| UniProt ID | BT2A2_HUMAN | |
|---|---|---|
| UniProt AC | Q8WVV5 | |
| Protein Name | Butyrophilin subfamily 2 member A2 | |
| Gene Name | BTN2A2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 523 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein . |
|
| Protein Description | Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.. | |
| Protein Sequence | MEPAAALHFSLPASLLLLLLLLLLSLCALVSAQFTVVGPANPILAMVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRITFVSKDINRGSVALVIHNVTAQENGIYRCYFQEGRSYDEAILRLVVAGLGSKPLIEIKAQEDGSIWLECISGGWYPEPLTVWRDPYGEVVPALKEVSIADADGLFMVTTAVIIRDKYVRNVSCSVNNTLLGQEKETVIFIPESFMPSASPWMVALAVILTASPWMVSMTVILAVFIIFMAVSICCIKKLQREKKILSGEKKVEQEEKEIAQQLQEELRWRRTFLHAADVVLDPDTAHPELFLSEDRRSVRRGPYRQRVPDNPERFDSQPCVLGWESFASGKHYWEVEVENVMVWTVGVCRHSVERKGEVLLIPQNGFWTLEMFGNQYRALSSPERILPLKESLCRVGVFLDYEAGDVSFYNMRDRSHIYTCPRSAFTVPVRPFFRLGSDDSPIFICPALTGASGVMVPEEGLKLHRVGTHQSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | N-linked_Glycosylation | ILAMVGENTTLRCHL EEEEECCCCEEEEEC | 32.22 | UniProtKB CARBOHYD | |
| 61 | Ubiquitination | RCHLSPEKNAEDMEV EEECCCCCCHHHCCH | 65.91 | - | |
| 83 | Ubiquitination | SPAVFVYKGGRERTE CCEEEEEECCCCCCH | 49.97 | - | |
| 104 | Phosphorylation | RGRITFVSKDINRGS HCCEEEEECCCCCCC | 22.03 | 28674151 | |
| 105 | Ubiquitination | GRITFVSKDINRGSV CCEEEEECCCCCCCE | 58.27 | 21906983 | |
| 105 (in isoform 2) | Ubiquitination | - | 58.27 | 21906983 | |
| 105 (in isoform 1) | Ubiquitination | - | 58.27 | 21906983 | |
| 118 | N-linked_Glycosylation | SVALVIHNVTAQENG CEEEEEEEEEHHHCC | 23.01 | UniProtKB CARBOHYD | |
| 151 | Phosphorylation | LVVAGLGSKPLIEIK HHHCCCCCCCEEEEE | 35.82 | 24719451 | |
| 152 (in isoform 2) | Ubiquitination | - | 41.88 | 21906983 | |
| 152 (in isoform 1) | Ubiquitination | - | 41.88 | 21906983 | |
| 152 | Ubiquitination | VVAGLGSKPLIEIKA HHCCCCCCCEEEEEE | 41.88 | 21906983 | |
| 166 (in isoform 3) | Phosphorylation | - | 6.44 | 25332170 | |
| 175 (in isoform 3) | Phosphorylation | - | 10.86 | 25332170 | |
| 186 | Phosphorylation | LTVWRDPYGEVVPAL CEEEECCCCCCCCCC | 30.15 | - | |
| 220 | N-linked_Glycosylation | IRDKYVRNVSCSVNN ECCCCCCCEEEEECC | 21.73 | UniProtKB CARBOHYD | |
| 226 | N-linked_Glycosylation | RNVSCSVNNTLLGQE CCEEEEECCCCCCCC | 21.34 | UniProtKB CARBOHYD | |
| 228 (in isoform 3) | Phosphorylation | - | 20.39 | 24114839 | |
| 234 (in isoform 3) | Phosphorylation | - | 51.28 | 24114839 | |
| 294 | Ubiquitination | KKLQREKKILSGEKK HHHHHHHHHHCCCCH | 44.09 | - | |
| 294 | Acetylation | KKLQREKKILSGEKK HHHHHHHHHHCCCCH | 44.09 | 18603609 | |
| 300 | Acetylation | KKILSGEKKVEQEEK HHHHCCCCHHHHHHH | 66.69 | 18603621 | |
| 307 | Ubiquitination | KKVEQEEKEIAQQLQ CHHHHHHHHHHHHHH | 54.38 | - | |
| 406 | Ubiquitination | CRHSVERKGEVLLIP ECCCCCCCCCEEEEC | 46.01 | 21906983 | |
| 406 (in isoform 1) | Ubiquitination | - | 46.01 | 21906983 | |
| 431 | Phosphorylation | GNQYRALSSPERILP CCEEEECCCHHHHHH | 42.75 | 26699800 | |
| 432 | Phosphorylation | NQYRALSSPERILPL CEEEECCCHHHHHHC | 31.46 | 30576142 | |
| 440 | Ubiquitination | PERILPLKESLCRVG HHHHHHCCHHHEEEE | 43.23 | - | |
| 466 | Phosphorylation | FYNMRDRSHIYTCPR EEECCCCCCEEECCC | 20.65 | 25072903 | |
| 469 | Phosphorylation | MRDRSHIYTCPRSAF CCCCCCEEECCCCCC | 9.25 | 25072903 | |
| 470 | Phosphorylation | RDRSHIYTCPRSAFT CCCCCEEECCCCCCC | 18.54 | 25072903 | |
| 474 | Phosphorylation | HIYTCPRSAFTVPVR CEEECCCCCCCCCCC | 16.93 | 25072903 | |
| 477 | Phosphorylation | TCPRSAFTVPVRPFF ECCCCCCCCCCCCCE | 24.50 | 25072903 | |
| 513 | Ubiquitination | MVPEEGLKLHRVGTH CCCCCCCEEEECCCC | 53.77 | - | |
| 519 | Phosphorylation | LKLHRVGTHQSL--- CEEEECCCCCCC--- | 17.55 | 30576142 | |
| 522 | Phosphorylation | HRVGTHQSL------ EECCCCCCC------ | 28.57 | 28355574 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BT2A2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BT2A2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BT2A2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FATE1_HUMAN | FATE1 | physical | 25416956 | |
| CREB3_HUMAN | CREB3 | physical | 21516116 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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