PLCH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCH1_HUMAN
• UniProt AC: Q4KWH8
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
• Gene Name: PLCH1
• Organism: Homo sapiens (Human).
• Sequence Length: 1693
• Subcellular Localization: Cytoplasm . Membrane .
• Protein Description: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes..
• Protein Sequence: MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	41.21	22210691
7	Phosphorylation	-MADLEVYKNLSPEK -CCCHHHHHCCCHHH	5.70	30576142
8 (in isoform 2)	Phosphorylation	-	57.50	22210691
11	Phosphorylation	LEVYKNLSPEKVERC HHHHHCCCHHHHHHH	40.17	30576142
20	Phosphorylation	EKVERCMSVMQSGTQ HHHHHHHHHHHHCCC	20.33	27273156
24	Phosphorylation	RCMSVMQSGTQMIKL HHHHHHHHCCCEEEE	26.22	29978859
26	Phosphorylation	MSVMQSGTQMIKLKR HHHHHHCCCEEEECC	21.88	28258704
35	Phosphorylation	MIKLKRGTKGLVRLF EEEECCCCCCEEEEE	26.44	28258704
59	Phosphorylation	RWRPSRKSEKAKILI CCCCCCHHHHHHHHH	43.13	-
68	Phosphorylation	KAKILIDSIYKVTEG HHHHHHHHHHHHCCC	22.33	-
70	Phosphorylation	KILIDSIYKVTEGRQ HHHHHHHHHHCCCCC	11.89	20049867
125	Phosphorylation	TWITGLKYLMAGISD HHHHHHHHHHHCCCC	13.52	24114839
135	Phosphorylation	AGISDEDSLAKRQRT HCCCCHHHHHHHHHH	28.33	22985185
212	Phosphorylation	CVFYKMMSLRRDLYL HHHHHHHHHHHHHHH	18.41	22210691
218	Phosphorylation	MSLRRDLYLLLLSYS HHHHHHHHHHHHHCC	10.29	26074081
223	Phosphorylation	DLYLLLLSYSDKKDH HHHHHHHHCCCCCCC	23.66	26074081
224	Phosphorylation	LYLLLLSYSDKKDHL HHHHHHHCCCCCCCC	22.36	22210691
225	Phosphorylation	YLLLLSYSDKKDHLT HHHHHHCCCCCCCCC	39.31	22210691
232	Phosphorylation	SDKKDHLTVEELAQF CCCCCCCCHHHHHHH	23.58	26074081
264	Phosphorylation	IIKKFEVSEENKVKN HHHHCCCCCCHHHCE	31.81	25159151
332	Phosphorylation	SQSKVDMYARVLQEG CHHHHHHHHHHHHCC	6.18	-
431	Phosphorylation	GECKQLPSPQSLKGK CCCCCCCCCCCCCCE	44.13	22210691
434	Phosphorylation	KQLPSPQSLKGKILV CCCCCCCCCCCEEEE	35.12	21060948
448	Phosphorylation	VKGKKLPYHLGDDAE ECCCCCCCCCCCCCC	21.80	21406692
460	Phosphorylation	DAEEGEVSDEDSADE CCCCCCCCCCCCHHH	30.86	25849741
464	Phosphorylation	GEVSDEDSADEIEDE CCCCCCCCHHHHHHH	35.26	25849741
478	Phosphorylation	ECKFKLHYSNGTTEH HHEEEEEECCCCCHH	17.80	-
497	Phosphorylation	FIRKKLESLLKESQI HHHHHHHHHHHHHHC	49.81	24719451
514	Phosphorylation	KEDPDSFTVRALLKA CCCCCCHHHHHHHHH	17.03	24719451
533	Phosphorylation	LNAHLKQSPDVKESG HHHHHHCCCCHHHHC	22.83	24719451
536	Ubiquitination	HLKQSPDVKESGKKS HHHCCCCHHHHCCCC	9.34	25015289
538	Ubiquitination	KQSPDVKESGKKSHG HCCCCHHHHCCCCCC	65.65	25015289
539	Ubiquitination	QSPDVKESGKKSHGR CCCCHHHHCCCCCCH	50.63	25015289
542	Ubiquitination	DVKESGKKSHGRSLM CHHHHCCCCCCHHHH	51.73	25015289
