RELL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RELL1_HUMAN
• UniProt AC: Q8IUW5
• Protein Name: RELT-like protein 1
• Gene Name: RELL1
• Organism: Homo sapiens (Human).
• Sequence Length: 271
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Sequence: MAPRALPGSAVLAAAVFVGGAVSSPLVAPDNGSSRTLHSRTETTPSPSNDTGNGHPEYIAYALVPVFFIMGLFGVLICHLLKKKGYRCTTEAEQDIEEEKVEKIELNDSVNENSDTVGQIVHYIMKNEANADVLKAMVADNSLYDPESPVTPSTPGSPPVSPGPLSPGGTPGKHVCGHHLHTVGGVVERDVCHRCRHKRWHFIKPTNKSRESRPRRQGEVTVLSVGRFRVTKVEHKSNQKERRSLMSVSGAETVNGEVPATPVKRERSGTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	FVGGAVSSPLVAPDN ECCCHHCCCEECCCC	18.69	28387310
31	N-linked_Glycosylation	SPLVAPDNGSSRTLH CCEECCCCCCCCEEE	51.71	UniProtKB CARBOHYD
49	N-linked_Glycosylation	ETTPSPSNDTGNGHP CCCCCCCCCCCCCCH	55.00	UniProtKB CARBOHYD
88	S-palmitoylation	LKKKGYRCTTEAEQD HHHCCCCCCCHHHHC	4.09	21044946
103	Ubiquitination	IEEEKVEKIELNDSV HHHHHCEEEECCCCC	44.46	29967540
109	Phosphorylation	EKIELNDSVNENSDT EEEECCCCCCCCCCC	26.26	30278072
114	Phosphorylation	NDSVNENSDTVGQIV CCCCCCCCCCHHHHH	28.60	25159151
116	Phosphorylation	SVNENSDTVGQIVHY CCCCCCCCHHHHHHH	26.76	29978859
123	Phosphorylation	TVGQIVHYIMKNEAN CHHHHHHHHHHCCCC	7.57	28857561
126	Ubiquitination	QIVHYIMKNEANADV HHHHHHHHCCCCHHH	41.92	29967540
135	Ubiquitination	EANADVLKAMVADNS CCCHHHHHHHHCCCC	33.99	29967540
137	Ubiquitination	NADVLKAMVADNSLY CHHHHHHHHCCCCCC	2.14	22817900
142	Phosphorylation	KAMVADNSLYDPESP HHHHCCCCCCCCCCC	28.93	20068231
144	Phosphorylation	MVADNSLYDPESPVT HHCCCCCCCCCCCCC	29.31	20068231
148	Phosphorylation	NSLYDPESPVTPSTP CCCCCCCCCCCCCCC	30.02	25850435
151	Phosphorylation	YDPESPVTPSTPGSP CCCCCCCCCCCCCCC	18.20	26657352
153	Phosphorylation	PESPVTPSTPGSPPV CCCCCCCCCCCCCCC	37.56	25159151
154	Phosphorylation	ESPVTPSTPGSPPVS CCCCCCCCCCCCCCC	32.64	25159151
157	Phosphorylation	VTPSTPGSPPVSPGP CCCCCCCCCCCCCCC	27.51	28355574
161	Phosphorylation	TPGSPPVSPGPLSPG CCCCCCCCCCCCCCC	29.88	29255136
166	Phosphorylation	PVSPGPLSPGGTPGK CCCCCCCCCCCCCCC	25.32	29255136
170	Phosphorylation	GPLSPGGTPGKHVCG CCCCCCCCCCCCCCC	34.48	29255136
182	Phosphorylation	VCGHHLHTVGGVVER CCCCCEEECCCEECH	27.49	29255136
204	Ubiquitination	HKRWHFIKPTNKSRE CCCCEEECCCCCCCC	44.86	29967540
224	Phosphorylation	QGEVTVLSVGRFRVT CCCEEEEEEEEEEEE	20.42	26699800
240	Trimethylation	VEHKSNQKERRSLMS EEECCCHHHHHHHCC	58.39	-
240	Methylation	VEHKSNQKERRSLMS EEECCCHHHHHHHCC	58.39	23644510
244	Phosphorylation	SNQKERRSLMSVSGA CCHHHHHHHCCCCCC	34.35	30266825
247	Phosphorylation	KERRSLMSVSGAETV HHHHHHCCCCCCCCC	20.58	30266825
249	Phosphorylation	RRSLMSVSGAETVNG HHHHCCCCCCCCCCC	25.61	30266825
253	Phosphorylation	MSVSGAETVNGEVPA CCCCCCCCCCCCCCC	20.81	30266825
261	Phosphorylation	VNGEVPATPVKRERS CCCCCCCCCCCCCCC	23.65	30266825
264	Ubiquitination	EVPATPVKRERSGTE CCCCCCCCCCCCCCC	50.15	22817900
268	Phosphorylation	TPVKRERSGTE---- CCCCCCCCCCC----	45.36	20736484
270	Phosphorylation	VKRERSGTE------ CCCCCCCCC------	39.50	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RELL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RELL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RELL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OXSR1_HUMAN	OXSR1	physical	28514442
STK39_HUMAN	STK39	physical	28514442
SNX18_HUMAN	SNX18	physical	28514442
TCAF2_HUMAN	FAM115C	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
MGAT1_HUMAN	MGAT1	physical	28514442
KDSR_HUMAN	KDSR	physical	28514442
CERS2_HUMAN	CERS2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244 AND SER-247, ANDMASS SPECTROMETRY.
PubMed: 18669648