCCCCCCCCEECCC	21.49	29978859
1886	Phosphorylation	PLFQVPRTSGREPSA CCEECCCCCCCCCCC	29.48	29449344
1887	Phosphorylation	LFQVPRTSGREPSAP CEECCCCCCCCCCCC	36.81	29449344
1892	Phosphorylation	RTSGREPSAPSGNLP CCCCCCCCCCCCCCC	48.32	29449344
1895	Phosphorylation	GREPSAPSGNLPHRG CCCCCCCCCCCCCCC	39.78	19690332
1897	Phosphorylation	EPSAPSGNLPHRGLQ CCCCCCCCCCCCCCC	55.53	32142685
1910	Phosphorylation	LQGPGLGYPTSSTED CCCCCCCCCCCCCCC	14.37	27732954
1912	Phosphorylation	GPGLGYPTSSTEDLQ CCCCCCCCCCCCCCC	27.16	22617229
1913	Phosphorylation	PGLGYPTSSTEDLQP CCCCCCCCCCCCCCC	30.66	28555341
1914	Phosphorylation	GLGYPTSSTEDLQPG CCCCCCCCCCCCCCC	37.99	22496350
1915	Phosphorylation	LGYPTSSTEDLQPGH CCCCCCCCCCCCCCC	33.03	27732954
1923	Phosphorylation	EDLQPGHSSASLIKA CCCCCCCCHHHHHHH	33.25	27732954
1924	Phosphorylation	DLQPGHSSASLIKAI CCCCCCCHHHHHHHH	19.05	27732954
1925	Ubiquitination	LQPGHSSASLIKAIR CCCCCCHHHHHHHHH	16.03	29967540
1926	Phosphorylation	QPGHSSASLIKAIRE CCCCCHHHHHHHHHH	32.35	27732954
1939	Phosphorylation	REELLRLSQKQSTVQ HHHHHHHHHHHHHHH	28.97	29978859
1941	Ubiquitination	ELLRLSQKQSTVQNF HHHHHHHHHHHHHHC	42.72	29967540
1944	Phosphorylation	RLSQKQSTVQNFHS- HHHHHHHHHHHCCC-	24.50	27470641

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K1549_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K1549_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K1549_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYST_HUMAN	DST	physical	12421765
MYO5B_HUMAN	MYO5B	physical	12421765
CAPS1_HUMAN	CADPS	physical	12421765
ITSN2_HUMAN	ITSN2	physical	12421765
MBD5_HUMAN	MBD5	physical	12421765

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K1549_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395, AND MASSSPECTROMETRY.	17081983 [Abstract]