UXS1_HUMAN - dbPTM
UXS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UXS1_HUMAN
UniProt AC Q8NBZ7
Protein Name UDP-glucuronic acid decarboxylase 1
Gene Name UXS1
Organism Homo sapiens (Human).
Sequence Length 420
Subcellular Localization Golgi apparatus, Golgi stack membrane
Single-pass type II membrane protein.
Protein Description Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis..
Protein Sequence MVSKALLRLVSAVNRRRMKLLLGIALLAYVASVWGNFVNMRSIQENGELKIESKIEEMVEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARIKKGRTRHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVSKALLR
-------CHHHHHHH		7.4825732826
4Ubiquitination----MVSKALLRLVS
----CHHHHHHHHHH		31.4829901268
42O-linked_GlycosylationGNFVNMRSIQENGEL
HHCCCHHHHHHCCCE		20.18OGP
53PhosphorylationNGELKIESKIEEMVE
CCCEEEHHHHHHHHH		42.2630108239
86AcetylationPVKFLSEKDRKRILI
CCEECCHHHCCEEEE		60.5030593309
89AcetylationFLSEKDRKRILITGG
ECCHHHCCEEEEECC		54.6630593315
94PhosphorylationDRKRILITGGAGFVG
HCCEEEEECCCCHHH		26.5614702039
102PhosphorylationGGAGFVGSHLTDKLM
CCCCHHHHHHHHHHC		15.2619690332
105PhosphorylationGFVGSHLTDKLMMDG
CHHHHHHHHHHCCCC		26.1819690332
175PhosphorylationYMYNPIKTLKTNTIG
CCCCCCHHCCCCCCC		33.9220068231
178PhosphorylationNPIKTLKTNTIGTLN
CCCHHCCCCCCCHHH		40.48-
180PhosphorylationIKTLKTNTIGTLNML
CHHCCCCCCCHHHHH		26.4720068231
183PhosphorylationLKTNTIGTLNMLGLA
CCCCCCCHHHHHHHH		15.8820068231
316N-linked_GlycosylationLVALMNSNVSSPVNL
HHHHHCCCCCCCCCC		32.46UniProtKB CARBOHYD
397PhosphorylationYFRKELEYQANNQYI
HHHHHHHHHHCCCCC		26.0825072903
403PhosphorylationEYQANNQYIPKPKPA
HHHHCCCCCCCCCCC		22.7025072903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UXS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UXS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UXS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPSB3_HUMANSPSB3physical
28514442
TSK_HUMANTSKUphysical
28514442
NOP9_HUMANNOP9physical
28514442
ANK3_HUMANANK3physical
28514442
XPO4_HUMANXPO4physical
28514442
VPS8_HUMANVPS8physical
28514442
FA98A_HUMANFAM98Aphysical
28514442
HEAT3_HUMANHEATR3physical
28514442
VPS18_HUMANVPS18physical
28514442
NU160_HUMANNUP160physical
28514442
NUP98_HUMANNUP98physical
28514442
SAAL1_HUMANSAAL1physical
28514442
NUP85_HUMANNUP85physical
28514442
RMND1_HUMANRMND1physical
28514442
EI2BG_HUMANEIF2B3physical
28514442
MK03_HUMANMAPK3physical
28514442
HS2ST_HUMANHS2ST1physical
28514442
TTYH3_HUMANTTYH3physical
28514442
COX1_HUMANCOX1physical
28514442
DDX1_HUMANDDX1physical
28514442
LMBR1_HUMANLMBR1physical
28514442
NU107_HUMANNUP107physical
28514442
IPO7_HUMANIPO7physical
28514442
EI2BE_HUMANEIF2B5physical
28514442
TBC15_HUMANTBC1D15physical
28514442
GEMI4_HUMANGEMIN4physical
28514442
PP4R2_HUMANPPP4R2physical
28514442
COG3_HUMANCOG3physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UXS1_HUMAN

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Related Literatures of Post-Translational Modification

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