SPSB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPSB4_HUMAN
• UniProt AC: Q96A44
• Protein Name: SPRY domain-containing SOCS box protein 4
• Gene Name: SPSB4
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MGQKLSGSLKSVEVREPALRPAKRELRGAEPGRPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGKNQPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MGQKLSGSLKS ----CCCCCCCCCCE	38.60	32015554
6	Phosphorylation	--MGQKLSGSLKSVE --CCCCCCCCCCEEE	33.11	24719451
8	Phosphorylation	MGQKLSGSLKSVEVR CCCCCCCCCCEEECC	29.28	24719451
10	Ubiquitination	QKLSGSLKSVEVREP CCCCCCCCEEECCCC	54.90	32015554
11	Phosphorylation	KLSGSLKSVEVREPA CCCCCCCEEECCCCH	28.89	24719451
23	Ubiquitination	EPALRPAKRELRGAE CCHHCHHHHHHCCCC	49.43	25015289
74	Phosphorylation	VKDDDRLTFHRHPVA EECCCCEEEECCCCC	20.49	24043423
83	O-linked_Glycosylation	HRHPVAQSTDGIRGK ECCCCCCCCCCCCCC	20.80	30379171
84	Phosphorylation	RHPVAQSTDGIRGKV CCCCCCCCCCCCCCC	26.60	24043423
129	Phosphorylation	APLHSVGYTALVGSD CCCCCCCCEEEECCC	6.15	22468782
258	Phosphorylation	RQRLQDISSLPLPQS HHHHHHHHHCCCCHH	33.83	-
259	Phosphorylation	QRLQDISSLPLPQSL HHHHHHHHCCCCHHH	34.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPSB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPSB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPSB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOS2_HUMAN	NOS2	physical	21199876
NOS2_HUMAN	NOS2	physical	20603330
DDX4_HUMAN	DDX4	physical	20561531
PAWR_HUMAN	PAWR	physical	20561531
ELOC_HUMAN	TCEB1	physical	19159283
CUL5_HUMAN	CUL5	physical	15601820
RBX2_HUMAN	RNF7	physical	15601820
ELOB_HUMAN	TCEB2	physical	15601820
ELOC_HUMAN	TCEB1	physical	15601820

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.