SRAC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRAC1_HUMAN
• UniProt AC: Q96JX3
• Protein Name: Protein SERAC1
• Gene Name: SERAC1
• Organism: Homo sapiens (Human).
• Sequence Length: 654
• Subcellular Localization: Membrane ; Single-pass membrane protein . Endoplasmic reticulum . Mitochondrion . Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface.
• Protein Description: Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway..
• Protein Sequence: MSLAAYCVICCRRIGTSTSPPKSGTHWRDIRNIIKFTGSLILGGSLFLTYEVLALKKAVTLDTQVVEREKMKSYIYVHTVSLDKGENHGIAWQARKELHKAVRKVLATSAKILRNPFADPFSTVDIEDHECAVWLLLRKSKSDDKTTRLEAVREMSETHHWHDYQYRIIAQACDPKTLIGLARSEESDLRFFLLPPPLPSLKEDSSTEEELRQLLASLPQTELDECIQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEAIVKHSEISTHCDKIEANGGLQLLQRLYRLHKDCPKVQRNIMRVIGNMALNEHLHSSIVRSGWVSIMAEAMKSPHIMESSHAARILANLDRETVQEKYQDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDSEQAVIEKPMEDEDRYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLRKLRAAGVGDRPVVWISHSMGGLLVKKMLLEASTKPEMSTVINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETLPTYIGSMIKLHVVPVESADLGIGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIREALAKDLEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	CCRRIGTSTSPPKSG HCCCCCCCCCCCCCC	22.98	23403867
23	Phosphorylation	TSTSPPKSGTHWRDI CCCCCCCCCCCHHHH	55.48	24719451
104	Ubiquitination	ELHKAVRKVLATSAK HHHHHHHHHHHHHHH	34.69	29967540
108	Phosphorylation	AVRKVLATSAKILRN HHHHHHHHHHHHHHC	25.67	24702127
109	Phosphorylation	VRKVLATSAKILRNP HHHHHHHHHHHHHCC	23.20	24702127
177	Phosphorylation	AQACDPKTLIGLARS HHHCCHHHHEEEECC	29.06	28857561
200	Phosphorylation	LLPPPLPSLKEDSST ECCCCCCCCCCCCCC	60.81	24719451
205	Phosphorylation	LPSLKEDSSTEEELR CCCCCCCCCCHHHHH	40.01	22798277
221	Phosphorylation	LLASLPQTELDECIQ HHHCCCCCCHHHHHH	36.25	-
333	Phosphorylation	ALNEHLHSSIVRSGW HHHHHHHHHHHHHCH	28.28	22210691
334	Phosphorylation	LNEHLHSSIVRSGWV HHHHHHHHHHHHCHH	17.85	22210691
350	Phosphorylation	IMAEAMKSPHIMESS HHHHHHCCCCHHCCH	14.50	29759185
415	Phosphorylation	KTWRQQDSEQAVIEK HHHHHCCHHHCCEEC	27.54	29507054
432	Phosphorylation	EDEDRYTTCWPKTWL CCCCCCCCCCCHHHC	12.02	-
450	Phosphorylation	CPALRIISVEYDTSL CCEEEEEEEEECCCH	13.41	27174698
453	Phosphorylation	LRIISVEYDTSLSDW EEEEEEEECCCHHHH	23.51	27174698
455	Phosphorylation	IISVEYDTSLSDWRA EEEEEECCCHHHHHH	30.57	27174698
456	Phosphorylation	ISVEYDTSLSDWRAR EEEEECCCHHHHHHH	23.99	27174698
458	Phosphorylation	VEYDTSLSDWRARCP EEECCCHHHHHHHCC	34.59	27174698
470	Phosphorylation	RCPMERKSIAFRSNE HCCCCCCCHHHHHHH	25.93	23828894
475	Phosphorylation	RKSIAFRSNELLRKL CCCHHHHHHHHHHHH	28.36	30257219
548	Phosphorylation	EYSVNIRYLLFPSLE EEEEEEEEEECCCCC	12.17	19835603
553	Phosphorylation	IRYLLFPSLEVKELS EEEEECCCCCHHHHC	29.81	21964256
578	Ubiquitination	DDFLEFAKDKNFQVL HHHHHHHHCCCCEEE	74.65	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRAC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRAC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRAC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614739: 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.