MTFR2_HUMAN - dbPTM
MTFR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTFR2_HUMAN
UniProt AC Q6P444
Protein Name Mitochondrial fission regulator 2
Gene Name MTFR2
Organism Homo sapiens (Human).
Sequence Length 385
Subcellular Localization Mitochondrion. Associated with membranes..
Protein Description May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity)..
Protein Sequence MSLILNILREMLEYFGVPVEQVLLIWENKDYGSTRSIVRIIGKMLPLEPCRRPNFELIPLLNSVDSDNCGSMVPSFADILYVANDEEASYLRFRNSIWKNEEEKVEIFHPLRLVRDPLSPAVRQKETVKNDLPVNEAAIRKIAALENELTFLRSQIAAIVEMQELKNSTNSSSFGLSDERISLGQLSSSRAAHLSVDPDQLPGSVLSPPPPPPLPPQFSSLQPPCFPPVQPGSNNICDSDNPATEMSKQNPAANKTNYSHHSKSQRNKDIPNMLDVLKDMNKVKLRAIERSPGGRPIHKRKRQNSHWDPVSLISHALKQKFAFQEDDSFEKENRSWESSPFSSPETSRFGHHISQSEGQRTKEEMVNTKAVDQGISNTSLLNSRI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSLILNILR
------CCHHHHHHH		25944712
43UbiquitinationSIVRIIGKMLPLEPC
HHHHHHHHHCCCCCC		-
61UbiquitinationNFELIPLLNSVDSDN
CCEEEECCCCCCCCC		29967540
82UbiquitinationSFADILYVANDEEAS
CHHHEEEECCCHHHH		22817900
86 (in isoform 2)Ubiquitination-21906983
86UbiquitinationILYVANDEEASYLRF
EEEECCCHHHHHHHH		22817900
98 (in isoform 2)Ubiquitination-21906983
98UbiquitinationLRFRNSIWKNEEEKV
HHHHHCCCCCHHHHH		22817900
99UbiquitinationRFRNSIWKNEEEKVE
HHHHCCCCCHHHHHE		-
104UbiquitinationIWKNEEEKVEIFHPL
CCCCHHHHHEEECHH		29967540
119PhosphorylationRLVRDPLSPAVRQKE
HHHCCCCCHHHCCHH		29255136
123 (in isoform 2)Ubiquitination-21906983
123UbiquitinationDPLSPAVRQKETVKN
CCCCHHHCCHHHHCC		22817900
125UbiquitinationLSPAVRQKETVKNDL
CCHHHCCHHHHCCCC		22817900
129 (in isoform 1)Ubiquitination-21906983
129UbiquitinationVRQKETVKNDLPVNE
HCCHHHHCCCCCCCH		22817900
141UbiquitinationVNEAAIRKIAALENE
CCHHHHHHHHHHHHH		21906983
141 (in isoform 1)Ubiquitination-21906983
154PhosphorylationNELTFLRSQIAAIVE
HHHHHHHHHHHHHHH		20068231
166 (in isoform 1)Ubiquitination-21906983
166UbiquitinationIVEMQELKNSTNSSS
HHHHHHHHCCCCCCC		22817900
172PhosphorylationLKNSTNSSSFGLSDE
HHCCCCCCCCCCCCC		25627689
173PhosphorylationKNSTNSSSFGLSDER
HCCCCCCCCCCCCCC		25159151
182PhosphorylationGLSDERISLGQLSSS
CCCCCCEEHHHCCCC		28555341
187PhosphorylationRISLGQLSSSRAAHL
CEEHHHCCCCCCCCC		20068231
188PhosphorylationISLGQLSSSRAAHLS
EEHHHCCCCCCCCCC		20068231
189PhosphorylationSLGQLSSSRAAHLSV
EHHHCCCCCCCCCCC		20068231
220UbiquitinationPLPPQFSSLQPPCFP
CCCCCCCCCCCCCCC		23503661
225UbiquitinationFSSLQPPCFPPVQPG
CCCCCCCCCCCCCCC		23503661
235UbiquitinationPVQPGSNNICDSDNP
CCCCCCCCCCCCCCC		23503661
239UbiquitinationGSNNICDSDNPATEM
CCCCCCCCCCCCHHH		23503661
241UbiquitinationNNICDSDNPATEMSK
CCCCCCCCCCHHHHH		23503661
263UbiquitinationTNYSHHSKSQRNKDI
CCCCCCCHHHCCCCC		23503661
268UbiquitinationHSKSQRNKDIPNMLD
CCHHHCCCCCCHHHH		23503661
278UbiquitinationPNMLDVLKDMNKVKL
CHHHHHHHHHCCCHH		23503661
278AcetylationPNMLDVLKDMNKVKL
CHHHHHHHHHCCCHH		11792131
282UbiquitinationDVLKDMNKVKLRAIE
HHHHHHCCCHHHHHH		23503661
284UbiquitinationLKDMNKVKLRAIERS
HHHHCCCHHHHHHCC		23503661
288UbiquitinationNKVKLRAIERSPGGR
CCCHHHHHHCCCCCC		29967540
291PhosphorylationKLRAIERSPGGRPIH
HHHHHHCCCCCCCCC		27174698
305PhosphorylationHKRKRQNSHWDPVSL
CCCCCCCCCCCHHHH		30576142
311PhosphorylationNSHWDPVSLISHALK
CCCCCHHHHHHHHHH		20873877
314PhosphorylationWDPVSLISHALKQKF
CCHHHHHHHHHHHHH		20873877
320UbiquitinationISHALKQKFAFQEDD
HHHHHHHHHCCCCCC		-
328PhosphorylationFAFQEDDSFEKENRS
HCCCCCCCHHHHCCC		30266825
331UbiquitinationQEDDSFEKENRSWES
CCCCCHHHHCCCCCC		29967540
335PhosphorylationSFEKENRSWESSPFS
CHHHHCCCCCCCCCC		23186163
339PhosphorylationENRSWESSPFSSPET
HCCCCCCCCCCCCCH		30576142
342PhosphorylationSWESSPFSSPETSRF
CCCCCCCCCCCHHHC		25159151
343PhosphorylationWESSPFSSPETSRFG
CCCCCCCCCCHHHCC		25627689
346PhosphorylationSPFSSPETSRFGHHI
CCCCCCCHHHCCCCC		30576142
354PhosphorylationSRFGHHISQSEGQRT
HHCCCCCCHHCCCCC		25159151
356PhosphorylationFGHHISQSEGQRTKE
CCCCCCHHCCCCCHH		30576142
376PhosphorylationKAVDQGISNTSLLNS
HHHHCCCCCHHHHHC		28450419
378PhosphorylationVDQGISNTSLLNSRI
HHCCCCCHHHHHCCC		28450419
379PhosphorylationDQGISNTSLLNSRI-
HCCCCCHHHHHCCC-		28450419
383PhosphorylationSNTSLLNSRI-----
CCHHHHHCCC-----		29978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTFR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTFR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTFR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KLDC2_HUMANKLHDC2physical
26186194
SIR1_HUMANSIRT1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTFR2_HUMAN

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Related Literatures of Post-Translational Modification

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