dbPTM

IQGA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IQGA3_HUMAN
UniProt AC	Q86VI3
Protein Name	Ras GTPase-activating-like protein IQGAP3
Gene Name	IQGAP3
Organism	Homo sapiens (Human).
Sequence Length	1631
Subcellular Localization
Protein Description
Protein Sequence	MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEACLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGLPSTFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIGGILANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSALLENLREPLAAVYQEMLAQAKMEKAANARNHDDRESQDIYDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEALLKALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLVELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRRVAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQGELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNPATGLAEVEGENAQRYFDALLKLRQERGMGEDFLSWNDLQATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSALLLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAVLWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGKAAQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRPADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTSHLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQARLRGFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYLEWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLYKNWINQTEAQTGQRSHLPYDVTPEQALSHPEVQRRLDIALRNLLAMTDKFLLAITSSVDQIPYGMRYVAKVLKATLAEKFPDATDSEVYKVVGNLLYYRFLNPAVVAPDAFDIVAMAAGGALAAPQRHALGAVAQLLQHAAAGKAFSGQSQHLRVLNDYLEETHLKFRKFIHRACQVPEPEERFAVDEYSDMVAVAKPMVYITVGELVNTHRLLLEHQDCIAPDHQDPLHELLEDLGELPTIPDLIGESIAADGHTDLSKLEVSLTLTNKFEGLEADADDSNTRSLLLSTKQLLADIIQFHPGDTLKEILSLSASREQEAAHKQLMSRRQACTAQTPEPLRRHRSLTAHSLLPLAEKQRRVLRNLRRLEALGLVSARNGYQGLVDELAKDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	AGPGWAAYERLTAEE CCCCCHHHHHHCHHH	8.20	29978859
70	Ubiquitination	RNGVLLAKLGHCFAP HHCCHHHHCCCCCCC	55.78	29967540
83	Ubiquitination	APSVVPLKKIYDVEQ CCCCCCCCCCEEHHH	30.93	29967540
140	Phosphorylation	KNMPRVVYCIHALSL CCCCHHHHHHHHHHH	5.26	20068231
146	Phosphorylation	VYCIHALSLFLFRLG HHHHHHHHHHHHHHC	20.19	20068231
162	Phosphorylation	APQIHDLYGKVKFTA CHHHHHHHCCCCCCH	22.43	28152594
164	Ubiquitination	QIHDLYGKVKFTAEE HHHHHHCCCCCCHHH	28.79	-
166	Ubiquitination	HDLYGKVKFTAEELS HHHHCCCCCCHHHHH	40.25	29967540
168	Phosphorylation	LYGKVKFTAEELSNM HHCCCCCCHHHHHHH	27.69	-
