TYSD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYSD1_HUMAN
• UniProt AC: Q2T9J0
• Protein Name: Peroxisomal leader peptide-processing protease
• Gene Name: TYSND1
• Organism: Homo sapiens (Human).
• Sequence Length: 566
• Subcellular Localization: Peroxisome .
• Protein Description: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids..
• Protein Sequence: MRRQWGSAMRAAEQAGCMVSASRAGQPEAGPWSCSGVILSRSPGLVLCHGGIFVPFLRAGSEVLTAAGAVFLPGDSCRDDLRLHVQWAPTAAGPGGGAERGRPGLCTPQCASLEPGPPAPSRGRPLQPRLPAELLLLLSCPAFWAHFARLFGDEAAEQWRFSSAARDDEVSEDEEADQLRALGWFALLGVRLGQEEVEEERGPAMAVSPLGAVPKGAPLLVCGSPFGAFCPDIFLNTLSCGVLSNVAGPLLLTDARCLPGTEGGGVFTARPAGALVALVVAPLCWKAGEWVGFTLLCAAAPLFRAARDALHRLPHSTAALAALLPPEVGVPWGLPLRDSGPLWAAAAVLVECGTVWGSGVAVAPRLVVTCRHVSPREAARVLVRSTTPKSVAIWGRVVFATQETCPYDIAVVSLEEDLDDVPIPVPAEHFHEGEAVSVVGFGVFGQSCGPSVTSGILSAVVQVNGTPVMLQTTCAVHSGSSGGPLFSNHSGNLLGIITSNTRDNNTGATYPHLNFSIPITVLQPALQQYSQTQDLGGLRELDRAAEPVRVVWRLQRPLAEAPRSKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
107	Phosphorylation	RGRPGLCTPQCASLE CCCCCCCCCCCCCCC	22.80	22617229
112	Phosphorylation	LCTPQCASLEPGPPA CCCCCCCCCCCCCCC	40.67	28450419
121	Phosphorylation	EPGPPAPSRGRPLQP CCCCCCCCCCCCCCC	49.85	27251275
171	Phosphorylation	AARDDEVSEDEEADQ CCCCCCCCCCHHHHH	36.96	21712546
389	Ubiquitination	LVRSTTPKSVAIWGR HHHCCCCCEEEEEEE	56.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYSD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYSD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYSD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACOX1_HUMAN	ACOX1	physical	22002062
TY3H_HUMAN	TH	physical	22002062
TYSD1_HUMAN	TYSND1	physical	22002062
HSP7C_HUMAN	HSPA8	physical	28514442
CHIP_HUMAN	STUB1	physical	28514442
ANR40_HUMAN	ANKRD40	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.