HGF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HGF_HUMAN
• UniProt AC: P14210
• Protein Name: Hepatocyte growth factor
• Gene Name: HGF
• Organism: Homo sapiens (Human).
• Sequence Length: 728
• Protein Description: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization..
• Protein Sequence: MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Pyrrolidone_carboxylic_acid	AIPYAEGQRKRRNTI HCCCCCCHHHHHCCH	38.95	-
32	Pyrrolidone_carboxylic_acid	AIPYAEGQRKRRNTI HCCCCCCHHHHHCCH	38.95	1826837
32	Pyrrolidone_carboxylic_acid	AIPYAEGQRKRRNTI HCCCCCCHHHHHCCH	38.95	1826837
45	Phosphorylation	TIHEFKKSAKTTLIK CHHHHHHHCCCEEEE	35.27	18785766
48	Phosphorylation	EFKKSAKTTLIKIDP HHHHHCCCEEEEECC	26.93	-
294	N-linked_Glycosylation	TCADNTMNDTDVPLE ECCCCCCCCCCCCCC	47.17	UniProtKB CARBOHYD
402	N-linked_Glycosylation	NGKNYMGNLSQTRSG CCCCCCCCCHHCCCC	21.71	UniProtKB CARBOHYD
476	O-linked_Glycosylation	CEGDTTPTIVNLDHP CCCCCCCCEEECCCC	35.15	1482348
522	Phosphorylation	NKHICGGSLIKESWV CCCCCCCCCHHHHHE	16.53	24719451
531	Phosphorylation	IKESWVLTARQCFPS HHHHHEEEEHHHCCC	15.35	24719451
566	N-linked_Glycosylation	EKCKQVLNVSQLVYG HHHHHHEEHHHHHCC	32.32	UniProtKB CARBOHYD
653	N-linked_Glycosylation	HRGKVTLNESEICAG CCCCCCCCHHHCCCC	41.19	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HGF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HGF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HGF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDC2_HUMAN	SDC2	physical	8157651
HGF_HUMAN	HGF	physical	11597998
MET_HUMAN	MET	physical	1655405
MEOX2_HUMAN	MEOX2	physical	25416956
ATL4_HUMAN	ADAMTSL4	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681
FKBP7_HUMAN	FKBP7	physical	26186194
FINC_HUMAN	FN1	physical	25241761
FKBP7_HUMAN	FKBP7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608265: Deafness, autosomal recessive, 39 (DFNB39)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Hepatocyte growth factor is linked by O-glycosylated oligosaccharideon the alpha chain.";
Shimizu N., Hara H., Sogabe T., Sakai H., Ihara I., Inoue H.,Nakamura T., Shimizu S.;
Biochem. Biophys. Res. Commun. 189:1329-1335(1992).
Cited for: GLYCOSYLATION AT THR-476.
PubMed: 1482348