201	O-linked_Glycosylation	GILANELSVDEAAVH CCCCCCCCCCHHHHH	22.73	30379171
201	Phosphorylation	GILANELSVDEAAVH CCCCCCCCCCHHHHH	22.73	-
252	Ubiquitination	AAVYQEMLAQAKMEK HHHHHHHHHHHHHHH	2.92	22505724
308	Phosphorylation	DDALERQSPEALLKA HHHHHHCCHHHHHHH	30.81	22210691
314	Ubiquitination	QSPEALLKALQDPAL CCHHHHHHHHHCHHH	48.15	-
323	Ubiquitination	LQDPALALRGVRRDF HHCHHHHHHHHHHHH	5.21	21890473
324	Methylation	QDPALALRGVRRDFA HCHHHHHHHHHHHHH	35.63	115480435
345	Ubiquitination	LNSDREQKAQELGLV HCCCHHHHHHHHCHH	47.48	29967540
357	Ubiquitination	GLVELLEKEEVQAGV CHHHHHHHHHHHHHH	60.18	29967540
377	Ubiquitination	KGDQEQAMLHAVQRI CCHHHHHHHHHHHHH	2.55	21890473
386	Ubiquitination	HAVQRINKAIRRRVA HHHHHHHHHHHHHHH	42.70	22505724
391	Ubiquitination	INKAIRRRVAADTVK HHHHHHHHHHHHHHH	16.75	22505724
398	"N6,N6-dimethyllysine"	RVAADTVKELMCPEA HHHHHHHHHHCCCHH	47.42	-
398	Methylation	RVAADTVKELMCPEA HHHHHHHHHHCCCHH	47.42	-
490	Ubiquitination	RYFDALLKLRQERGM HHHHHHHHHHHHCCC	42.34	33845483
525	Ubiquitination	TQEETDRVLAVSLIN CHHHHHHHHHHHHHH	4.47	27667366
529	Phosphorylation	TDRVLAVSLINEALD HHHHHHHHHHHHHHH	20.23	24732914
537	Ubiquitination	LINEALDKGSPEKTL HHHHHHHCCCHHHHH	63.24	29967540
539	Phosphorylation	NEALDKGSPEKTLSA HHHHHCCCHHHHHHH	35.31	29255136
542	Ubiquitination	LDKGSPEKTLSALLL HHCCCHHHHHHHHHH	59.14	-
543	Phosphorylation	DKGSPEKTLSALLLP HCCCHHHHHHHHHHH	25.04	28348404
545	Phosphorylation	GSPEKTLSALLLPAA CCHHHHHHHHHHHCC	23.31	28348404
565	Phosphorylation	SLPVAPRYHLLLVAA CCCCCCHHHHHHHHH	8.85	20068231
571	Ubiquitination	RYHLLLVAAKRQKAQ HHHHHHHHHHHHHCC	13.77	21890473
573	Ubiquitination	HLLLVAAKRQKAQVT HHHHHHHHHHHCCCC	45.70	-
576	Ubiquitination	LVAAKRQKAQVTGDP HHHHHHHHCCCCCCC	44.83	29967540
579	Ubiquitination	AKRQKAQVTGDPGAV HHHHHCCCCCCCCCC	8.47	27667366
625	Ubiquitination	QAIKEGKAAQTERVL HHHHHCCCHHHHHHH	18.69	21890473
628	Phosphorylation	KEGKAAQTERVLRNP HHCCCHHHHHHHCCH	22.49	-
656	Ubiquitination	GYQRALESAMAKKQR HHHHHHHHHHHHCCC	24.97	23000965
660	Ubiquitination	ALESAMAKKQRPADT HHHHHHHHCCCCCCC	36.03	-
662	Ubiquitination	ESAMAKKQRPADTAF HHHHHHCCCCCCCEE	56.75	21890473
685	Ubiquitination	GTAYYFHLQTFQGIW CEEEEEEEEEEECHH	3.53	21890473
710	Ubiquitination	SHLTREEIQSAVTKV CCCCHHHHHHHHHHH	3.16	23000965
712	Phosphorylation	LTREEIQSAVTKVTA CCHHHHHHHHHHHHH	30.30	23879269
716	Ubiquitination	EIQSAVTKVTAAYDR HHHHHHHHHHHHHCH	30.87	21890473
721	Phosphorylation	VTKVTAAYDRQQLWK HHHHHHHHCHHHHHH	14.81	23879269