554	Ubiquitination	SLMTNFGKHKKTTKS HHHHHCCCCCCCCCC	48.38	25015289
556	Ubiquitination	MTNFGKHKKTTKSRS HHHCCCCCCCCCCCC	56.13	25015289
557	Ubiquitination	TNFGKHKKTTKSRSK HHCCCCCCCCCCCCC	62.23	25015289
560	Ubiquitination	GKHKKTTKSRSKSYS CCCCCCCCCCCCCCC	49.45	25015289
563	Phosphorylation	KKTTKSRSKSYSTDD CCCCCCCCCCCCCCC	32.80	23911959
565	Phosphorylation	TTKSRSKSYSTDDEE CCCCCCCCCCCCCHH	26.09	28985074
566	Phosphorylation	TKSRSKSYSTDDEED CCCCCCCCCCCCHHH	21.23	21406692
566	Ubiquitination	TKSRSKSYSTDDEED CCCCCCCCCCCCHHH	21.23	25015289
567	Phosphorylation	KSRSKSYSTDDEEDT CCCCCCCCCCCHHHH	32.24	30576142
568	Phosphorylation	SRSKSYSTDDEEDTQ CCCCCCCCCCHHHHH	38.96	28985074
568	Ubiquitination	SRSKSYSTDDEEDTQ CCCCCCCCCCHHHHH	38.96	25015289
569	Ubiquitination	RSKSYSTDDEEDTQQ CCCCCCCCCHHHHHH	56.22	25015289
572	Ubiquitination	SYSTDDEEDTQQSTG CCCCCCHHHHHHHCC	73.65	25015289
574	Phosphorylation	STDDEEDTQQSTGKE CCCCHHHHHHHCCCH	31.61	30576142
577	Phosphorylation	DEEDTQQSTGKEGGQ CHHHHHHHCCCHHHH	29.34	30576142
578	Phosphorylation	EEDTQQSTGKEGGQL HHHHHHHCCCHHHHH	48.19	21406692
586	Phosphorylation	GKEGGQLYRLGRRRK CCHHHHHHHHHHHHH	8.90	-
627	Phosphorylation	GTTGNVLSFSETRAH CCCCCEECCCHHHHH	23.57	-
740	Phosphorylation	QLILKVISGQQLPKP EEEEEECCCCCCCCC	33.27	21406692
899	Phosphorylation	FNKNPRHSSSENNSH CCCCCCCCCCCCCCH	36.52	24719451
900	Phosphorylation	NKNPRHSSSENNSHY CCCCCCCCCCCCCHH	35.23	21406692
901	Phosphorylation	KNPRHSSSENNSHYV CCCCCCCCCCCCHHE	47.56	21406692
905	Phosphorylation	HSSSENNSHYVRKRS CCCCCCCCHHEEHHH	27.98	28152594
907	Phosphorylation	SSENNSHYVRKRSIG CCCCCCHHEEHHHHH	11.19	28152594
912	Phosphorylation	SHYVRKRSIGDRILR CHHEEHHHHHHHHHH	33.68	26434776
921	Phosphorylation	GDRILRRTASAPAKG HHHHHHHHCCCCCCC	20.66	28102081
923	Phosphorylation	RILRRTASAPAKGRK HHHHHHCCCCCCCCC	33.89	24719451
932	Phosphorylation	PAKGRKKSKMGFQEM CCCCCCCCCCCHHHH	30.80	29255136
963	Phosphorylation	VLRRTTRSLQARPVS CCHHHCCCCCCCCCC	23.81	21406692
970	Phosphorylation	SLQARPVSMPVDRNL CCCCCCCCCCCCCCH	21.76	27422710
982	Phosphorylation	RNLLGALSLPVSETA CCHHHHHCCCCCHHH	30.05	21406692
986	Phosphorylation	GALSLPVSETAKDIE HHHCCCCCHHHHHCC	27.56	21406692
988	Phosphorylation	LSLPVSETAKDIEGK HCCCCCHHHHHCCCC	31.34	21406692
1012	Phosphorylation	GRRKGKASIKDPHFL CCCCCCCCCCCHHHC	33.39	21406692
1012 (in isoform 4)	Phosphorylation	-	33.39	24260401
1026	Phosphorylation	LNFNKKLSSSSSALL CCCCHHCCCCCHHHC	36.73	21406692
1027	Phosphorylation	NFNKKLSSSSSALLH CCCHHCCCCCHHHCC	44.68	21406692
1028	Phosphorylation	FNKKLSSSSSALLHK CCHHCCCCCHHHCCC	25.57	25849741
1029	Phosphorylation	NKKLSSSSSALLHKD CHHCCCCCHHHCCCC	22.90	21406692
