CBWD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBWD2_HUMAN
• UniProt AC: Q8IUF1
• Protein Name: COBW domain-containing protein 2
• Gene Name: CBWD2
• Organism: Homo sapiens (Human).
• Sequence Length: 395
• Protein Sequence: MLPAVGSADEEEDPAEEDCPELVPMETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLAEEKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRATIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLLGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLPAVGSADEEEDP -CCCCCCCCCCCCCC	26.42	28348404
41	Ubiquitination	EKSGLGAKIPVTIIT HHCCCCCCCCEEEEE	45.83	21890473
55	Ubiquitination	TGYLGAGKTTLLNYI ECCCCCCHHHHHHHH	37.49	21890473
69	Ubiquitination	ILTEQHSKRVAVILN HHCCCCCCEEEEEEC	49.09	21890473
91	Phosphorylation	LEKSLAVSQGGELYE HHHHHHHHCCCHHHH	19.94	-
97	Phosphorylation	VSQGGELYEEWLELR HHCCCHHHHHHHHHH	13.90	-
113	Ubiquitination	GCLCCSVKDNGLRAI CCEEEEECHHHHHHH	29.23	-
126	Ubiquitination	AIENLMQKKGKFDYI HHHHHHHHCCCCCEE	49.91	21890473
127	Ubiquitination	IENLMQKKGKFDYIL HHHHHHHCCCCCEEE	50.90	-
158	Phosphorylation	WVDAELGSDIYLDGI EEEHHHCCCEEECEE	33.20	28961369
171	Phosphorylation	GIITIVDSKYGLKHL EEEEEEECCCHHHHH	19.51	28961369
176	Ubiquitination	VDSKYGLKHLAEEKP EECCCHHHHHHHHCC	32.01	2190698
182	Ubiquitination	LKHLAEEKPDGLINE HHHHHHHCCCCHHCH	39.66	-
204	Ubiquitination	ADAILINKTDLVPEE HHHEEECCCCCCCHH	36.10	21890473
214	Ubiquitination	LVPEEDVKKLRATIR CCCHHHHHHHHHHHH	59.41	21890473
215	Ubiquitination	VPEEDVKKLRATIRS CCHHHHHHHHHHHHH	42.95	-
219	Phosphorylation	DVKKLRATIRSINGL HHHHHHHHHHHHCCH	15.53	25022875
222	Phosphorylation	KLRATIRSINGLGQI HHHHHHHHHCCHHHH	19.29	27251275
232	Phosphorylation	GLGQILETQRSRVDL CHHHHHHHHHHCCCH	26.32	25022875
235	Phosphorylation	QILETQRSRVDLSNV HHHHHHHHCCCHHHH	27.17	27251275
255	Phosphorylation	FDSLSGISLQKKLQH HHCCCCCCHHHHHHC	28.42	24719451
258	Ubiquitination	LSGISLQKKLQHVPG CCCCCHHHHHHCCCC	61.82	21890473
301	Ubiquitination	IQNLLWEKNVRNKDN HHHHHHHHHCCCCCC	49.51	-
306	Ubiquitination	WEKNVRNKDNHCMEV HHHHCCCCCCCHHHE	49.71	-
317	Ubiquitination	CMEVIRLKGLVSIKD HHHEEEEEEEEECCC	40.11	-
323	Ubiquitination	LKGLVSIKDKSQQVI EEEEEECCCCCCEEE	52.15	-
325	Ubiquitination	GLVSIKDKSQQVIVQ EEEECCCCCCEEEEE	45.20	21890473
348	Ubiquitination	EETPVSWKDDTERTN CCCCCCCCCCCHHHC	37.91	21890473
366	Ubiquitination	LLGRNLDKDILKQLF EEECCCCHHHHHHHH	50.24	-
370	Ubiquitination	NLDKDILKQLFIATV CCCHHHHHHHHHHCC	45.34	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBWD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBWD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBWD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_HUMAN	TUBB1	physical	26186194
HS12A_HUMAN	HSPA12A	physical	26186194
EGLN1_HUMAN	EGLN1	physical	26186194
NEK4_HUMAN	NEK4	physical	26186194
MAP11_HUMAN	METAP1	physical	26186194
MAP11_HUMAN	METAP1	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
CAHD1_HUMAN	CACHD1	physical	28514442
TCRG1_HUMAN	TCERG1	physical	28514442
HS12A_HUMAN	HSPA12A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.