749	Ubiquitination	RGFLVRQKFAEHSHF CHHHHHHHHHHCHHH	35.66	21890473
752	Ubiquitination	LVRQKFAEHSHFLRT HHHHHHHHCHHHHHH	49.40	23000965
803	Ubiquitination	KIQAWARMWAARRQY HHHHHHHHHHHHHHH	1.89	21890473
806	Ubiquitination	AWARMWAARRQYLRR HHHHHHHHHHHHHHH	7.53	23000965
819	Ubiquitination	RRLHYFQKNVNSIVK HHHHHHHHHHHHHHH	53.62	21890473
823	Ubiquitination	YFQKNVNSIVKIQAF HHHHHHHHHHHHHHH	25.19	21890473
824	Ubiquitination	FQKNVNSIVKIQAFF HHHHHHHHHHHHHHH	2.85	21890473
876	Ubiquitination	LAEAELLKLQEEVVR HHHHHHHHHHHHHHH	61.83	29967540
887	Ubiquitination	EVVRKIRSNQQLEQD HHHHHHHCCHHHHHH	42.33	27667366
906	Ubiquitination	DIKIGLLVKNRITLQ HHHHHHHHCCCCCHH	6.58	23000965
907	Ubiquitination	IKIGLLVKNRITLQE HHHHHHHCCCCCHHH	40.24	-
931	Phosphorylation	KRNKEQLSDMMVLDK HCCHHHHHHHHHHCH	24.13	23612710
933	Ubiquitination	NKEQLSDMMVLDKQK CHHHHHHHHHHCHHH	1.47	21890473
938	Acetylation	SDMMVLDKQKGLKSL HHHHHHCHHHCHHHC	50.15	20167786
943	Ubiquitination	LDKQKGLKSLSKEKR HCHHHCHHHCCHHHH	59.00	29967540
944	O-linked_Glycosylation	DKQKGLKSLSKEKRQ CHHHCHHHCCHHHHH	42.81	30379171
947	Acetylation	KGLKSLSKEKRQKLE HCHHHCCHHHHHHHH	72.97	19821017
949	Acetylation	LKSLSKEKRQKLEAY HHHCCHHHHHHHHHH	64.96	19821025
960	Ubiquitination	LEAYQHLFYLLQTQP HHHHHHHHHHHHHCH	3.66	23000965
981	Ubiquitination	IFQMPQNKTTKFMEA HHCCCCCCCCHHHHH	52.93	32015554
1011	Acetylation	YLLLQLFKTALQEEI HHHHHHHHHHHHHHH	41.29	23954790
1011	Succinylation	YLLLQLFKTALQEEI HHHHHHHHHHHHHHH	41.29	23954790
1011	Ubiquitination	YLLLQLFKTALQEEI HHHHHHHHHHHHHHH	41.29	29901268
1012	Phosphorylation	LLLQLFKTALQEEIK HHHHHHHHHHHHHHH	25.85	23312004
1018	Ubiquitination	KTALQEEIKSKVEQP HHHHHHHHHHHCCCC	6.33	23000965
1019	Ubiquitination	TALQEEIKSKVEQPQ HHHHHHHHHHCCCCC	47.72	-
1021	Ubiquitination	LQEEIKSKVEQPQDV HHHHHHHHCCCCCCH	44.80	27667366
1024	Ubiquitination	EIKSKVEQPQDVVTG HHHHHCCCCCCHHCC	43.89	21890473
1025	Ubiquitination	IKSKVEQPQDVVTGN HHHHCCCCCCHHCCC	20.87	27667366
1026	Ubiquitination	KSKVEQPQDVVTGNP HHHCCCCCCHHCCCC	56.69	27667366
1050	Phosphorylation	YRNGRGQSALQEILG HHCCCCHHHHHHHHH	33.50	30266825
1067	Ubiquitination	IQDVLEDKVLSVHTD HHHHHHCCCEEEECC	35.38	22817900
1071	Ubiquitination	LEDKVLSVHTDPVHL HHCCCEEEECCHHHH	5.01	21890473
1072	Ubiquitination	EDKVLSVHTDPVHLY HCCCEEEECCHHHHH	22.60	21890473
1080	Acetylation	TDPVHLYKNWINQTE CCHHHHHHHHHCCCC	52.76	12654913
1080	Ubiquitination	TDPVHLYKNWINQTE CCHHHHHHHHHCCCC	52.76	29967540