1030	Phosphorylation	KKLSSSSSALLHKDT HHCCCCCHHHCCCCC	25.53	21406692
1046	Phosphorylation	QGDTIVSTAHMSVTG CCCCEEEEEEEEECH	15.08	22210691
1052	Phosphorylation	STAHMSVTGEQLGMS EEEEEEECHHHCCCC	27.91	22210691
1059	Phosphorylation	TGEQLGMSSPRGGRT CHHHCCCCCCCCCCC	35.08	22210691
1060	Phosphorylation	GEQLGMSSPRGGRTT HHHCCCCCCCCCCCC	15.10	28348404
1066	Phosphorylation	SSPRGGRTTSNATSN CCCCCCCCCCCCCCC	37.54	24719451
1067	Phosphorylation	SPRGGRTTSNATSNC CCCCCCCCCCCCCCC	20.72	28348404
1068	Phosphorylation	PRGGRTTSNATSNCQ CCCCCCCCCCCCCCC	24.69	28348404
1071	Phosphorylation	GRTTSNATSNCQENP CCCCCCCCCCCCCCC	25.40	28348404
1072	Phosphorylation	RTTSNATSNCQENPC CCCCCCCCCCCCCCC	32.95	23312004
1083	Phosphorylation	ENPCPSKSLSPKQHL CCCCCCCCCCCCCCC	38.12	24719451
1085	Phosphorylation	PCPSKSLSPKQHLAP CCCCCCCCCCCCCCC	36.82	24719451
1099	Phosphorylation	PDPVVNPTQDLHGVK CCCCCCCCCCCCCCE	29.52	21406692
1129	Phosphorylation	ILSGSVLSHSNLEIK ECCCCCCCCCCCEEE	23.78	27251275
1131	Phosphorylation	SGSVLSHSNLEIKNL CCCCCCCCCCEEEEC	39.47	27251275
1247	Phosphorylation	HGFCKGKSKSSFLCS CCCCCCCCCCCCCCC	46.57	28348404
1249	Phosphorylation	FCKGKSKSSFLCSSP CCCCCCCCCCCCCCH	33.15	28348404
1250	Phosphorylation	CKGKSKSSFLCSSPE CCCCCCCCCCCCCHH	26.44	24719451
1254	Phosphorylation	SKSSFLCSSPELIAL CCCCCCCCCHHEEEE	51.58	28348404
1255	Phosphorylation	KSSFLCSSPELIALS CCCCCCCCHHEEEEC	22.77	24719451
1271	Phosphorylation	SETTKHATNTVYETT CCCCCCCCCCEEEEE	31.01	23663014
1273	Phosphorylation	TTKHATNTVYETTCT CCCCCCCCEEEEEEC	21.80	23663014
1275	Phosphorylation	KHATNTVYETTCTPI CCCCCCEEEEEECCC	12.91	23663014
1277	Phosphorylation	ATNTVYETTCTPISK CCCCEEEEEECCCCC	14.96	23663014
1278	Phosphorylation	TNTVYETTCTPISKT CCCEEEEEECCCCCC	11.48	23663014
1280	Phosphorylation	TVYETTCTPISKTKP CEEEEEECCCCCCCC	22.89	22210691
1283	Phosphorylation	ETTCTPISKTKPDDD EEEECCCCCCCCCCC	35.16	23663014
1285	Phosphorylation	TCTPISKTKPDDDLS EECCCCCCCCCCCCC	40.81	22210691
1297	Phosphorylation	DLSSKAKTAALESNL CCCHHHHHHHHHHCC	23.25	21406692
1302	Phosphorylation	AKTAALESNLPGSPN HHHHHHHHCCCCCCC	44.51	26657352
1307	Phosphorylation	LESNLPGSPNTSRGW HHHCCCCCCCCCCCC	17.03	19664994
1310	Phosphorylation	NLPGSPNTSRGWLPK CCCCCCCCCCCCCCC	24.16	29978859
1311	Phosphorylation	LPGSPNTSRGWLPKS CCCCCCCCCCCCCCC	35.12	20201521
1318	Phosphorylation	SRGWLPKSPTKGEDW CCCCCCCCCCCCCCH	35.54	27422710
1320	Phosphorylation	GWLPKSPTKGEDWET CCCCCCCCCCCCHHH	59.79	29978859
1340	Phosphorylation	PASSPDLTLEDVIAD CCCCCCCCHHHHHCC	35.17	28985074
1349	Phosphorylation	EDVIADPTLCFNSGE HHHHCCCEEEECCCC	36.38	28985074
1381	Phosphorylation	CEYRREGTSQLASPL EEEECCCCCCCCCCE	14.46	21406692
1382	Phosphorylation	EYRREGTSQLASPLK EEECCCCCCCCCCEE	33.77	21406692
