CAHD1_HUMAN - dbPTM
CAHD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAHD1_HUMAN
UniProt AC Q5VU97
Protein Name VWFA and cache domain-containing protein 1
Gene Name CACHD1
Organism Homo sapiens (Human).
Sequence Length 1274
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description May regulate voltage-dependent calcium channels..
Protein Sequence MARQPEEEETAVARARRPPLWLLCLVACWLLGAGAEADFSILDEAQVLASQMRRLAAEELGVVTMQRIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTFVSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKATLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIKGSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAGSFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIMEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRFYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCVNSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVRMSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHHLQAAVTVHTVDAEC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
145N-linked_GlycosylationFDGNFNTNVSRTISC
ECCCCCCCCCCEEEE		30.76UniProtKB CARBOHYD
217PhosphorylationYEHRSRPIYVSTVRP
CCCCCCCEEEEECCC		5.29-
265PhosphorylationIDEHDKISVLTVADT
CCCCCCEEEEEHHHH		19.4721406692
268PhosphorylationHDKISVLTVADTVRT
CCCEEEEEHHHHCEE		16.1121406692
272PhosphorylationSVLTVADTVRTCSLD
EEEEHHHHCEECCHH		11.3621406692
294AcetylationSPATSETKRKMSTFV
CCCCHHHHHHHHHHH		46.077661835
298PhosphorylationSETKRKMSTFVSSVK
HHHHHHHHHHHHHHC		23.02-
299PhosphorylationETKRKMSTFVSSVKS
HHHHHHHHHHHHHCC		25.26-
305AcetylationSTFVSSVKSSDSPTQ
HHHHHHHCCCCCCCC		46.307661845
306PhosphorylationTFVSSVKSSDSPTQH
HHHHHHCCCCCCCCH		36.90-
307PhosphorylationFVSSVKSSDSPTQHA
HHHHHCCCCCCCCHH		36.07-
309PhosphorylationSSVKSSDSPTQHAVG
HHHCCCCCCCCHHHH		31.62-
311PhosphorylationVKSSDSPTQHAVGFQ
HCCCCCCCCHHHHHH		36.62-
379PhosphorylationLNNSVMILTYALMND
HHHHHHHHHHHHHCC		1.29-
408PhosphorylationAEQNSGKYGVPDRMA
HHHCCCCCCCCCHHH		27.21-
430PhosphorylationMMVLNQLSNLETTVG
HHHHHHHHCCHHHHH		29.6024719451
435PhosphorylationQLSNLETTVGRFYTN
HHHCCHHHHHHHHHC		16.1624719451
515PhosphorylationFLIDDKGYTLMHPSL
EEECCCCCEEECCCC		11.4824260401
516PhosphorylationLIDDKGYTLMHPSLT
EECCCCCEEECCCCC		26.6924260401
708PhosphorylationVRNEVMATSHVTDEW
EECHHHHCCCCCHHH		10.98-
712PhosphorylationVMATSHVTDEWMTQM
HHHCCCCCHHHHHHH		23.8324719451
722PhosphorylationWMTQMEMSSLNTYIV
HHHHHHHHHCHHHHH		20.5424719451
723PhosphorylationMTQMEMSSLNTYIVR
HHHHHHHHCHHHHHH		25.07-
813PhosphorylationAVMGIDFTLRYFYKV
EEEECHHHHHHHHHH		13.4324719451
1074PhosphorylationIVGAKSPYVDDMGAI
CCCCCCCCCCCCCCC		24.49-
1079PhosphorylationSPYVDDMGAIGDEVI
CCCCCCCCCCCCEEE		22.49-
1087PhosphorylationAIGDEVITLNMIKSA
CCCCEEEEHHHHHCC		19.77-
1093PhosphorylationITLNMIKSAPVGPVA
EEHHHHHCCCCCCCH		27.2125332170
1104PhosphorylationGPVAGGIMGCIMVLV
CCCHHHHHHHHHHHH		3.9724719451
1115PhosphorylationMVLVLAVYAYRHQIH
HHHHHHHHHHHHHHH		7.7222210691
1117PhosphorylationLVLAVYAYRHQIHRR
HHHHHHHHHHHHHHC		7.3122210691
1125PhosphorylationRHQIHRRSHQHMSPL
HHHHHHCCCCCCCHH		27.7021712546
1127PhosphorylationQIHRRSHQHMSPLAA
HHHHCCCCCCCHHHH		34.91-
1130PhosphorylationRRSHQHMSPLAAQEM
HCCCCCCCHHHHHHH		18.0329214152
1138PhosphorylationPLAAQEMSVRMSNLE
HHHHHHHHHHHHCCC		13.0627422710
1155PhosphorylationRDERDDDSHEDRGII
CCCCCCCCCHHCCHH		35.4530242111
1178PhosphorylationVIERHAHSPERRRRY
HHHHHCCCHHHHHHH		29.2820068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAHD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAHD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAHD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CAHD1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAHD1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1178, AND MASSSPECTROMETRY.

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