1086	Phosphorylation	YKNWINQTEAQTGQR HHHHHCCCCCCCCCC	28.88	24043423
1090	Phosphorylation	INQTEAQTGQRSHLP HCCCCCCCCCCCCCC	42.18	24043423
1098	Phosphorylation	GQRSHLPYDVTPEQA CCCCCCCCCCCHHHH	29.43	22817900
1101	Phosphorylation	SHLPYDVTPEQALSH CCCCCCCCHHHHHCC	20.43	-
1111	Ubiquitination	QALSHPEVQRRLDIA HHHCCHHHHHHHHHH	6.72	21890473
1114	Ubiquitination	SHPEVQRRLDIALRN CCHHHHHHHHHHHHH	21.44	23000965
1134	Phosphorylation	DKFLLAITSSVDQIP HHHHHHHHCCCCCCC	14.89	-
1135	Phosphorylation	KFLLAITSSVDQIPY HHHHHHHCCCCCCCC	23.42	17081983
1136	Phosphorylation	FLLAITSSVDQIPYG HHHHHHCCCCCCCCC	22.51	17081983
1152	Ubiquitination	RYVAKVLKATLAEKF HHHHHHHHHHHHHHC	42.17	23000965
1156	Ubiquitination	KVLKATLAEKFPDAT HHHHHHHHHHCCCCC	17.36	23000965
1157	Ubiquitination	VLKATLAEKFPDATD HHHHHHHHHCCCCCC	59.34	23000965
1158	Ubiquitination	LKATLAEKFPDATDS HHHHHHHHCCCCCCC	57.50	23000965
1162	Ubiquitination	LAEKFPDATDSEVYK HHHHCCCCCCCHHHH	17.34	21890473
1163	Ubiquitination	AEKFPDATDSEVYKV HHHCCCCCCCHHHHH	47.65	21890473
1169	Ubiquitination	ATDSEVYKVVGNLLY CCCCHHHHHHHHHHH	35.30	-
1245	Ubiquitination	YLEETHLKFRKFIHR HHHHHHHHHHHHHHH	35.20	23000965
1248	Ubiquitination	ETHLKFRKFIHRACQ HHHHHHHHHHHHHHC	52.37	23000965
1249	Ubiquitination	THLKFRKFIHRACQV HHHHHHHHHHHHHCC	5.05	21890473
1250	Ubiquitination	HLKFRKFIHRACQVP HHHHHHHHHHHHCCC	2.11	21890473
1252	Ubiquitination	KFRKFIHRACQVPEP HHHHHHHHHHCCCCC	32.04	23000965
1253	Ubiquitination	FRKFIHRACQVPEPE HHHHHHHHHCCCCCH	3.64	23000965
1268	Phosphorylation	ERFAVDEYSDMVAVA HHCCCCCHHHHHHHC	12.90	27259358
1268	Ubiquitination	ERFAVDEYSDMVAVA HHCCCCCHHHHHHHC	12.90	23000965
1269	Phosphorylation	RFAVDEYSDMVAVAK HCCCCCHHHHHHHCC	19.72	-
1289	Phosphorylation	TVGELVNTHRLLLEH EHHHHHHHHHHHHHC	10.82	-
1343	Phosphorylation	DLSKLEVSLTLTNKF CHHHCEEEEEECCCC	13.27	30266825
1345	Phosphorylation	SKLEVSLTLTNKFEG HHCEEEEEECCCCCC	24.83	30266825
1347	Phosphorylation	LEVSLTLTNKFEGLE CEEEEEECCCCCCCC	31.00	30266825
1360	Phosphorylation	LEADADDSNTRSLLL CCCCCCCCCHHHHHH	40.42	20166139
1362	Phosphorylation	ADADDSNTRSLLLST CCCCCCCHHHHHHHH	26.11	20166139
1368	Phosphorylation	NTRSLLLSTKQLLAD CHHHHHHHHHHHHHH	33.26	24719451
1370	Ubiquitination	RSLLLSTKQLLADII HHHHHHHHHHHHHHH	35.26	29967540
1390	Phosphorylation	DTLKEILSLSASREQ CHHHHHHHCCCCHHH	26.41	29449344
1392	Phosphorylation	LKEILSLSASREQEA HHHHHHCCCCHHHHH	22.33	29449344
1394	Phosphorylation	EILSLSASREQEAAH HHHHCCCCHHHHHHH	32.73	29449344
