dbPTM

I17RA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	I17RA_HUMAN
UniProt AC	Q96F46
Protein Name	Interleukin-17 receptor A
Gene Name	IL17RA
Organism	Homo sapiens (Human).
Sequence Length	866
Subcellular Localization	Isoform 1: Cell membrane Single-pass type I membrane protein . Isoform 2: Secreted .
Protein Description	Receptor for IL17A. [PubMed: 17911633]
Protein Sequence	MGAARSPPSAVPGPLLGLLLLLLGVLAPGGASLRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLWVYWFITGISILLVGSVILLIVCMTWRLAGPGSEKYSDDTKYTDGLPAADLIPPPLKPRKVWIIYSADHPLYVDVVLKFAQFLLTACGTEVALDLLEEQAISEAGVMTWVGRQKQEMVESNSKIIVLCSRGTRAKWQALLGRGAPVRLRCDHGKPVGDLFTAAMNMILPDFKRPACFGTYVVCYFSEVSCDGDVPDLFGAAPRYPLMDRFEEVYFRIQDLEMFQPGRMHRVGELSGDNYLRSPGGRQLRAALDRFRDWQVRCPDWFECENLYSADDQDAPSLDEEVFEEPLLPPGTGIVKRAPLVREPGSQACLAIDPLVGEEGGAAVAKLEPHLQPRGQPAPQPLHTLVLAAEEGALVAAVEPGPLADGAAVRLALAGEGEACPLLGSPGAGRNSVLFLPVDPEDSPLGSSTPMASPDLLPEDVREHLEGLMLSLFEQSLSCQAQGGCSRPAMVLTDPHTPYEEEQRQSVQSDQGYISRSSPQPPEGLTEMEEEEEEEQDPGKPALPLSPEDLESLRSLQRQLLFRQLQKNSGWDTMGSESEGPSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	N-linked_Glycosylation	VCSQPGLNCTVKNST EECCCCCCCEECCCC	25.90	19838198
54	N-linked_Glycosylation	GLNCTVKNSTCLDDS CCCCEECCCCCCCCC	37.91	19838198
67	N-linked_Glycosylation	DSWIHPRNLTPSSPK CCCCCCCCCCCCCCC	53.36	19838198
134	Ubiquitination	VRFEFLSKLRHHHRR HHHHHHHHHCHHHHH	52.25	-
206	N-linked_Glycosylation	SGSLWDPNITVETLE CCCCCCCCEEEEEEE	39.84	UniProtKB CARBOHYD
225	N-linked_Glycosylation	RVSFTLWNESTHYQI EEEEEEECCCCCEEE	36.13	19838198
242	N-linked_Glycosylation	TSFPHMENHSCFEHM ECCCCCCCCCCHHHH	25.46	UniProtKB CARBOHYD
264	Phosphorylation	PEEFHQRSNVTLTLR HHHHHHHCCEEEEEC	29.14	-
265	N-linked_Glycosylation	EEFHQRSNVTLTLRN HHHHHHCCEEEEECC	32.74	17660510
354	Ubiquitination	LAGPGSEKYSDDTKY HHCCCCCCCCCCCCC	52.32	33845483
360	Ubiquitination	EKYSDDTKYTDGLPA CCCCCCCCCCCCCCH	53.82	33845483
554	Phosphorylation	MHRVGELSGDNYLRS CEECEECCCCCCCCC	39.54	-
561	Phosphorylation	SGDNYLRSPGGRQLR CCCCCCCCCCHHHHH	25.87	24300666
629	Phosphorylation	PLVREPGSQACLAID CCCCCCCCCEEEEEC	25.89	23401153
708	Phosphorylation	EACPLLGSPGAGRNS CCCCCCCCCCCCCCC	21.82	29255136
726	Phosphorylation	LPVDPEDSPLGSSTP EECCCCCCCCCCCCC	21.99	28270605
730	Phosphorylation	PEDSPLGSSTPMASP CCCCCCCCCCCCCCC	38.43	28270605
731	Phosphorylation	EDSPLGSSTPMASPD CCCCCCCCCCCCCCC	34.43	28270605
732	Phosphorylation	DSPLGSSTPMASPDL CCCCCCCCCCCCCCC	20.84	28270605
736	Phosphorylation	GSSTPMASPDLLPED CCCCCCCCCCCCCHH	16.82	28270605
776	Phosphorylation	SRPAMVLTDPHTPYE CCCEEEECCCCCCCH	35.75	28796482
780	Phosphorylation	MVLTDPHTPYEEEQR EEECCCCCCCHHHHH	32.71	28796482
782	Phosphorylation	LTDPHTPYEEEQRQS ECCCCCCCHHHHHHH	36.81	28796482
792	Phosphorylation	EQRQSVQSDQGYISR HHHHHHHCCCCCCCC	29.73	27732954
796	Phosphorylation	SVQSDQGYISRSSPQ HHHCCCCCCCCCCCC	7.06	27732954
798	Phosphorylation	QSDQGYISRSSPQPP HCCCCCCCCCCCCCC	20.02	27732954
800	Phosphorylation	DQGYISRSSPQPPEG CCCCCCCCCCCCCCC	39.31	28450419
801	Phosphorylation	QGYISRSSPQPPEGL CCCCCCCCCCCCCCC	26.83	26657352
809	Phosphorylation	PQPPEGLTEMEEEEE CCCCCCCCCHHHHHH	44.11	28450419
829	Phosphorylation	GKPALPLSPEDLESL CCCCCCCCHHHHHHH	25.05	20639409
