dbPTM

TY3H_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TY3H_HUMAN
UniProt AC	P07101
Protein Name	Tyrosine 3-monooxygenase
Gene Name	TH
Organism	Homo sapiens (Human).
Sequence Length	528
Subcellular Localization
Protein Description	Plays an important role in the physiology of adrenergic neurons..
Protein Sequence	MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPTPDATTPQ -----CCCCCCCCHH	32.28	27732954
7	Phosphorylation	-MPTPDATTPQAKGF -CCCCCCCCHHHHHH	46.52	30177828
8	Phosphorylation	MPTPDATTPQAKGFR CCCCCCCCHHHHHHH	18.34	30177828
19	Phosphorylation	KGFRRAVSELDAKQA HHHHHHHHHCCHHHC	31.30	27499020
31 (in isoform 6)	Phosphorylation	-	5.20	27732954
31 (in isoform 3)	Phosphorylation	-	5.20	27732954
35 (in isoform 5)	Phosphorylation	-	36.24	-
35 (in isoform 4)	Phosphorylation	-	36.24	-
36 (in isoform 2)	Phosphorylation	-	9.66	11359875
40 (in isoform 6)	Phosphorylation	-	44.47	11502746
40 (in isoform 3)	Phosphorylation	-	44.47	11502746
40	Phosphorylation	GQGAPGPSLTGSPWP CCCCCCCCCCCCCCC	44.47	20166139
62	Phosphorylation	SYTPTPRSPRFIGRR HCCCCCCCCCCCCCC	22.94	7901013
71	Phosphorylation	RFIGRRQSLIEDARK CCCCCCHHHHHHHHH	29.51	16644734
118	Phosphorylation	AVLNLLFSPRATKPS HHHHHHHCCCCCCHH	17.28	27732954
146	Phosphorylation	AKIHHLETRPAQRPR HHHHCHHCCCCCCCC	48.60	28387310
177	Phosphorylation	GDLAALLSGVRQVSE CCHHHHHHCCCCCCH	35.77	24719451
212	Phosphorylation	DKCHHLVTKFDPDLD HHCCCHHHCCCCCCC	32.14	24719451
230	Phosphorylation	PGFSDQVYRQRRKLI CCCCHHHHHHHHHHH	8.73	-
326	Phosphorylation	RPVAGLLSARDFLAS CCCCHHHHHHHHHHH	26.71	24719451
419	Phosphorylation	QNGEVKAYGAGLLSS CCCEEEEECCCHHHH	11.20	-
427	Nitrated tyrosine	GAGLLSSYGELLHCL CCCHHHHHHHHHHHH	15.96	-
435	Phosphorylation	GELLHCLSEEPEIRA HHHHHHHCCCCCCCC	45.36	12421349
453	Nitrated tyrosine	EAAAVQPYQDQTYQS HHHCCCCCCCCCCCE	13.97	-
458	Nitrated tyrosine	QPYQDQTYQSVYFVS CCCCCCCCCEEEEEE	7.99	-
462	Nitrated tyrosine	DQTYQSVYFVSESFS CCCCCEEEEEECCCC	11.96	-
502	Phosphorylation	LAIDVLDSPQAVRRS EEEECCCCHHHHHHH	18.10	27732954
509	Phosphorylation	SPQAVRRSLEGVQDE CHHHHHHHHHHHHHH	21.87	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
19	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
19	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
19	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
19	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
19	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
19	S	Phosphorylation	Kinase	KCC2A	Q9UQM7	PhosphoELM
19	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
19	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
19	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
19	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
19	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
19	S	Phosphorylation	Kinase	MAPK2	P49137	PhosphoELM
19	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	PSP
19	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
31	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
31	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
31	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
35	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
35	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
40	S	Phosphorylation	Kinase	PKACA	P17612	PSP
40	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
40	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	PSP
40	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
40	S	Phosphorylation	Kinase	MAPKAPK2	P49137	GPS
40	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
40	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
40	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
40	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
40	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
40	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
44	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
44	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
44	S	Phosphorylation	Kinase	PKACA	P17612	PSP
44	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
44	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
44	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
58	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
58	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
62	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
62	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
67	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
67	S	Phosphorylation	Kinase	PKACA	P17612	PSP
67	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
67	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
67	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
71	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
71	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
71	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
71	S	Phosphorylation	Kinase	PKA	-	Uniprot
71	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
71	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
71	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
71	S	Phosphorylation	Kinase	KCC2A	Q9UQM7	PhosphoELM
71	S	Phosphorylation	Kinase	PKACA	P17612	PSP
71	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
404	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	PSP
404	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TY3H_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TY3H_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM3B_HUMAN	KDM3B	physical	28514442
NFIC_HUMAN	NFIC	physical	28514442
RELL1_HUMAN	RELL1	physical	28514442
DJC12_HUMAN	DNAJC12	physical	28514442
ZBT34_HUMAN	ZBTB34	physical	28514442
MTFR2_HUMAN	MTFR2	physical	28514442
M3K7_HUMAN	MAP3K7	physical	28514442
TAOK2_HUMAN	TAOK2	physical	28514442
TAB1_HUMAN	TAB1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
605407	Segawa syndrome autosomal recessive (ARSEGS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00120	L-Phenylalanine
DB00135	L-Tyrosine
DB00765	Metyrosine
DB00360	Tetrahydrobiopterin

Regulatory Network of TY3H_HUMAN

Related Literatures of Post-Translational Modification