CBWD1_HUMAN - dbPTM
CBWD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CBWD1_HUMAN
UniProt AC Q9BRT8
Protein Name COBW domain-containing protein 1
Gene Name CBWD1
Organism Homo sapiens (Human).
Sequence Length 395
Subcellular Localization
Protein Description
Protein Sequence MLPAVGSADEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTRFQEDQVCT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MLPAVGSADEEEDP
-CCCCCCCCCCCCCC		26.4228102081
33 (in isoform 2)Ubiquitination-67.6721890473
41 (in isoform 4)Ubiquitination-45.8321890473
41 (in isoform 3)Ubiquitination-45.8321890473
41UbiquitinationEKSGLGAKIPVTIIT
HHCCCCCCCCEEEEE		45.8321906983
41 (in isoform 1)Ubiquitination-45.8321890473
55 (in isoform 4)Ubiquitination-37.4921890473
55 (in isoform 3)Ubiquitination-37.4921890473
55UbiquitinationTGYLGAGKTTLLNYI
ECCCCCCHHHHHHHH		37.4921906983
55 (in isoform 1)Ubiquitination-37.4921890473
69 (in isoform 4)Ubiquitination-49.0921890473
69 (in isoform 3)Ubiquitination-49.0921890473
69UbiquitinationILTEQHSKRVAVILN
HHCCCCCCEEEEEEC		49.0921906983
69 (in isoform 1)Ubiquitination-49.0921890473
90 (in isoform 2)Ubiquitination-5.4921890473
91PhosphorylationLEKSLAVSQGGELYE
HHHHHHHHCCCHHHH		19.94-
97PhosphorylationVSQGGELYEEWLELR
HHCCCHHHHHHHHHH		13.90-
113UbiquitinationGCLCCSVKDSGLRAI
CCEEEECCHHHHHHH		29.86-
126 (in isoform 1)Ubiquitination-49.9121890473
126UbiquitinationAIENLMQKKGKFDYI
HHHHHHHHCCCCCEE		49.9121906983
126 (in isoform 3)Ubiquitination-49.9121890473
140 (in isoform 2)Ubiquitination-4.6121890473
146 (in isoform 2)Ubiquitination-5.1321890473
158PhosphorylationWVDAELGSDIYLDGI
EEEHHHCCCEEECCE		33.2028961369
168 (in isoform 2)Ubiquitination-1.9821890473
171PhosphorylationGIITIVDSKYGLKHL
CEEEEEECCCCHHHC		19.5128961369
176 (in isoform 3)Ubiquitination-32.0021890473
176UbiquitinationVDSKYGLKHLTEEKP
EECCCCHHHCCCCCC		32.0021906983
176 (in isoform 1)Ubiquitination-32.0021890473
178 (in isoform 2)Ubiquitination-6.5321890473
182 (in isoform 3)Ubiquitination-42.0221890473
182UbiquitinationLKHLTEEKPDGLINE
HHHCCCCCCCCHHCH		42.022190698
182 (in isoform 1)Ubiquitination-42.0221890473
204 (in isoform 3)Ubiquitination-36.1021890473
204 (in isoform 1)Ubiquitination-36.1021890473
204UbiquitinationADAILINKTDLVPEE
HHHEEECCCCCCCHH		36.1021906983
214UbiquitinationLVPEEDVKKLRTTIR
CCCHHHHHHHHHHHH		59.4121906983
214 (in isoform 3)Ubiquitination-59.4121890473
214 (in isoform 1)Ubiquitination-59.4121890473
222PhosphorylationKLRTTIRSINGLGQI
HHHHHHHHHCCHHHH		19.2927251275
222 (in isoform 2)Ubiquitination-19.2921890473
232PhosphorylationGLGQILETQRSRVDL
CHHHHHHHHHHCCCH		26.3227251275
235PhosphorylationQILETQRSRVDLSNV
HHHHHHHHCCCHHHH		27.1727251275
255PhosphorylationFDSLSGISLQKKLQH
HHCCCCCCHHHHHHC		28.4224719451
258UbiquitinationLSGISLQKKLQHVPG
CCCCCHHHHHHCCCC		61.82-
258 (in isoform 1)Ubiquitination-61.8221890473
289 (in isoform 2)Ubiquitination-24.4821890473
301UbiquitinationIQNLLWEKNVRNKDN
HHHHHHHHHCCCCCC		49.51-
306UbiquitinationWEKNVRNKDNHCMEV
HHHHCCCCCCCHHHE		49.71-
306 (in isoform 3)Ubiquitination-49.7121890473
312 (in isoform 2)Ubiquitination-39.9421890473
317UbiquitinationCMEVIRLKGLVSIKD
