| UniProt ID | RRFM_HUMAN | |
|---|---|---|
| UniProt AC | Q96E11 | |
| Protein Name | Ribosome-recycling factor, mitochondrial | |
| Gene Name | MRRF | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 262 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).. | |
| Protein Sequence | MALGLKCFRMVHPTFRNYLAASIRPVSEVTLKTVHERQHGHRQYMAYSAVPVRHFATKKAKAKGKGQSQTRVNINAALVEDIINLEEVNEEMKSVIEALKDNFNKTLNIRTSPGSLDKIAVVTADGKLALNQISQISMKSPQLILVNMASFPECTAAAIKAIRESGMNLNPEVEGTLIRVPIPQVTREHREMLVKLAKQNTNKAKDSLRKVRTNSMNKLKKSKDTVSEDTIRLIEKQISQMADDTVAELDRHLAVKTKELLG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | Phosphorylation | GHRQYMAYSAVPVRH CCCCEEEEECCCCHH | 4.80 | 22817900 | |
| 71 (in isoform 8) | Phosphorylation | - | 16.31 | 22210691 | |
| 96 (in isoform 7) | Phosphorylation | - | 3.11 | 29083192 | |
| 100 | Succinylation | KSVIEALKDNFNKTL HHHHHHHHHHHCCCC | 58.64 | 23954790 | |
| 100 | Malonylation | KSVIEALKDNFNKTL HHHHHHHHHHHCCCC | 58.64 | 26320211 | |
| 100 | Acetylation | KSVIEALKDNFNKTL HHHHHHHHHHHCCCC | 58.64 | 26822725 | |
| 105 | Malonylation | ALKDNFNKTLNIRTS HHHHHHCCCCCEECC | 50.69 | 26320211 | |
| 106 (in isoform 7) | Phosphorylation | - | 26.58 | 29083192 | |
| 112 | Phosphorylation | KTLNIRTSPGSLDKI CCCCEECCCCCCCEE | 19.88 | - | |
| 115 | Phosphorylation | NIRTSPGSLDKIAVV CEECCCCCCCEEEEE | 36.46 | - | |
| 130 | Ubiquitination | TADGKLALNQISQIS ECCCEEHHHHHHHHC | 7.60 | 24816145 | |
| 134 | Phosphorylation | KLALNQISQISMKSP EEHHHHHHHHCCCCC | 16.23 | 20068231 | |
| 140 (in isoform 6) | Phosphorylation | - | 14.83 | 29083192 | |
| 150 (in isoform 6) | Phosphorylation | - | 30.48 | 29083192 | |
| 154 | Glutathionylation | NMASFPECTAAAIKA ECCCCHHHHHHHHHH | 2.98 | 22555962 | |
| 160 | Acetylation | ECTAAAIKAIRESGM HHHHHHHHHHHHHCC | 32.79 | 26051181 | |
| 165 | Phosphorylation | AIKAIRESGMNLNPE HHHHHHHHCCCCCHH | 33.23 | - | |
| 165 (in isoform 2) | Phosphorylation | - | 33.23 | - | |
| 167 | Sulfoxidation | KAIRESGMNLNPEVE HHHHHHCCCCCHHHC | 7.79 | 21406390 | |
| 169 | Ubiquitination | IRESGMNLNPEVEGT HHHHCCCCCHHHCCE | 9.32 | 24816145 | |
| 176 | Phosphorylation | LNPEVEGTLIRVPIP CCHHHCCEEEEEECC | 12.90 | - | |
| 176 (in isoform 2) | Phosphorylation | - | 12.90 | - | |
| 177 | Ubiquitination | NPEVEGTLIRVPIPQ CHHHCCEEEEEECCC | 3.28 | 24816145 | |
| 207 | Phosphorylation | NTNKAKDSLRKVRTN CCHHHHHHHHHHHHH | 29.39 | 26091039 | |
| 213 | O-linked_Glycosylation | DSLRKVRTNSMNKLK HHHHHHHHHHHHHHH | 34.33 | 30379171 | |
| 221 | Ubiquitination | NSMNKLKKSKDTVSE HHHHHHHHCCCCCCH | 73.50 | 24816145 | |
| 222 | Phosphorylation | SMNKLKKSKDTVSED HHHHHHHCCCCCCHH | 33.89 | 20068231 | |
| 225 | Phosphorylation | KLKKSKDTVSEDTIR HHHHCCCCCCHHHHH | 29.66 | 20068231 | |
| 227 | Phosphorylation | KKSKDTVSEDTIRLI HHCCCCCCHHHHHHH | 31.67 | 20068231 | |
| 230 | Phosphorylation | KDTVSEDTIRLIEKQ CCCCCHHHHHHHHHH | 12.16 | 20068231 | |
| 236 | Acetylation | DTIRLIEKQISQMAD HHHHHHHHHHHHHCC | 46.03 | 26051181 | |
| 242 | Ubiquitination | EKQISQMADDTVAEL HHHHHHHCCHHHHHH | 12.14 | 24816145 | |
| 245 | Phosphorylation | ISQMADDTVAELDRH HHHHCCHHHHHHHHH | 23.35 | - | |
| 256 | 2-Hydroxyisobutyrylation | LDRHLAVKTKELLG- HHHHHHHHHHHHHC- | 48.55 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RRFM_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RRFM_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RRFM_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| RS19_HUMAN | RPS19 | physical | 22939629 | |
| SARNP_HUMAN | SARNP | physical | 22939629 | |
| SLIRP_HUMAN | SLIRP | physical | 22939629 | |
| SRPRB_HUMAN | SRPRB | physical | 22939629 | |
| ODB2_HUMAN | DBT | physical | 26186194 | |
| MMAB_HUMAN | MMAB | physical | 26186194 | |
| NFS1_HUMAN | NFS1 | physical | 26186194 | |
| LYRM7_HUMAN | LYRM7 | physical | 26186194 | |
| CAF17_HUMAN | IBA57 | physical | 26186194 | |
| ODB2_HUMAN | DBT | physical | 28514442 | |
| NFS1_HUMAN | NFS1 | physical | 28514442 | |
| MMAB_HUMAN | MMAB | physical | 28514442 | |
| CAF17_HUMAN | IBA57 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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