835	Phosphorylation	LSPEDLESLRSLQRQ CCHHHHHHHHHHHHH	36.06	20639409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
780	T	Phosphorylation	Kinase	GSK3A	P49840	PSP
780	T	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of I17RA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of I17RA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_HUMAN	TRAF6	physical	17346928
TRAF6_HUMAN	TRAF6	physical	17277779
M3K7_HUMAN	MAP3K7	physical	17277779
TALD3_HUMAN	KIAA0586	physical	28514442
KS6A3_HUMAN	RPS6KA3	physical	28514442
KS6A2_HUMAN	RPS6KA2	physical	28514442
KS6A1_HUMAN	RPS6KA1	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
DDX11_HUMAN	DDX11	physical	28514442
SIK2_HUMAN	SIK2	physical	28514442
PLCH1_HUMAN	PLCH1	physical	28514442
PKHA5_HUMAN	PLEKHA5	physical	28514442
ZN318_HUMAN	ZNF318	physical	28514442
RICTR_HUMAN	RICTOR	physical	28514442
FANCJ_HUMAN	BRIP1	physical	28514442
TRPS1_HUMAN	TRPS1	physical	28514442
K1671_HUMAN	KIAA1671	physical	28514442
CE034_HUMAN	C5orf34	physical	28514442
GCR_HUMAN	NR3C1	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
GTSE1_HUMAN	GTSE1	physical	28514442
VIP2_HUMAN	PPIP5K2	physical	28514442
SMG8_HUMAN	SMG8	physical	28514442
NCOR1_HUMAN	NCOR1	physical	28514442
MCM8_HUMAN	MCM8	physical	28514442
MAP7_HUMAN	MAP7	physical	28514442
TBL1X_HUMAN	TBL1X	physical	28514442
HASP_HUMAN	GSG2	physical	28514442
UBP54_HUMAN	USP54	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
ICE2_HUMAN	ICE2	physical	28514442
ANKH1_HUMAN	ANKHD1	physical	28514442
HAUS5_HUMAN	HAUS5	physical	28514442
MA7D2_HUMAN	MAP7D2	physical	28514442
BCAS3_HUMAN	BCAS3	physical	28514442
IF4E2_HUMAN	EIF4E2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
HD_HUMAN	HTT	physical	28514442
GRDN_HUMAN	CCDC88A	physical	28514442
ZN644_HUMAN	ZNF644	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442
BCD1_HUMAN	ZNHIT6	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
CN080_HUMAN	C14orf80	physical	28514442
TBCD_HUMAN	TBCD	physical	28514442
LRIF1_HUMAN	LRIF1	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
TASOR_HUMAN	FAM208A	physical	28514442
TBL1R_HUMAN	TBL1XR1	physical	28514442
SIMC1_HUMAN	SIMC1	physical	28514442
HDAC3_HUMAN	HDAC3	physical	28514442
CO039_HUMAN	C15orf39	physical	28514442
IQGA3_HUMAN	IQGAP3	physical	28514442
DYHC2_HUMAN	DYNC2H1	physical	28514442
YETS2_HUMAN	YEATS2	physical	28514442
ESPL1_HUMAN	ESPL1	physical	28514442
TTF2_HUMAN	TTF2	physical	28514442
KAISO_HUMAN	ZBTB33	physical	28514442
TRAF3_HUMAN	TRAF3	physical	28219902
CIKS_HUMAN	TRAF3IP2	physical	28219902

Drug and Disease Associations

Kegg Disease
H00363	Candidiasis
H01109	Chronic mucocutaneous candidiasis (CMC); Familial candidiasis (CANDF)
OMIM Disease
613953	Candidiasis, familial, 5 (CANDF5)
Kegg Drug
D10061	Brodalumab (USAN)
D10071	Ixekizumab (USAN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of I17RA_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Structural basis of receptor sharing by interleukin 17 cytokines."; Ely L.K., Fischer S., Garcia K.C.; Nat. Immunol. 10:1245-1251(2009). Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 32-317 IN COMPLEX WITH IL17F,GLYCOSYLATION AT ASN-49; ASN-54; ASN-67; ASN-225 AND ASN-265,FUNCTION, AND DISULFIDE BONDS.	19838198 [Abstract]