MET17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET17_HUMAN
• UniProt AC: Q9H7H0
• Protein Name: Methyltransferase-like protein 17, mitochondrial
• Gene Name: METTL17
• Organism: Homo sapiens (Human).
• Sequence Length: 456
• Subcellular Localization: Mitochondrion.
• Protein Description: May be a component of the mitochondrial small ribosomal subunit..
• Protein Sequence: MAAALKCLLTLGRWCPGLGVAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLENPDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Phosphorylation	TMENQVQTLTSYLWS CHHHHHHHHHHHHHH	32.90	21406692
91	Phosphorylation	ENQVQTLTSYLWSRH HHHHHHHHHHHHHCC	20.79	21406692
92	Phosphorylation	NQVQTLTSYLWSRHL HHHHHHHHHHHHCCC	22.72	21406692
93	Phosphorylation	QVQTLTSYLWSRHLP HHHHHHHHHHHCCCC	13.62	21406692
96	Phosphorylation	TLTSYLWSRHLPVEP HHHHHHHHCCCCCCH	13.76	21406692
116	Ubiquitination	RARHLEKKFLENPDL HHHHHHHHHHHCCCH	45.89	-
116	Acetylation	RARHLEKKFLENPDL HHHHHHHHHHHCCCH	45.89	25953088
124	Phosphorylation	FLENPDLSQTEEKLR HHHCCCHHHHHHHHH	42.30	-
126	Phosphorylation	ENPDLSQTEEKLRGA HCCCHHHHHHHHHHH	42.61	25159151
129	Ubiquitination	DLSQTEEKLRGAVLH CHHHHHHHHHHHHHH	36.93	-
129 (in isoform 3)	Ubiquitination	-	36.93	-
200	Phosphorylation	GSGTGSVTWAAHSIW CCCCCCCHHHCHHHH	15.87	-
205	Phosphorylation	SVTWAAHSIWGQSLR CCHHHCHHHHCCCHH	18.47	-
254	Phosphorylation	FRQFLPVSPKVQFDV EECCCCCCCCCEEEE	19.64	-
273	Phosphorylation	FSLSELPSKADRTEV CCHHHCCCCCCHHHH	53.77	24719451
315	Acetylation	DARDLVLKGKEKSPL HHHHHHHCCCCCCCC	61.53	25953088
416	Phosphorylation	HMQHAVLTARRHGRD CHHHHHHHHHHHCCC	16.12	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP70_HUMAN	CEP70	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
TRIP6_HUMAN	TRIP6	physical	21516116
CH60_HUMAN	HSPD1	physical	28514442
FABD_HUMAN	MCAT	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.