1386	Phosphorylation	EGTSQLASPLKLKYN CCCCCCCCCEECCCC	39.08	19664994
1391	Methylation	LASPLKLKYNQGVVE CCCCEECCCCHHHHH	40.34	115975097
1416	Phosphorylation	CKETLRPSVPEIFNN CHHHCCCCHHHHHHC	43.82	24719451
1433	Phosphorylation	DVKTQSISYLAYQGA HHHHCCCCEEHHCCC	21.24	-
1437	Phosphorylation	QSISYLAYQGAGFVH CCCCEEHHCCCCCCC	12.60	-
1488	Phosphorylation	LPALKLPSPCKSKSL CCCCCCCCCCCCCCC	54.06	24719451
1492	Phosphorylation	KLPSPCKSKSLGDLT CCCCCCCCCCCCCCC	33.91	29978859
1493	Ubiquitination	LPSPCKSKSLGDLTS CCCCCCCCCCCCCCH	34.88	29967540
1494	Phosphorylation	PSPCKSKSLGDLTSE CCCCCCCCCCCCCHH	44.68	22617229
1499	Phosphorylation	SKSLGDLTSEDIACN CCCCCCCCHHHHCCC	34.51	29978859
1500	Phosphorylation	KSLGDLTSEDIACNF CCCCCCCHHHHCCCC	40.34	21406692
1509	Phosphorylation	DIACNFESKYQCISK HHCCCCHHHEEEEEE	32.31	-
1511	Phosphorylation	ACNFESKYQCISKSF CCCCHHHEEEEEEHH	20.21	-
1517	Phosphorylation	KYQCISKSFVTTGIR HEEEEEEHHHCCCCC	20.40	24719451
1520	Phosphorylation	CISKSFVTTGIRDKK EEEEHHHCCCCCCCC	19.79	-
1521	Phosphorylation	ISKSFVTTGIRDKKG EEEHHHCCCCCCCCC	25.88	-
1530	O-linked_Glycosylation	IRDKKGVTVKTKSLE CCCCCCCEEEECCCC	25.59	30379171
1533	Phosphorylation	KKGVTVKTKSLEPID CCCCEEEECCCCCHH	22.87	24719451
1535	O-linked_Glycosylation	GVTVKTKSLEPIDAL CCEEEECCCCCHHHH	43.10	30379171
1535	Phosphorylation	GVTVKTKSLEPIDAL CCEEEECCCCCHHHH	43.10	27050516
1543	O-linked_Glycosylation	LEPIDALTEQLRKLV CCCHHHHHHHHHHHH	24.33	30379171
1548	Ubiquitination	ALTEQLRKLVSFDQE HHHHHHHHHHCCCCC	62.93	29967540
1551	Phosphorylation	EQLRKLVSFDQEDNC HHHHHHHCCCCCCCE	33.28	24245541
1562	Phosphorylation	EDNCQVLYSKQDANQ CCCEEEEECHHCCCH	18.24	27642862
1579	Phosphorylation	RALVRKLSSRSQSRV HHHHHHHHHHHHHHH	27.09	24505115
1584	Phosphorylation	KLSSRSQSRVRNIAS HHHHHHHHHHHHHHH	33.71	24505115
1620	Phosphorylation	VVLRNKPSAPTPAVN EEEECCCCCCCCCCC	48.79	21406692
1623	Phosphorylation	RNKPSAPTPAVNRHS ECCCCCCCCCCCCCC	24.48	21406692
1630	Phosphorylation	TPAVNRHSTGSYIAG CCCCCCCCCCCCHHC	31.09	25849741
1631	Phosphorylation	PAVNRHSTGSYIAGY CCCCCCCCCCCHHCE	24.83	28152594
1633	Phosphorylation	VNRHSTGSYIAGYLK CCCCCCCCCHHCEEE	17.29	28152594
1634	Phosphorylation	NRHSTGSYIAGYLKN CCCCCCCCHHCEEEC	8.99	28152594
1638	Phosphorylation	TGSYIAGYLKNTKGG CCCCHHCEEECCCCC	12.89	28152594
1662	Phosphorylation	GACTALHYGHVDQFC CCCHHCCCCCHHHHC	15.13	22817900
1688	Phosphorylation	SDDKPEIYFLLRL-- CCCCCEEEEEEEC--	6.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCH1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLCH1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1307 AND SER-1494, ANDMASS SPECTROMETRY.
PubMed: 19413330