HHHEEEEEEEEECCC		40.11-
323UbiquitinationLKGLVSIKDKSQQVI
EEEEEECCCCCCEEE		52.15-
325 (in isoform 1)Ubiquitination-45.2021890473
325UbiquitinationGLVSIKDKSQQVIVQ
EEEECCCCCCEEEEE		45.20-
329 (in isoform 3)Ubiquitination-3.4321890473
334 (in isoform 2)Ubiquitination-1.4521890473
348 (in isoform 1)Ubiquitination-37.9121890473
348UbiquitinationEETPVSWKDDTERTN
CCCCCCCCCCCHHHC		37.91-
351 (in isoform 3)Ubiquitination-37.1821890473
366UbiquitinationLLGRNLDKDILKQLF
EEECCCCHHHHHHHH		50.24-
370UbiquitinationNLDKDILKQLFIATV
CCCHHHHHHHHHHCC		45.34-
370 (in isoform 1)Ubiquitination-45.3421890473
382UbiquitinationATVTETEKQWTTRFQ
HCCCCCHHHHCCCCC		59.56-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CBWD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CBWD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CBWD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBWD6_HUMANCBWD6physical
26186194
CBWD2_HUMANCBWD2physical
26186194
TBB8_HUMANTUBB8physical
26186194
IQGA3_HUMANIQGAP3physical
26186194
OZF_HUMANZNF146physical
26186194
TCRG1_HUMANTCERG1physical
26186194
SRAC1_HUMANSERAC1physical
26186194
TBA1A_HUMANTUBA1Aphysical
26186194
RL23_HUMANRPL23physical
26186194
DC2L1_HUMANDYNC2LI1physical
26186194
TRM6_HUMANTRMT6physical
26186194
PYC_HUMANPCphysical
26186194
EGLN1_HUMANEGLN1physical
26186194
HS12B_HUMANHSPA12Bphysical
26186194
HS12A_HUMANHSPA12Aphysical
26186194
INT11_HUMANCPSF3Lphysical
26186194
NEK4_HUMANNEK4physical
26186194
MAP11_HUMANMETAP1physical
26186194
COX20_HUMANCOX20physical
26186194
TTF2_HUMANTTF2physical
26186194
APC10_HUMANANAPC10physical
26186194
RPP30_HUMANRPP30physical
26186194
RUSD3_HUMANRPUSD3physical
26186194
MELK_HUMANMELKphysical
26186194
UXS1_HUMANUXS1physical
26186194
ERF_HUMANERFphysical
26186194
RA51C_HUMANRAD51Cphysical
26186194
RPP38_HUMANRPP38physical
26186194
MUM1_HUMANMUM1physical
26186194
RPP29_HUMANPOP4physical
26186194
MTFR1_HUMANMTFR1physical
26186194
TRM1L_HUMANTRMT1Lphysical
26186194
SAMD1_HUMANSAMD1physical
26186194
RTEL1_HUMANRTEL1physical
26186194
AGAP1_HUMANAGAP1physical
26186194
PPOX_HUMANPPOXphysical
26186194
ADRO_HUMANFDXRphysical
26186194
PTPM1_HUMANPTPMT1physical
26186194
DDX47_HUMANDDX47physical
26186194
MAP11_HUMANMETAP1physical
28514442
CBWD6_HUMANCBWD6physical
28514442
CBWD2_HUMANCBWD2physical
28514442
AGAP1_HUMANAGAP1physical
28514442
UXS1_HUMANUXS1physical
28514442
SAMD1_HUMANSAMD1physical
28514442
TCRG1_HUMANTCERG1physical
28514442
RL23_HUMANRPL23physical
28514442
TBB8_HUMANTUBB8physical
28514442
NEK4_HUMANNEK4physical
28514442
MELK_HUMANMELKphysical
28514442
ERF_HUMANERFphysical
28514442
TRM6_HUMANTRMT6physical
28514442
PYC_HUMANPCphysical
28514442
PTPM1_HUMANPTPMT1physical
28514442
ADRO_HUMANFDXRphysical
28514442
TTF2_HUMANTTF2physical
28514442
RTEL1_HUMANRTEL1physical
28514442
TBB3_HUMANTUBB3physical
28514442
EGLN1_HUMANEGLN1physical
28514442
RPP29_HUMANPOP4physical
28514442
MTFR1_HUMANMTFR1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CBWD1_HUMAN

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Related Literatures of Post-Translational Modification

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