1402	Ubiquitination	REQEAAHKQLMSRRQ HHHHHHHHHHHHHHH	40.16	23000965
1406	Phosphorylation	AAHKQLMSRRQACTA HHHHHHHHHHHHHHC	32.67	29449344
1406	Ubiquitination	AAHKQLMSRRQACTA HHHHHHHHHHHHHHC	32.67	23000965
1407	Ubiquitination	AHKQLMSRRQACTAQ HHHHHHHHHHHHHCC	22.29	23000965
1412	Phosphorylation	MSRRQACTAQTPEPL HHHHHHHHCCCCHHH	25.47	25849741
1415	Phosphorylation	RQACTAQTPEPLRRH HHHHHCCCCHHHHHC	27.44	30266825
1424	Phosphorylation	EPLRRHRSLTAHSLL HHHHHCCCCCHHHHH	24.77	29255136
1426	Phosphorylation	LRRHRSLTAHSLLPL HHHCCCCCHHHHHHH	24.46	30266825
1429	Phosphorylation	HRSLTAHSLLPLAEK CCCCCHHHHHHHHHH	29.18	23927012
1436	Ubiquitination	SLLPLAEKQRRVLRN HHHHHHHHHHHHHHH	43.42	-
1490	Phosphorylation	ELVKLQATLQGLSTK HHHHHHHHHCCCCCC	13.47	20068231
1498	Phosphorylation	LQGLSTKTTFYEEQG HCCCCCCCCEECCCC	23.40	26552605
1499	Phosphorylation	QGLSTKTTFYEEQGD CCCCCCCCEECCCCC	26.27	26552605
1501	Phosphorylation	LSTKTTFYEEQGDYY CCCCCCEECCCCCHH	19.23	26552605
1507	Phosphorylation	FYEEQGDYYSQYIRA EECCCCCHHHHHHHH	16.31	26552605
1508	Phosphorylation	YEEQGDYYSQYIRAC ECCCCCHHHHHHHHH	8.27	26552605
1509	Phosphorylation	EEQGDYYSQYIRACL CCCCCHHHHHHHHHH	15.41	26552605
1511	Phosphorylation	QGDYYSQYIRACLDH CCCHHHHHHHHHHHH	6.09	26552605
1523	Phosphorylation	LDHLAPDSKSSGKGK HHHHCCCCCCCCCCC	33.12	-
1524	Ubiquitination	DHLAPDSKSSGKGKK HHHCCCCCCCCCCCC	56.89	33845483
1525	Phosphorylation	HLAPDSKSSGKGKKQ HHCCCCCCCCCCCCC	48.55	-
1526	Phosphorylation	LAPDSKSSGKGKKQP HCCCCCCCCCCCCCC	48.54	-
1531	Ubiquitination	KSSGKGKKQPSLHYT CCCCCCCCCCCHHHH	75.90	29967540
1537	Phosphorylation	KKQPSLHYTAAQLLE CCCCCHHHHHHHHHH	11.90	22817900
1538	Phosphorylation	KQPSLHYTAAQLLEK CCCCHHHHHHHHHHC	12.55	-
1545	Ubiquitination	TAAQLLEKGVLVEIE HHHHHHHCCCEEEEE	55.05	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IQGA3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IQGA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IQGA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IST1_HUMAN	IST1	physical	26344197
MYH2_HUMAN	MYH2	physical	26344197
TERA_HUMAN	VCP	physical	28970065

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IQGA3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1424, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539; THR-1415 ANDSER-1424, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1537, AND MASSSPECTROMETRY.	18083107 [Abstract]